Skip to main content

Learn How Fully Automated Westerns Enable Cutting-Edge Targeted Protein Degradation Research

Scientific Articles

Targeted Protein Degradation (TPD) with heterobifunctional small molecule compounds (e.g., PROTAC®) is a novel approach to knockdown target proteins within cells. Degraders consist of binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker, and selectively remove proteins via the ubiquitin-proteasome system (UPS). Degraders have recently emerged as an attractive mechanism to explore previously “undruggable” targets. Advances in our understanding of how heterobifunctional Degraders achieve potency and selectivity will help to design more efficient degraders. Learn how fully automated Westerns with Simple Western™ enable cutting-edge targeted protein degradation research.

Simple Westerns used for targeted protein degradation research article