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A Unique Range of Services for Targeted Protein Degradation Research

Bio-Techne offers a unique portfolio of custom services to support your PROTAC® discovery and development and target validation programs. Harness our expertise in custom chemistry to develop active degraders to knock down your target of choice, or access our custom degrader building blocks and custom building block panels capabilities to build you own degraders. We also offer biological testing of degraders to evaluate target knockdown, while our custom E3 ligase development services enable you to build your own assays to investigate ubiquitination in the presence of a degrader. For target validation, we offer custom knockin cell lines expressing your target protein of interest as a fusion with a "TAG" protein for use with our TAG degradation platform.  

Browse Our Custom Services for PROTAC® Discovery and Research

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Custom Degraders

We provide a wide range of off-the-shelf active degraders for your research, but if you can’t find what you’re looking for in our catalog, you can take advantage of our expertise in PROTAC® chemistry and partner with us for the custom design and synthesis of your active degrader of interest.

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Custom Degrader Building Blocks

We can also help you to build your own degraders by providing you with the building blocks you require. Our expert chemistry team is highly experienced in Degrader synthesis and can develop building blocks from different E3 ligase ligands and linkers of your choosing, not currently available off-the-shelf.

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PROTAC® Panel Builder

Our PROTAC® Panel Builder online tool allows you to rapidly generate a unique collection of functionalized E3 ligase ligands plus linkers of your choosing. Select any combination of E3 ligase ligand targeting Cereblon, VHL or IAP, with PEG or alkyl linker, and functional group to couple to your target ligand and we will send you a quote. Degrader development has never been easier!

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Custom Biological Testing

Use our Custom Biological Testing services to explore the performance of your Degraders for knockdown of the target protein of interest. We use our automated western blot systems (Simple WesternTM), to assess protein knockdown in your chosen cell line. The results offer proof of concept and can be used to explore further chemical optimization of your Degrader molecules.

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Custom E3 Ligases

Our Ubiquitin Proteasome Group provides superior quality Ubiquitin-Proteasome System Proteins/E3 Ligases enabling you to develop assays to investigate the activity of your Degraders on ubiquitination of substrate proteins. If you require a UPS Protein/E3 Ligase that is not on our website talk to our team about your research and take advantage of our industry leading experience in development and manufacturing of UPS proteins. 

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Custom Engineered Cell Lines

The TAG Degradation Platform (aTAG/dTAG) for target validation requires a cell line expressing your protein of interest as a fusion with a TAG protein. We can custom engineer knockin cell lines using our innovative editing technologies, including CRISPR-based aTAG, dTAG knockin, SNP edits, and TcBusterTM-facilitated large cargo knockin. We also provide knockout cell lines using CRISPR to generate site-specific edits to knockout your target gene(s). Our Custom Cell Lines are engineered and validated using Bio-Techne products you can trust.

Customer Success Stories

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.