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GMP Small Molecules as Ancillary Reagents

Stem cells offer great potential for use as therapies in regenerative medicine. They can be used to generate cells to replace lost or unhealthy cells in a wide range of conditions including trauma, diabetes and Parkinson’s disease. The small molecules used as ancillary materials in the generation of stem cell therapies are required to be safe, reliable, consistent and quality-assured in order to ensure the safety of the stem cell therapy. Our GMP Small Molecules, manufactured according to cGMP guidelines, provide this assurance.

GMP Small Molecules

Product Name

Catalog #

Description

CHIR 99021

TB4423-GMP

GSK-3 Inhibitor; WNT pathway activator. Enables reprogramming of human somatic cells into iPSCs

SB 431542

TB1614-GMP

TGF Beta 1 (TGF-β1), ALK4 and ALK7 Inhibitor. Replaces SOX2 in reprogramming of fibroblasts to iPSCs

XAV 939

TB3748-GMP

Tankyrase Inhibitor; inhibits WNT signaling. Promotes cardiomyocyte differentiation from ESCs

Y-27632

TB1254-GMP

Selective ROCK Inhibitor. Increases survival of ESCs and iPSCs undergoing cryopreservation

Additional GMP Products and Services

Proteins

GMP Cytokines and Growth Factors

Our large portfolio of GMP proteins is backed by our dedication to providing cell therapy manufacturers with a consistent, safe, and traceable supply of reagents.

Antibody

Custom GMP Antibodies

Our GMP antibodies are manufactured recombinantly for use in drug discovery, diagnostic, and cell & gene therapy manufacturing processes.

 

Cloudz Cell Activation Kit

GMP Cloudz Cell Activation Kits

Cloudz kits are based on dissolvable alginate beads decorated with cell type-specific antibodies. They induce feeder-free activation and expansion of specific immune cell subsets.

GMP Cell Manufacturing and Process Development

We offer process development services for any gene modified therapy, GMP patient processing for Phase I and Phase II clinical trials, and GMP manufacturing of iPSC cell lines.

GMP Small Molecule Resources

Brochure: Pioneering Cell & Gene Therapy Solutions

Our brochure provides an overview of the innovative products and services available from Bio-Techne to help further your cell and gene therapy research. 

Poster: Stem Cell Workflow Using Small Molecules

Our Tocris Stem Cell Workflow poster summarizes how small molecules have been used in protocols across the stem cell workflow, and highlights some of the key advantages of using small molecules. 

Stem Cells

Protocols: Key Stem Cell Protocol Highlights

Our Stem Cell Protocol snapshots highlight how small molecules may be used in place of or alongside proteins in cell culture, reprogramming and differentiation procedures. 

About GMP Small Molecules

GMP small molecules are important in the manufacture of stem cell therapies for translational research and clinical applications, where they are used as ancillary reagents. Ancillary reagents are utilized in the growth and manipulation of stem cells. Although they are not intended to be present in the final cell therapy product, they may influence its safety, so the use of GMP ancillary reagents is advisable. 

The clinical phases of development of any therapy are highly regulated in order to mitigate the risk to patient safety, and this includes the use of GMP ancillary reagents (raw materials) for developing stem cell therapies. Our GMP small molecules are manufactured following relevant sections of ICH Q7 guidelines (Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients), which ensures batch-to-batch consistency, traceability from starting material to final product and animal-free production.

View Our Cell and Gene Therapy Resources

Background Information