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Automated Profiling of PROTAC-Induced Cereblon Neosubstrate Degradation Using Simple Western

Application Notes

Application Notes Summary

Here, we present data showing the power of using automated Simple Western platforms to screen panels of Degrader and IMiD compounds in order to quantify degradation activity. In this study, we demonstrate the time savings achieved by automating these large screens as well as Simple Westerns ability to accurately quantify DC50 and Dmax values for specific Degraders and IMiDs.

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