Featured Recombinant Protein Products
Cytokines and Growth Factors
Cytokines and Growth Factors
• The most reliable source of recombinant proteins for immune cell, stem cell, and neural cell culture
• An unparalleled selection of recombinant proteins for studying interleukins, interferons, chemokines, and TNF superfamily members
• The highest quality, most consistent cytokines and growth factors for organoid cell culture
• Bulk and custom protein services to meet every researcher’s need
Immune Checkpoint Targets
Immune Checkpoint Targets
• Proteins for studying common targets including PD-1, PD-L1, and CTLA-4, and emerging targets such as TIGIT, LAG-3, Butyrophilins, and LILR family members
• Multiple tags available including Fc, His, and an expanding selection of Avi-tag biotinylated proteins
• Proteins for a range of different species including many non-human primate proteins with over 80 cynomolgus and rhesus monkey immune checkpoint proteins
• Bioactivity validated using a variety of different assays including cell proliferation or cytokine secretion assays, functional ELISA, or SPR
Avi-tag Biotinylated Proteins
Avi-tag Biotinylated Proteins
• Consistent labeling
• Uniform protein orientation
• Same high level of bioactivity as the unlabeled protein
• A large selection of immune checkpoint proteins
GMP Proteins
GMP Proteins
• Extensive documentation for traceability of source
• Rigorous lot-to-lot consistency testing against a master lot
• Additional quality control testing and quality assurance review
ProDots® Proteins
ProDots® Proteins
• R&D Systems proteins packaged into easy-to-use balls
• Eliminates aliquoting
• Reduces media preparation time
• Ensures optimal protein recovery
Bulk Proteins
Bulk Proteins
• The expertise and ability to scale up the production of almost any protein
• Specialized formulations available
• Economical pricing
Recombinant Protein Resources
Proteins Beyond the Catalog
Proteins Beyond the Catalog
If you don’t see the recombinant protein that you need listed on our website, contact us. We have tens of thousands of non-catalog proteins that may include different tags or come from different sources than similar proteins listed on our website.
Custom Protein Services
Custom Protein Services
For more specialized requests, contact our custom protein services team. Whether you are looking for a different formulation, incorporation of a non-standard label, or a specific mutated version of a protein, we have the capabilities and the team to develop the protein that you need.
Immune Cell Isolation and Culture Guide
Immune Cell Isolation and Culture Guide
Use this guide to explore the products that we offer for isolating, activating, differentiating, and culturing different immune cell types. From natural killer cells and macrophages to dendritic cells and T cells, we offer a wide selection of products to address all of your immune cell culture needs.
GMP Proteins for Therapeutic Manufacturing
GMP Proteins for Therapeutic Manufacturing
This brochure outlines the quality control processes and testing that goes into the production of our GMP-grade recombinant proteins. Learn more about how we ensure consistency and our capabilities for enhanced quality control testing, and explore our selection of GMP recombinant proteins.
Using Avi-tag Proteins to Determine Protein Interaction Kinetics by SPR
Using Avi-tag Proteins to Determine Protein Interaction Kinetics by SPR
See how R&D Systems Avi-tag biotinylated proteins can be used to generate useful kinetic and affinity measurements by surface plasmon resonance.
Current and Emerging Immune Checkpoint Targets eBook
Current and Emerging Immune Checkpoint Targets eBook
This eBook details some of the current and emerging immune checkpoint molecules that are being investigated as potential immuno-oncology targets, and it highlights the products that we offer for studying these molecules, including PD-1, PD-L1, CTLA-4, B7 family proteins, butyrophilins, LAG-3, TIGIT, TIM-3, and co-stimulatory TNF receptor superfamily members.
Background Information
R&D Systems: The Most Trusted Source for Recombinant Proteins
Bio-Techne offers more than 5,000 R&D Systems® recombinant proteins for a variety of different research areas including immunology, cancer, development, neuroscience, and stem cells. With over 30 years of experience, R&D Systems’ rigorous in-house testing and quality control specifications ensure that our recombinant proteins will provide industry-leading bioactivity and purity, lot-to-lot consistency, and low endotoxin levels. As more than 95% of the proteins in our catalog are manufactured in-house, we maintain complete control over the quality of our products and the satisfaction of our customers, which is our number one priority.
To guarantee that each protein meets our customers’ high standards, we fully assess and report the specifications of each protein on our datasheets, including the activity, endotoxin level, and purity. The bioactivities of our proteins are assessed using a variety of different assays depending on the protein being tested. These include cell proliferation, chemotaxis, or cytokine secretion assays, enzymatic assays, functional ELISAs, and surface plasmon resonance (SPR). N-terminal sequence analysis is also performed for each recombinant protein to confirm that the protein produced matches the expected sequence, and the bioactivity and physical state of our proteins are monitored over long periods of time. Freeze/thaw cycles are carried out to ensure that the buffer provides for long-term stability. Additionally, we evaluate lot-to-lot consistency so that researchers don’t have to worry about whether or not their experiments will be reproducible over time. Multiple lots with matching specifications are created for all new proteins and each new lot is tested side-by-side with previous lots to ensure that the new lots display the same level of bioactivity and purity as the previous lots. Each new lot is also tested to make sure that it meets our expectations for endotoxin specifications, which is an industry-leading <0.1 EU/µg. Finally, all of our recombinant proteins are specially formulated for the best stability and are lyophilized from a sterile filtered solution. If our documentation fails to address any questions that you may have about our products, our protein scientists and highly trained technical service team at R&D Systems are always available to assist you.
Our catalog includes recombinant proteins for multiple different species, that are either untagged or have a biotin, Fc, or His tag. We also offer an expanding line of Avi-tag biotinylated proteins. Our standard recombinant proteins are available without or with a carrier protein, which is typically bovine serum albumin (BSA) at a concentration of 50 µg BSA per 1 µg of protein. The presence of the carrier protein gives the lyophilized protein greater stability, maximizes recovery upon reconstitution, and allows easy handling and storage. In addition to the wide selection of proteins that are manufactured under standard conditions, our portfolio also includes R&D Systems Animal-Free™ and GMP-grade recombinant proteins, ProDots® proteins, and custom protein development services.