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Proteome Profiler Human Phospho-RTK Array Kit
R&D Systems, Inc. a Bio-Techne Brand
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Detection of Human Receptor Tyrosine Kinase Phosphorylation in KATO-III Cell Line. KATO-III human gastric carcinoma cells were either untreated or treated with 100 ng/mL rhFGF acidic and 1 μg/mL heparin for 15 minutes. Cells for rhFGF acidic/Heparin treatment either received pre-treatment with the reversible FGF R and VEGF R inhibitor PD 173074 (Tocris, Catalog # 3044), or with the FGF R-specific tyrosine kinase inhibitor SU 5402 (Tocris, Catalog # 3300), or no pre-treatment. |
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The Human Phospho-RTK Array is specific for ErbB2, ErbB3, and ErbB4 as shown by receptor competition. MDA-MB-453 human breast cancer cells were treated with 100 ng/mL of rhNRG1-beta1/HRG1-beta1 (R&D Systems, Catalog # 396-HB) for 5 minutes. 5 µg of rhErbB2 (R&D Systems, Catalog # 1129-ER), rhErbB3 (R&D Systems, Catalog # 348-RB), or rhErbB4 (R&D Systems, Catalog # 1131-ER) extracellular domains were added to 50 µg of lysate and analyzed using the Human Phospho-RTK Array. Competition of a particular ErbB receptor was observed only with the corresponding recombinant soluble receptor. |
Citations for Proteome Profiler Human Phospho-RTK Array Kit (251)
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Citations are publications that use Bio-Techne products. Selected citations for Proteome Profiler Human Phospho-RTK Array Kit include:
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Species: Human
Sample Types: Cell Culture Supernates
ZS Lin et al. (2023), EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression Elife, 12(0).
PMID: 36622753 -
Species: Human
Sample Types: Cell Lysates
C Vannas et al. (2022), Different HSP90 Inhibitors Exert Divergent Effect on Myxoid Liposarcoma In Vitro and In Vivo Biomedicines, 10(3).
PMID: 35327426 -
Species: Human
Sample Types: Cell Lysates
J Zhi et al. (2022), Targeting SHP2 sensitizes differentiated thyroid carcinoma to the MEK inhibitor American journal of cancer research, 12(1):247-264.
PMID: 35141016 -
Species: Human
Sample Types: Cell Lysates
L Scherschin et al. (2022), Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma International Journal of Molecular Sciences, 23(2).
PMID: 35055167 -
Species: Human
Sample Types: Whole Cells
T Ueda et al. (2022), Stem Cells From Human Exfoliated Deciduous Teeth-Conditioned Medium (SHED-CM) is a Promising Treatment for Amyotrophic Lateral Sclerosis Frontiers in Pharmacology, 13(0):805379.
PMID: 35185565 -
Species: Human
Sample Types: Cell Culture Supernates
S Song et al. (2022), EGFR/MET promotes hepatocellular carcinoma metastasis by stabilizing tumor cells and resisting to RTKs inhibitors in circulating tumor microemboli Cell Death Disease, 2022;13(4):351.
PMID: 35428350 -
Species: Human
Sample Types: Cell Lysates
AJ Weickhardt et al. (2022), Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer BMC Cancer, 22(1):478.
PMID: 35501832 -
Species: Human
Sample Types: Cell Lysates
C Gaiteiro et al. (2022), Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion Theranostics, 12(7):3150-3177.
PMID: 35547758 -
Species: Human
Sample Types: Cell Lysates
MB Ryan et al. (2022), KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy Cell Reports, 39(12):110993.
PMID: 35732135 -
Species: Human
Sample Types: Cell Lysates
M Krchniakov et al. (2022), Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells Frontiers in Pharmacology, 13(0):976955.
PMID: 36160437 -
C Marques et al. (2022), Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates Heparan Sulfate biosynthesis and shapes gastric cancer cell motility and invasion The Journal of Biological Chemistry, 0(0):102546.
PMID: 36181793 -
Species: Human
Sample Types: Cell Culture Supernates
YF Wang et al. (2022), Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer Cell Death Disease, 2022;13(8):748.
PMID: 36038549 -
Species: Human
Sample Types: Cell Lysates
Y Kobayashi et al. (2022), Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors Nature Communications, 13(1):5614.
PMID: 36153311 -
Species: Human
Sample Types: Cell Lysates
SM Dieter et al. (2022), Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors Oncogene, 0(0).
PMID: 35798875 -
Species: Human
Sample Types: Cell Lysates
SH Park et al. (2022), Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages Experimental Molecular Medicine, 2022;0(0).
PMID: 36352257 -
Species: Human
Sample Types: Cell Culture Supernates
P Zhang et al. (2021), Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration Bioactive materials, 6(10):3097-3108.
PMID: 33778191 -
Species: Human
Sample Types: Cell Lysates
J Lee et al. (2021), Identification of Phospho-Tyrosine Targets as a Strategy for the Treatment of Esophageal Adenocarcinoma Cells OncoTargets and Therapy, 14(0):3813-3820.
PMID: 34188489 -
Species: Human
Sample Types: Cell Lysates
A Morishita et al. (2021), Galectin?9 suppresses the tumor growth of colon cancer in�vitro and in�vivo Oncology reports, 45(6).
PMID: 33907832 -
Species: Human
Sample Types: Cell Lysates
N Singh et al. (2021), Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells Nature Medicine, 0(0).
PMID: 33888899 -
Species: Human
Sample Types: Cell Lysates
M Mahdal et al. (2021), New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRbeta Signaling Cancers, 13(14).
PMID: 34298757 -
Species: Human
Sample Types: Cell Lysates
SJ Lee et al. (2021), Identification of Nucleolin as a Novel AEG-1-Interacting Protein in Breast Cancer via Interactome Profiling Cancers, 13(11).
PMID: 34200450 -
Species: Human
Sample Types: Cell Lysates
P Ebner-Peki et al. (2021), Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration Theranostics, 11(17):8430-8447.
PMID: 34373751 -
Species: Human
Sample Types: Cell Lysates
HH Lee et al. (2021), Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation Nature Communications, 12(1):2788.
PMID: 33986289 -
Species: Human
Sample Types: Cell Lysates
SJ Oh et al. (2021), Interaction between SCP3 and JAB1 Confers Cancer Therapeutic Resistance and Stem-like Properties through EGF Expression International Journal of Molecular Sciences, 22(16).
PMID: 34445562 -
Species: Human
Sample Types: Cell Lysates
J Tsui et al. (2021), Identification of a Resistance Mechanism to IGF-IR Targeting in Human Triple Negative MDA-MB-231 Breast Cancer Cells Biomolecules, 11(4).
PMID: 33916323 -
Species: Human
Sample Types: Cell Culture Supernates
YP Wang et al. (2021), NOTCH1 signaling promotes protein stability of HER3 through the AKT pathway in squamous cell carcinoma of head and neck Oncogenesis, 10(8):59.
PMID: 34465724 -
Species: Human
Sample Types: Cell Lysates
PN Chen et al. (2021), Oral submucous fibrosis stimulates invasion and epithelial-mesenchymal transition in oral squamous cell carcinoma by activating MMP-2 and IGF-IR Journal of Cellular and Molecular Medicine, 0(0).
PMID: 34528373 -
Species: Canine
Sample Types: Protein Lysates
DI Korec et al. (2021), Characterization of receptor tyrosine kinase activation and biological activity of toceranib phosphate in canine urothelial carcinoma cell lines Bmc Veterinary Research, 17(1):320.
PMID: 34600548 -
Species: Human
Sample Types: Cell Culture Supernates
C Lailler et al. (2021), DNA damage response- and JAK-dependent regulation of PD-L1 expression in head and neck squamous cell carcinoma (HNSCC) cells exposed to 5-fluorouracil (5-FU) Translational Oncology, 14(8):101110.
PMID: 33951601 -
Species: Human
Sample Types: Cell Lysates
JD Choi et al. (2021), ISL1 promotes enzalutamide resistance in castration-resistant prostate cancer (CRPC) through epithelial to mesenchymal transition (EMT) Scientific Reports, 11(1):21984.
PMID: 34753990 -
Species: Human
Sample Types: Cell Lysates
H Patel et al. (2021), IGF1R/IR Mediates Resistance to BRAF and MEK Inhibitors in BRAF-Mutant Melanoma Cancers, 13(22).
PMID: 34831014 -
Species: Human
Sample Types: Cell Lysates
TA Mannsåker et al. (2021), Cabozantinib Is Effective in Melanoma Brain Metastasis Cell Lines and Affects Key Signaling Pathways International Journal of Molecular Sciences, 22(22).
PMID: 34830178 -
Species: Human
Sample Types: Whole Cells
RS Smith et al. (2021), Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability Disease Models Mechanisms, 2021;0(0).
PMID: 34841430 -
Species: Human
Sample Types: Whole Cells
K Nishii et al. (2021), Triple therapy with osimertinib, bevacizumab and cetuximab in EGFR-mutant lung cancer with HIF-1alpha/TGF-alpha expression Oncology Letters, 22(3):639.
PMID: 34386061 -
Species: Human
Sample Types: Cell Lysates
T Sato et al. (2021), Three newly established immortalized mesothelial cell lines exhibit morphological phenotypes corresponding to malignant mesothelioma epithelioid, intermediate, and sarcomatoid types, respectively Cancer Cell International, 21(1):546.
PMID: 34663305 -
Species: Human
Sample Types: Cell Lysates
S Hafner et al. (2021), The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells Frontiers in Pharmacology, 12(0):611657.
PMID: 34025398 -
Species: Human
Sample Types: Cell Lysates
O Billing et al. (2021), LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance Oncogene, 0(0).
PMID: 33947959 -
Species: Human
Sample Types: Cell Lysates
AC Harttrampf et al. (2021), Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation BMC Cancer, 21(1):833.
PMID: 34281526 -
Species: Human
Sample Types: Cell Lysates
T Manabe et al. (2020), IGF2 autocrine-mediated IGF1R activation is a clinically relevant mechanism of osimertinib resistance in lung cancer Mol. Cancer Res., 0(0).
PMID: 31941753 -
Species: Human
Sample Types: Cell Lysates
J Kim et al. (2020), STAT3 Relays a Differential Response to Melanoma-Associated NRAS Mutations Cancers (Basel), 12(1).
PMID: 31906480 -
Species: Mouse
Sample Types: Protein Lysates
J Skoda et al. (2020), Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells Cancers (Basel), 12(1).
PMID: 31941033 -
Species: Human
Sample Types: Whole Cells
J Lee et al. (2020), Differential Dependency of Human Pancreatic Cancer Cells on Targeting PTEN via PLK 1 Expression Cancers (Basel), 12(2).
PMID: 31979216 -
Species: Human
Sample Types: Cell Culture Lysates
CL Cheng et al. (2020), CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway Cells, 9(7).
PMID: 32708730 -
Species: Human
Sample Types: Tissue Homogenates
N Yanagitani et al. (2020), Drug resistance mechanisms in Japanese anaplastic lymphoma kinase-positive non-small cell lung cancer and the clinical responses based on the resistant mechanisms Cancer Sci., 111(3):932-939.
PMID: 31961053 -
Species: Human
Sample Types: Tissue Homogenates
WC Liao et al. (2020), Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability Oncogenesis, 9(2):9.
PMID: 32019907 -
Species: Human
Sample Types: Cell Culture Lysates
PC Lee et al. (2020), C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer Oncogene, 0(0).
PMID: 32005975 -
Species: Human
Sample Types: Whole Cells
ES Lee et al. (2020), Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042 Mar Drugs, 18(9).
PMID: 32927886 -
Species: Human
Sample Types: Cell Lysates
P Hollósi et al. (2020), Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1 Biomolecules, 10(10).
PMID: 32977498 -
Species: Human
Sample Types: Cell Lysates
S Roy et al. (2020), MDM2 Antagonists Induce a Paradoxical Activation of Erk1/2 through a P53-Dependent Mechanism in Dedifferentiated Liposarcomas: Implications for Combinatorial Strategies Cancers (Basel), 12(8).
PMID: 32806555 -
Species: Human
Sample Types: Serum
B Zhou et al. (2020), Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling Nat Microbiol, 0(0).
PMID: 33077977 -
Species: Human
Sample Types: Cell Lysates
Z Areeb et al. (2020), Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma Sci Rep, 10(1):17768.
PMID: 33082482 -
Species: Human
Sample Types: Cell Lysates
M Fuentes-Ba et al. (2020), Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines Cancers, 12(12).
PMID: 33322337 -
Species: Human
Sample Types: Cell Lysates
S Pietrobono et al. (2020), ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL Nat Commun, 11(1):5865.
PMID: 33203881 -
Species: Human
Sample Types: Cell Lysates
B Royer-Poko et al. (2020), Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 Mutations Cancers, 13(1).
PMID: 33379206 -
Species: Human
Sample Types: Cell Lysates
YH Chen et al. (2020), EPHA2 feedback activation limits the response to PDEdelta inhibition in KRAS-dependent cancer cells Acta Pharmacol. Sin., 41(2):270-277.
PMID: 31316177 -
Species: Human
Sample Types: Cell Lysates
L Hüser et al. (2020), HER3-Receptor-Mediated STAT3 Activation Plays a Central Role in Adaptive Resistance toward Vemurafenib in Melanoma Cancers, 12(12).
PMID: 33327495 -
Species: Human
Sample Types: Cell Lysates
S Roy et al. (2020), MDM2 Antagonists Induce a Paradoxical Activation of Erk1/2 through a P53-Dependent Mechanism in Dedifferentiated Liposarcomas: Implications for Combinatorial Strategies Cancers (Basel), 12(8).
PMID: 32806555 -
Species: Human
Sample Types: Cell Lysates
S Kim et al. (2020), LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells Autophagy, 0(0):1-20.
PMID: 32762616 -
Species: Human
Sample Types: Cell Lysates
LM van der Wa et al. (2019), Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures Sci Rep, 9(1):819.
PMID: 30692572 -
Species: Human
Sample Types: Cell Lysates
L He et al. (2019), Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis J. Exp. Clin. Cancer Res., 38(1):84.
PMID: 30777099 -
Species: Human
Sample Types: Cell Lysates
K Fukuda et al. (2019), Epithelial-to-mesenchymal transition is a mechanism of ALK inhibitor resistance in lung cancer independent of ALK mutation status Cancer Res., 0(0).
PMID: 30737231 -
Species: Human
Sample Types: Cell Lysates
S Rao et al. (2019), A multi-targeted probe-based strategy to identify signaling vulnerabilities in cancers J. Biol. Chem., 0(0).
PMID: 30858179 -
Species: Human
Sample Types: Cell Lysates
R Graves-Dea et al. (2019), Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer Oncotarget, 10(13):1320-1333.
PMID: 30863492 -
Species: Human
Sample Types: Cell Lysates
A Linkous et al. (2019), Modeling Patient-Derived Glioblastoma with Cerebral Organoids Cell Rep, 26(12):3203-3211.e5.
PMID: 30893594 -
Species: Human
Sample Types: Cell Lysates
TA Ahmed et al. (2019), SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors Cell Rep, 26(1):65-78.e5.
PMID: 30605687 -
Species: Human
Sample Types: Cell Lysates
AM Kurimchak et al. (2019), Intrinsic Resistance to MEK Inhibition Through BET Protein Mediated Kinome Reprogramming in NF1-deficient Ovarian Cancer Mol. Cancer Res., 0(0).
PMID: 31043489 -
Species: Human
Sample Types: Cell Culture Supernates
Z Xiao et al. (2019), Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach Oncotarget, 10(26):2546-2560.
PMID: 31069016 -
Species: Human
Sample Types: Cell Lysates
K Njah et al. (2019), A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis Cell Rep, 28(4):949-965.e7.
PMID: 31340156 -
Species: Human
Sample Types: Whole Cells
T Matsui et al. (2019), Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo Int J Mol Sci, 20(13).
PMID: 31261874 -
Species: Human
Sample Types: Cell Lysates
N Lee et al. (2019), 2-Deoxy-d-Glucose-Induced Metabolic Alteration in Human Oral Squamous SCC15 Cells: Involvement of N-Glycosylation of Axl and Met Metabolites, 9(9).
PMID: 31533338 -
Species: Human
Sample Types: Cell Lysates
R Sulahian et al. (2019), Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers Cell Rep, 29(1):118-134.e8.
PMID: 31577942 -
Species: Equine
Sample Types: Tissue Homogenates
MA de Laat et al. (2019), An investigation of the equine epidermal growth factor system during hyperinsulinemic laminitis PLoS ONE, 14(12):e0225843.
PMID: 31805097 -
Species: Human
Sample Types: Cell Lysates
MT Kuo et al. (2019), Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors Transl Oncol, 13(2):355-364.
PMID: 31887630 -
Species: Human
Sample Types: Whole Cells
SP MacFarland et al. (2019), Mechanisms of entrectinib resistance in a neuroblastoma xenograft model Mol. Cancer Ther., 0(0).
PMID: 31871269 -
Species: Human
Sample Types: Protein
T Sato et al. (2019), Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma Cancer Res., 79(24):6084-6100.
PMID: 31551362 -
Species: Human
Sample Types: Cell Lysates
Q Zhang et al. (2019), Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas BMC Cancer, 19(1):1044.
PMID: 31690270 -
Species: Human
Sample Types: Cell Culture Supernates
S Nakai et al. (2019), Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra-SRS, with autocrine IGF-1R activation and metastatic potential to the lungs Sci Rep, 9(1):15812.
PMID: 31676869 -
Species: Human
Sample Types: Cell Lysates
F Meng et al. (2019), EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming Nat Commun, 10(1):5033.
PMID: 31695034 -
Species: Human
Sample Types: Cell Culture Supernates
Z Horváth et al. (2019), Tumor-specific inhibitory action of decorin on different hepatoma cell lines Cell. Signal., 62(0):109354.
PMID: 31271881 -
Species: Human
Sample Types: Cell Lysates
SH Park et al. (2019), Sonic hedgehog pathway activation is associated with cetuximab resistance and EPHB3 receptor induction in colorectal cancer Theranostics, 9(8):2235-2251.
PMID: 31149041 -
Species: Human
Sample Types: Cell Lysates
SA Greenall et al. (2018), Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3 Transl Oncol, 11(4):971-978.
PMID: 29933129 -
Species: Human
Sample Types: Cell Lysates
F Mao et al. (2018), Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma Oncogenesis, 7(2):13.
PMID: 29391393 -
Species: Human
Sample Types: Tissue Homogenates
B Haas et al. (2018), Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs Cancer Cell Int., 18(0):69.
PMID: 29755294 -
Species: Human
Sample Types: Cell Lysates
K Ninomiya et al. (2018), MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib Sci Rep, 8(1):1955.
PMID: 29386539 -
Species: Human
Sample Types: Cell Lysates
B Leonard et al. (2018), BET inhibition overcomes receptor tyrosine kinase-mediated cetuximab resistance in HNSCC Cancer Res., 0(0).
PMID: 29792310 -
Species: Human
Sample Types: Cell Lysates
R Herr et al. (2018), BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines Oncogene, 0(0).
PMID: 29326440 -
Species: Human
Sample Types: Cell Lysates
H Kotani et al. (2018), Distinct dependencies on receptor tyrosine kinases in the regulation of MAPK signaling between BRAF V600E and non-V600E mutant lung cancers Oncogene, 0(0).
PMID: 29348459 -
Species: Human
Sample Types: Cell Lysates
SN Jung et al. (2018), LAMB3 mediates metastatic tumor behavior in papillary thyroid cancer by regulating c-MET/Akt signals Sci Rep, 8(1):2718.
PMID: 29426928 -
Species: Human
Sample Types: Whole Cells
AH Daneshmane et al. (2018), A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib PLoS ONE, 13(6):e0198038.
PMID: 29856777 -
Species: Human
Sample Types: Cell Lysates
AM Donson et al. (2018), Identification of FDA-approved oncology drugs with selective potency in high-risk childhood ependymoma Mol. Cancer Ther., 0(0).
PMID: 29925527 -
Species: Human
Sample Types: Cell Lysates
Z Fang et al. (2018), Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway Cell. Physiol. Biochem., 47(5):1751-1768.
PMID: 29953970 -
Species: Human
Sample Types: Cell Lysates
PD Fan et al. (2018), YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics Proc. Natl. Acad. Sci. U.S.A., 115(26):E6030-E6038.
PMID: 29875142 -
Species: Human
Sample Types: Cell Lysates
PP Patwardhan et al. (2018), Preclinical Evaluation of Nintedanib, a Triple Angiokinase Inhibitor, in Soft-Tissue Sarcoma: Potential Therapeutic implication for Synovial Sarcoma Mol. Cancer Ther., 0(0).
PMID: 30166401 -
Species: Human
Sample Types: Cell Lysates
S Sun et al. (2018), HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation Cell Death Dis, 9(9):929.
PMID: 30206202 -
Species: Human
Sample Types: Cell Lysates
S Boichuk et al. (2018), Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo Molecules, 23(10).
PMID: 30326595 -
Species: Human
Sample Types: Tissue Homogenates
M Sramek et al. (2018), Effects of Sunitinib and Other Kinase Inhibitors on Cells Harboring a PDGFRB Mutation Associated with Infantile Myofibromatosis Int J Mol Sci, 19(9).
PMID: 30200486 -
Species: Human
Sample Types: Cell Lysates
E Yángüez et al. (2018), Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target Nat Commun, 9(1):3679.
PMID: 30206219 -
Species: Human
Sample Types: Cell Lysates
AR Virzì et al. (2018), Reviving oncogenic addiction to MET bypassed by BRAF (G469A) mutation Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 30224486 -
Species: Porcine
Sample Types: Tissue Homogenates
J Heliste et al. (2018), Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target BMC Cardiovasc Disord, 18(1):196.
PMID: 30342492 -
Species: Human
U Painuly et al. (2018), Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma Oncotarget, 9(77):34582-34594.
PMID: 30349651 -
Species: Human
Sample Types: Cell Culture Supernates
ST Chen et al. (2018), Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway Oncogene, 0(0).
PMID: 29993037 -
Species: Human
Sample Types: Cell Culture Supernates
SH Choi et al. (2018), Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization Nat Commun, 9(1):5108.
PMID: 30504836 -
Species: Human
Sample Types: Cell Lysates
WJ Jang et al. (2018), Anticancer activity of paroxetine in human colon cancer cells: Involvement of MET and ERBB3 J. Cell. Mol. Med., 0(0).
PMID: 30421568 -
Species: Human
Sample Types: Cell Lysates
STK Sin et al. (2018), TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling Gynecol. Oncol., 0(0).
PMID: 30429055 -
Species: Human
Sample Types: Cell Lysates
X Wang et al. (2018), The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors Mol. Cancer Ther., 0(0).
PMID: 30523050 -
Species: Human
Sample Types: Cell Lysates
C Li et al. (2017), Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer Proc. Natl. Acad. Sci. U.S.A, 0(0).
PMID: 28320945 -
Species: Human
Sample Types: Cell Lysates
S Nanjo et al. (2017), MET copy number gain is associated with gefitinib resistance in leptomeningeal carcinomatosis of EGFR-mutant lung cancer Mol. Cancer Ther, 0(0).
PMID: 28138027 -
Species: Mouse
Sample Types: Cell Lysates
R Adelaiye-O et al. (2017), EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming Cancer Res., 0(0).
PMID: 28978636 -
Species: Human
Sample Types: Cell Lysates
D Wang et al. (2017), Protein C receptor stimulates multiple signaling pathways in breast cancer cells J. Biol. Chem., 0(0).
PMID: 29217770 -
Species: Human
Sample Types: Cell Lysates
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Ito et al. (2015), Artificial human Met agonists based on macrocycle scaffolds. Nat Commun, 6(0):6373.
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Wu et al. (2015), Preclinical trials for prevention of tumor progression of hepatocellular carcinoma by LZ-8 targeting c-Met dependent and independent pathways. PLoS ONE, 10(1):e0114495.
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Heim E et al. (2015), Biologically active LIL proteins built with minimal chemical diversity. Proc Natl Acad Sci U S A, 112(34):E4717-25.
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Li L et al. (2014), An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII. Oncogene, 33(33):4253-64.
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Miyagawa-Yamaguchi et al. (2014), Expressed glycosylphosphatidylinositol-anchored horseradish peroxidase identifies co-clustering molecules in individual lipid raft domains. PLoS ONE, 9(3):e93054.
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Okon I et al. (2014), Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells. J Biol Chem, 289(3):1639-48.
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Carlino M et al. (2014), Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma. Mol Oncol, 8(3):544-54.
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Ugurel S et al. (2014), Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase II DeCOG trial with long-term follow-up. Clin Cancer Res, 20(2):499-510.
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Son M et al. (2014), Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency. Hum Mol Genet, 23(7):1802-16.
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Vultur A et al. (2014), MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines. Oncogene, 33(14):1850-61.
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Lei H et al. (2014), A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor alpha. Mol Cell Biol, 34(1):110-22.
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Wang et al. (2014), MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma. PLoS ONE, 9(5):e96765.
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Shiono et al. (2014), Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality. Sci Rep, 4(0):5927.
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Banerjee J et al. (2014), Improvement of human keratinocyte migration by a redox active bioelectric dressing. PLoS ONE, 9(3):e89239.
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Sakanyan V et al. (2014), Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells. Sci Rep, 4(0):3977.
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Skoda J et al. (2014), EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy. Oncol Rep, 31(1):480-7.
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Imura et al. (2014), Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma. Mol Cancer, 13(0):185.
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Cuenca-Lopez M et al. (2014), Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling. BMC Cancer, 14(0):302.
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Montero J et al. (2014), Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer. Oncogene, 33(2):148-56.
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Calero R et al. (2014), Sunitinib suppress neuroblastoma growth through degradation of MYCN and inhibition of angiogenesis. PLoS ONE, 9(4):e95628.
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Camorani S et al. (2014), Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRbeta aptamer. Mol Ther, 22(4):828-41.
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Lee H et al. (2013), Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration. Mol Cell Biol, 33(7):1430-41.
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de-Freitas-Junior J et al. (2013), Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. an interplay with E-cadherin. PLoS ONE, 8(11):e81579.
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Lekawanvijit S et al. (2013), The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction. PLoS ONE, 8(12):e83687.
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Britschgi A et al. (2013), Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Proc Natl Acad Sci U S A, 110(11):E1026-34.
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Davies et al. (2013), Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. PLoS ONE, 8(12):e82236.
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Kwon et al. (2013), Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. J Biol Chem, 288(37):26357-71.
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Krzyzaniak M et al. (2013), Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein. PLoS Pathog, 9(4):e1003309.
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Drake J et al. (2013), Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proc Natl Acad Sci U S A, 110(49):E4762-9.
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Bai Y et al. (2012), Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors. Cancer Res, 72(10):2501-11.
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Joshi et al. (2012), Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy. PLoS ONE, 7(10):e44372.
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Lin et al. (2012), Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PLoS ONE, 7(11):e49605.
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Oliveras-Ferraros C et al. (2012), Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells. Br. J. Cancer, 106(8):1406-14.
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Ball SG et al. (2012), Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency. Stem Cells, 30(3):548-60.
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(2012), Identifying and targeting ROS1 gene fusions in non-small cell lung cancer. Clin. Cancer Res., 18(17):4570-9.
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Purushothaman et al. (2012), Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. J Biol Chem, 287(49):41288-96.
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Duncan J et al. (2012), Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell, 149(2):307-21.
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(2012), Prostaglandin E(2) induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway. J. Immunol., 189(5):2563-73.
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Kotani N et al. (2012), Fibroblast Growth Factor Receptor 3 (FGFR3) Associated with the CD20 Antigen Regulates the Rituximab-induced Proliferation Inhibition in B-cell Lymphoma Cells. J Biol Chem, 287(44):37109-18.
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Ho A et al. (2012), PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma. Cancer Res, 72(17):4515-25.
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Gowrishankar K et al. (2012), Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition. J. Invest. Dermatol., 132(7):1850-9.
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Chakrabarty A et al. (2012), Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors. Proc. Natl. Acad. Sci. U.S.A., 109(8):2718-23.
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Lorenzon E et al. (2012), MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway. Oncogene, 31(26):3136-47.
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Poulikakos PI et al. (2011), RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature, 480(7377):387-90.
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Tanizaki J et al. (2011), Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification. Br. J. Cancer, 105(6):807-13.
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Godshalk SE et al. (2011), A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma. Oncogene, 30(13):1542-50.
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Csepeggi C et al. (2011), Somatic cell plasticity and Niemann-Pick type C2 protein: fibroblast activation. J. Biol. Chem., 286(3):2078-87.
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Henriksson ML et al. (2011), Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion. Am. J. Pathol., 178(3):1387-94.
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Karki R et al. (2011), The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation. PLoS Pathog., 7(4):e1001331.
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Tanabe H et al. (2011), Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2. Int. J. Oncol., 39(1):33-40.
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Ding VM et al. (2011), Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells. PLoS ONE, 6(3):e17538.
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Ou WB et al. (2011), Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma. Neoplasia, 13(1):12-22.
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Jiao Y et al. (2011), Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation. Mol. Cancer, 10(0):125.
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Carrasco-Garcia E et al. (2011), Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines. Exp. Cell Res., 317(10):1476-89.
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McKinley ET et al. (2011), 18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer. Clin. Cancer Res., 17(10):3332-40.
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Lupberger J et al. (2011), EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat. Med., 17(5):589-95.
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Tang WH et al. (2011), Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane. J. Clin. Invest., 121(11):4462-76.
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Csepeggi C et al. (2010), Somatic cell plasticity and Niemann-pick type C2 protein: adipocyte differentiation and function. J. Biol. Chem., 285(39):30347-54.
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Flanigan SA et al. (2010), The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models. Clin. Cancer Res., 16(22):5436-46.
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Villanueva J et al. (2010), Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell, 18(6):683-95.
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Strobel P et al. (2010), Sunitinib in metastatic thymic carcinomas: laboratory findings and initial clinical experience. Br. J. Cancer, 103(2):196-200.
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Ding W et al. (2010), Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch. Blood, 116(16):2984-93.
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Dewaele B et al. (2010), Coactivated platelet-derived growth factor receptor alpha and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma. Cancer Res., 70(18):7304-14.
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Nazarian R et al. (2010), Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature, 468(7326):973-7.
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Cook SA et al. (2010), Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction. Eur. Heart J., 31(1):100-11.
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Negri T et al. (2010), Functional mapping of receptor tyrosine kinases in myxoid liposarcoma. Clin. Cancer Res., 16(14):3581-93.
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Stacchiotti S et al. (2010), Sunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor response. Mol. Cancer Ther., 9(5):1286-97.
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Kang HG et al. (2010), Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells. Mol. Cancer Ther., 9(5):1396-407.
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Oliveras-Ferraros C et al. (2010), Pathway-focused proteomic signatures in HER2-overexpressing breast cancer with a basal-like phenotype: new insights into de novo resistance to trastuzumab (Herceptin). Int. J. Oncol., 37(3):669-78.
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Eiselleova L et al. (2009), A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells. Stem Cells, 27(8):1847-57.
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Yoon YK et al. (2009), Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells. Mol. Cancer Ther., 8(9):2526-36.
PMID: 19755509 -
Species: Human
Sample Types: Cell Lysates
Agarwal S et al. (2009), Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells. Br. J. Cancer, 100(6):941-9.
PMID: 19240716 -
Species: Human
Sample Types: Cell Lysates
Goldoni S et al. (2009), Decorin is a novel antagonistic ligand of the Met receptor. J. Cell Biol., 185(4):743-54.
PMID: 19433454 -
Species: Human
Sample Types: Cell Lysates
Eckstein N et al. (2009), Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res., 69(7):2996-3003.
PMID: 19318572 -
Species: Human
Sample Types: Cell Lysates
Kawaguchi K et al. (2009), Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells. Carcinogenesis, 30(7):1097-105.
PMID: 19380521 -
Species: Human
Sample Types: Tissue Homogenates
Stacchiotti S et al. (2009), Response to sunitinib malate in advanced alveolar soft part sarcoma. Clin. Cancer Res., 15(3):1096-104.
PMID: 19188185 -
Species: Human
Sample Types: Cell Lysates
Kobayashi T et al. (2009), Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells. Kidney Int., 75(11):1173-83.
PMID: 19242504 -
Species: Human
Sample Types: Cell Lysates
Kashiwagi K et al. (2009), A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells. Life Sci., 84(19):650-6.
PMID: 19232361 -
Species: Human
Sample Types: Cell Lysates
Marston E et al. (2009), Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response. Blood, 113(1):117-26.
PMID: 18941120 -
Species: Human
Sample Types: Cell Lysates
Franovic A et al. (2009), Human cancers converge at the HIF-2alpha oncogenic axis. Proc. Natl. Acad. Sci. U.S.A., 106(50):21306-11.
PMID: 19955413 -
Species: Human
Sample Types: Cell Lysates
Bax DA et al. (2009), EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines. Clin. Cancer Res., 15(18):5753-61.
PMID: 19737945 -
Species: Human
Sample Types: Cell Lysates
Kunii K et al. (2008), FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. Cancer Res., 68(7):2340-8.
PMID: 18381441 -
Species: Human
Sample Types: Cell Lysates
Agaram NP et al. (2008), Molecular characterization of pediatric gastrointestinal stromal tumors. Clin. Cancer Res., 14(10):3204-15.
PMID: 18483389 -
Species: Human
Sample Types: Cell Lysates
Mueller KL et al. (2008), Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells. Cancer Res., 68(9):3314-22.
PMID: 18451158 -
Species: Human
Sample Types: Cell Lysates
Shimamura T et al. (2008), Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res., 68(14):5827-38.
PMID: 18632637 -
Species: Human
Sample Types: Cell Lysates
Buck E et al. (2008), Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. Cancer Res., 68(20):8322-32.
PMID: 18922904 -
Species: Human
Sample Types: Tissue Homogenates
Yu L et al. (2008), Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. Mol. Med., 14(5):264-75.
PMID: 18231572 -
Species: Human
Sample Types: Cell Lysates
Koivunen JP et al. (2008), EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin. Cancer Res., 14(13):4275-83.
PMID: 18594010 -
Species: Human
Sample Types: Cell Lysates
Engelman JA et al. (2007), MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science, 316(5827):1039-43.
PMID: 17463250 -
Species: Human
Sample Types: Cell Lysates
Wang L et al. (2007), Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood, 110(12):4111-9.
PMID: 17761519 -
Species: Human
Sample Types: Cell Lysates
Eckstein N et al. (2007), Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells. J. Biol. Chem., 283(2):739-50.
PMID: 17942395 -
Species: Human
Sample Types: Cell Lysates
Fujikawa T et al. (2007), Des-gamma-carboxyl prothrombin-promoted vascular endothelial cell proliferation and migration. J. Biol. Chem., 282(12):8741-8.
PMID: 17255102 -
Species: Human
Sample Types: Cell Lysates
Kang HG et al. (2007), E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase. Cancer Res., 67(7):3094-105.
PMID: 17409416 -
Species: Human
Sample Types: Cell Lysates
Ball SG et al. (2007), Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol., 177(3):489-500.
PMID: 17470632 -
Species: Human
Sample Types: Cell Lysates
Stommel JM et al. (2007), Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science, 318(5848):287-90.
PMID: 17872411 -
Species: Human
Sample Types: Cell Lysates
Lomas AC et al. (2007), Fibulin-5 binds human smooth-muscle cells through alpha5beta1 and alpha4beta1 integrins, but does not support receptor activation. Biochem. J., 405(3):417-28.
PMID: 17472576 -
Cohen EE et al. (2006), Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res., 66(12):6296-303.
PMID: 16778206 -
Species: Human
Sample Types: Cell Lysates
Menendez JA et al. (2006), Trastuzumab in combination with heregulin-activated Her-2 (erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression. J. Clin. Oncol., 24(23):3735-46.
PMID: 16847284
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Customer Reviews for Proteome Profiler Human Phospho-RTK Array Kit (7)
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Verified Customer | Posted 08/31/2021Great, excellent, can't wait to start my experiences right away.
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Verified Customer | Posted 07/15/2021Purchased to screen changes induced by RTK inhibitors of cancer cell lines. Easy protocol, good clear results which could be independently validated by western blot. The only issue is that R&D are unable to supply information regarding the phospho-site detected, the antibody used in the array or the receptor chain recognised, so you just have to make an educated guess as to which antibody is most appropriate for an independent validation by western blotting etc. Excellent as an initial screen though.
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Verified Customer | Posted 11/18/2019I would recommend to my colleagues, nicely performed. (for image acquiring, I used ImageQuant LAS 4000)
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Verified Customer | Posted 03/13/2019
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Verified Customer | Posted 10/29/2018
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Verified Customer | Posted 08/28/2018The kit is excellent for p-RTK array in human cell lines. I recommended it to my colleague.
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Verified Customer | Posted 10/20/2017
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FAQs for Proteome Profiler Human Phospho-RTK Array Kit
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What are the phosphorylation site(s) of the 49 different tyrosine residues on the RTKs?
This kit uses a pan anti-phospho-tyrosine antibody as the detection antibody, which means it is capable of detecting phosphorylation at any available tyrosine. It is not designed to be specific for one phosphorylation site on each molecule. For instance, PDGF R alpha has multiple sites of tyrosine phosphorylation (see the “PTM/Processing” section of http://www.uniprot.org/uniprot/P16234 for a list of the currently identified sites).
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Can the Human Phospho-RTK Array be used for measuring the relative levels of total RTKs present in a sample?
No. Although the array kit uses capture antibodies that recognize both phosphorylated and unphosphorylated RTKs, the detection antibody is a pan anti-phospho-tyrosine antibody which only detects phosphorylated tyrosines on activated RTKs.
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To confirm positive signal for an RTK by IP-Western blot, are the capture antibodies from the Human Phospho-RTK Array Kit offered separately?
The identities of the capture antibodies on the Human Phospho-RTK Array are considered proprietary. However, to help investigators confirm their array results, Bio-Techne offers antibodies for each RTK detectable in the array kit. These antibodies are validated for Western blot and can be found in our catalog. A pan anti-phospho-tyrosine-HRP detection antibody is also available (Catalog # HAM1676).
