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Key Benefits Our Recombinant Proteins Offer to Customers

Featured Recombinant Protein Products

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Cytokines and Growth Factors

• The most reliable source of cytokines and growth factors for immune cell, stem cell, and neural cell culture

• An unparalleled selection of recombinant proteins for studying interleukins, interferons, chemokines, adipokines, and TNF superfamily members

• The highest quality, most consistent cytokines and growth factors for organoid cell culture

Bulk and custom protein services to meet every researcher’s need


Immune Checkpoint Proteins

• Proteins for studying common targets including PD-1, PD-L1, and CTLA-4, and emerging targets such as TIGIT, LAG-3, Butyrophilins, and LILR family members

• Multiple tags available including Fc, His, and an expanding selection of Avi-tag biotinylated proteins

• Proteins for a range of different species including many non-human primate proteins with over 80 cynomolgus and rhesus monkey immune checkpoint proteins

• Bioactivity validated using a variety of different assays including cell proliferation or cytokine secretion assays, functional ELISA, or SPR


Mutant SARS-Cov-2 Spink protein variants

Proteins for Coronavirus Research

• Our catalog includes a large selection of SARS-CoV-2 Spike proteins that exhibit high levels of ACE-2 binding activity and purity 

• Multiple SARS-CoV-2 Spike mutant proteins are available, including the Alpha, Beta, Gamma, Delta, Lambda, and Mu variants

• Rigorous lot-to-lot consistency testing ensures each new lot displays the same level of bioactivity and purity as previous lots

• Scalable production capabilities to meet manufacturing needs

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Avi-tag and Amine-Labeled Biotinylated Proteins

• Avi-tag biotinylated proteins incorporate a single biotin within the Avi-tag to provide consistent labeling and uniform protein orientation for binding assays

• Amine-labeled biotinylated proteins incorporate multiple biotins per molecule, allowing for high signal strength and binding efficiency

• All R&D Systems™ biotinylated proteins are rigorously tested to ensure that they exhibit the same level of bioactivity as the unlabeled protein and exhibit minimal lot-to-lot variability

Fluorokine CAR T Cells

Fluorokines™ Fluorescent-Labeled Proteins

• Fluorokines are highly specific and allow target molecules to be directly stained and detected by flow cytometry

• They are conjugated to Alexa Fluor® or Atto dyes, which offer intense fluorescence and excellent photostability

• Fluorokines undergo rigorous testing to ensure specificity, bioactivity, and lot-to-lot consistency

• Fluorokines are compatible with antibody panels for multi-color flow cytometry

GMP Protein Bottles

GMP Proteins

• Extensive documentation for traceability of source

• Rigorous lot-to-lot consistency testing against a master lot

• Additional quality control testing and quality assurance review



Serum-Free and Animal-Free Cell Culture


Increase the consistency of your cell cultures as you approach translational studies for regenerative medicine and cell therapy programs. Adopting these media will

  • Reduce variability in media composition
  • Simplify compliance with regulatory guidelines
  • Simplify comparability testing for raw material changes
Adherent cells in culture supported by extracellular matrix

Customer Success Stories

Recombinant Protein Resources

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Proteins Beyond the Catalog

If you don’t see the recombinant protein that you need listed on our website, contact us. We have tens of thousands of non-catalog proteins that may include different tags or come from different sources than similar proteins listed on our website.

Thumbnail image from the White Paper: Levels and Neutralizing Ability of Abs in COVID-19 Patients and Vaccinated Individuals

Neutralizing Ability of Abs in COVID-19 Patients and Vaccinated People

Current COVID-19 vaccine preparations use sequences of the wild-type SARS-CoV-2, and do not include mutations of variants that exhibit higher transmissibility than the wild-type virus. Read this white paper to see how well neutralizing antibodies against the original SARS-CoV-2 wild-type virus block the ability of Spike protein variants to associate with ACE-2 in vitro.

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The Road to Research Success

This infographic shows how Bio-Techne products, and our consistency to quality, will help you advance your research efforts. What tools are you using in your research? Good results are everything. Trust your reagents.

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Proteins for Stem Cell Culture

Optimize your stem cell cultures with R&D Systems™ cytokines and growth factors. Our proteins provide high levels of bioactivity and lot-to-lot consistency so you can be confident that they will promote robust stem cell expansion and differentiation with minimal variability between cultures. From basic research to preclinical applications, we offer research-grade, Animal-Free™, and GMP-grade cytokines to meet all of your experimental needs.



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Current and Emerging Immune Checkpoint Targets eBook

This eBook details some of the current and emerging immune checkpoint molecules that are being investigated as potential immuno-oncology targets, and it highlights the products that we offer for studying these molecules, including PD-1, PD-L1, CTLA-4, B7 family proteins, butyrophilins, LAG-3, TIGIT, TIM-3, and co-stimulatory TNF receptor superfamily members.

Image of a cytokine-secreting cell

Cytokine Families

Explore the Cytokine Family pages on our website to learn more about why specific cytokines are grouped into families including detailed information about their structures, their receptor complexes, the signaling pathways that they activate, and their functions. These pages contain the most up-to-date listings of related products for each cytokine family along with data examples and featured resources.

Background Information

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Gene Engineering Services

Realize the potential of gene engineering by partnering with our experts. Engineer any cell type including T cells and iPSC with our non-viral TcBuster™ gene delivery system.

For cell and gene therapy manufacturing, we offer services that include process development for cell engineering, quality control, custom cell vialing, and regulatory support.

View Gene Engineering Services

Alexa Fluor® is a registered trademark of Molecular Probes, Inc., Eugene, OR.