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Your Complete Solution for Targeted Protein Degradation

Bio-Techne offers a full range of products and services for Targeted Protein Degradation research and development, including Active Degraders (e.g. PROTAC degraders), TAG Degraders, Degrader Building Blocks, Ubiquitin-Proteasome System Proteins and Assays, Assays for Protein Degradation and Custom Degrader Services. 

Browse Products and Services for Targeted Protein Degradation

Protein Degraders

PROTAC Degraders are a small molecule-based approach for the knockdown of target proteins within cells.

Degrader Building Blocks

Bio-Techne provides chemical building blocks to support Degrader research and development.

TAG Degradation Platform

Our aTAG and dTAG platforms enable selective protein knockdown for target validation.

Custom Degrader Services

We offer a range of custom services for Degrader research and development.

Ubiquitin-Proteasome System Products

Explore our wide range of UPS-related proteins and assays from R&D Systems.

Protein Degradation Assays

Our automated Western blot assay systems are rapid, gel-free, blot-free, hands-free.

Jess Simple Western instrument by ProteinSimple, a Bio-Techne brand

Meet Jess - Your Complete Protein Analysis Solution

Our Jess instrument automates the protein separation and immunodetection of traditional Western blotting, eliminating many of the tedious, error-prone steps. 

Targeted Protein Degradation Resources

Brochure: Targeted Protein Degradation Research

Our Targeted Protein Degradation Research Product Guide highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation research including, Active Degraders, Degrader Building Blocks, Custom Degrader Services, Proteins and Assays for protein degradation.

Video: What is Targeted Protein Degradation?

Our short animation on the Tocris website explains the fundamentals of Targeted Protein Degradation (TPD) using small molecule Degraders or PROTACs, that harness the ubiquitin-proteasome system to selectively remove proteins from cell. 

Virtual Symposium: Targeted Protein Degradation

This virtual symposium brought together leading scientists in the field of Targeted Protein Degradation to discuss their recent research and provide insights  into PROTAC design, discovery and development, new research tools and expanding the E3 ligase toolbox.

Webinar: Workflow Solutions for PROTAC® Degrader Development Programs

Originally presented as a tech talk at Cell Bio Virtual 2020 by our Innovation Manager, Hannah Maple, PhD, this webinar presents how Bio-Techne can support your Degrader development program with our comprehensive workflow solution.

Poster: Principles and Perspectives on Design and Chemical Space

Authored by in-house experts, this poster from provides a set of guidelines for Degrader development based on the structures of published Degrader molecules. 

Application Note: Automated Profiling of PROTAC®-induced Degradation

Learn from Protein Simple how fully automated Simple Westerns can be used to profile degradation of cereblon neosubstrates using cereblon-recruiting Degraders and IMiDs.

Your Favorite Genes ... In Your Favorite Cell™

Harness the expertise of our Cell and Genome Engineering team to generate cell lines for use within our TAG Degradation Platform for target validation. Our expert team will engineer cell lines to express your target protein of interest as a fusion with a TAG protein, enabling you to explore the downstream consequences of target knockdown using our dTAG and aTAG degrader molecules. 

DNA inside a cell

Background Information

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.