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Your Complete Solution for Targeted Protein Degradation

Bio-Techne offers a full range of products and services for Targeted Protein Degradation research and development, including Active Degraders (e.g. PROTAC degraders), TAG Degraders, Degrader Building Blocks, Ubiquitin-Proteasome System Proteins and Assays, Assays for Protein Degradation and Custom Degrader Services. 

Browse Products and Services

Active Degraders

PROTAC Degraders are a small molecule-based approach for the knockdown of target proteins within cells. 

Degrader Building Blocks

Bio-Techne provides chemical building blocks to support Degrader research and development.

TAG Degradation Platform

Our aTAG and dTAG platforms enable selective protein knockdown for target validation.

Custom Degrader Services

We offer a range of custom services for Degrader research and development.

Ubiquitin-Proteasome System Products

Explore our wide range of UPS-related proteins and assays.

Protein Degradation Assays

Our automated Western blot assay systems are rapid, gel-free, blot-free, hands-free.

Jess Simple Western instrument by ProteinSimple, a Bio-Techne brand

Meet Jess - Your Complete Protein Analysis Solution

Our Jess instrument automates the protein separation and immunodetection of traditional Western blotting, eliminating many of the tedious, error-prone steps. 

Targeted Protein Degradation Resources

Brochure: Targeted Protein Degradation Research

Our TPD Research Product Guide highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation research including, Active Degraders, Degrader Building Blocks, Custom Degrader Services, Proteins and Assays for protein degradation.

Video: What is Targeted Protein Degradation?

Our short animation explains the fundamentals of Targeted Protein Degradation (TPD) using small molecule Degraders or PROTACs, that harness the ubiquitin-proteasome system to selectively remove proteins from cell. 

Virtual Symposium: Targeted Protein Degradation

This virtual symposium brought together leading scientists in the field of Targeted Protein Degradation to discuss their recent research and provide insights  into PROTAC design, discovery and development, new research tools and expanding the E3 ligase toolbox.

Poster: Generating a Chemical Toolbox to Support PROTAC R&D

Authored by in-house experts, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each component are discussed. 

Research Paper: Developing Degraders: Principles and Perspectives

Tocris scientists have developed a set of guidelines relating to the physicochemical properties required in the design and synthesis of cell-permeable Degrader/ PROTAC molecules, which are reported in this paper in MedChemComm.

Publication Spotlight: Simple Western™ Assays & TPD Research

Learn how fully automated Simple Westerns are being used in research to measure Degrader-induced protein knockdown.

Background Information

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.