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Your Complete Solution for Targeted Protein Degradation

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Bio-Techne offers a full range of products and services for Targeted Protein Degradation research and development, including: small molecule Protein Degraders (e.g. PROTAC® degraders); aTAG and dTAG Degraders plus custom TAG knock-in cell lines; Degrader Building Blocks, Ubiquitin-Proteasome System Proteins and Assays; Assays for Protein Degradation and Custom Degrader Services.

Products and Services for Targeted Protein Degradation

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Target Validation and Exploration

Target validation, the process of establishing that a potential molecular target is involved in a physiological function or disease process, is a key step in the development of new Degraders, as well as for drug discovery and biological research. Our TAG Degradation platform offers a differentiated method for target validation, using targeted protein degradation to reversibly knockdown a potential protein target and enable exploration of the downstream phenotype.

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Degrader Design and Synthesis

Targeted protein degradation can be achieved using small molecule Protein Degraders, such as PROTAC® molecules. Bio-Techne provides a toolbox of products and services to support your Degrader Design and Synthesis program and save you time and money, including our PROTAC® Panel Builder online tool; a large range of off-the-shelf Degrader Building Blocks; and tools for new E3 ligase ligand discovery.

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Assays for Targeted Protein Degradation

Successful development of small molecule Protein Degraders for targeted protein degradation requires an array of assays to address a specific and differentiated set of questions aimed at characterizing aspects of Degrader activity. The assay workflow should explore: target engagement and ternary complex formation induced by the Degrader; ubiquitination of the target protein; as well as target degradation and its downstream consequences. Multiple orthogonal assays will maximize the chance of successful Degrader development. 

 

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E3 Ligase and Ubiquitin Proteasome System Biology

Bio-Techne through the R&D SystemsTM brand provides a wide range of products to help you explore and characterize ubiquitin biology. The rapidly expanding portfolio includes highly active E3 Ubiquitin Ligases, including SKP2, VHL, Cereblon (CRBN) and DCAF proteins, as well as assay kits and components, antibodies and Tandem Ubiquitin Binding Entities (TUBEs). We also provide Cullin-Rbx complexes (including neddylated cullins) that can be coupled to your purified substrate binding complexes to generate active ligases.

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Custom Services for Targeted Protein Degradation

Bio-Techne offers a unique portfolio of custom services to support your PROTAC® discovery and development and target validation programs. Harness our expertise in custom chemistry to develop active degraders to knock down your target of choice or custom building block panels. We also offer custom E3 ligase development services enabling you to build your own assays to investigate ubiquitination, and custom knock-in cell lines expressing your target protein of interest as a fusion with a "TAG" protein for use within our TAG degradation platform. 

Resources for Targeted Protein Degradation

Brochure: Targeted Protein Degradation Research

Our Targeted Protein Degradation Research Product Guide highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation research including, Active Degraders, Degrader Building Blocks, Custom Degrader Services, Proteins and Assays for protein degradation.

Webinar: Workflow Solutions for PROTAC® Degrader Development

Originally presented as a tech talk at Cell Bio Virtual 2020 by our Innovation Manager, Hannah Maple, PhD, this webinar presents how Bio-Techne can support your Degrader development program with our comprehensive workflow solution.

Virtual Symposium: Targeted Protein Degradation

This virtual symposium brought together leading scientists in the field of Targeted Protein Degradation to discuss their recent research and provide insights  into PROTAC design, discovery and development, new research tools and expanding the E3 ligase toolbox.

Paper: Reviewing the Toolbox for Degrader Development in Oncology

This review discusses the toolbox of guidelines, reagents, and technologies available to support Degrader research and development in oncology. 

Video: What is Targeted Protein Degradation?

This short animation explains the fundamentals of Targeted Protein Degradation (TPD) using small molecule Protein Degraders or PROTACs, that harness the ubiquitin-proteasome system to selectively remove proteins from cell. 

Application Note: Automated Profiling of PROTAC®-induced Degradation

Learn from Protein Simple how fully automated Simple Westerns can be used to profile degradation of cereblon neosubstrates using cereblon-recruiting Degraders and IMiDs.

Background Information

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.