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Protein Charge Analysis with icIEF on capillary electrophoresis platform Maurice

Protein Charge Analysis with icIEF

Reproducible charge heterogeneity analysis under 10 minutes with whole-column imaging using Maurice or Maurice C.

Looking for iCE3? Visit us here.

Protein Size Analysis with CE-SDS on capillary electrophoresis platform Maurice from ProteinSimple

Protein Size Analysis with CE-SDS

Automated and highly quantitative analysis of protein purity in as little as 5.5 minutes with Maurice or Maurice S.

Maurice: One Instrument for CE-SDS and cIEF

See How Maurice Makes Protein Analysis Easy

 

We know you’re always looking to simplify and amplify your therapeutic development, and we’re here to help you do just that! Meet Maurice, our analytical CE instrument that lets you profile your molecules for both charge and size. No tedious sample prep, instrument set-up, or clean-up. Just plug in a cIEF or CE-SDS cartridge, hit Start, and get the high-quality data you need in a snap.

 

What Maurice Can Do For You

Pain Point: Save Time

Save Time

Method development in a day, charge data in 10-15 minutes, and size data in as little as 5.5 minutes all add up to huge time savings, giving you time back to focus on other parts of your research.

Pain Point: Simplify Science

Simplify Science

Load your samples, insert the cartridge, and let Maurice take care of the rest. Swapping between cIEF and CE-SDS is as simple as taking one cartridge out and putting the next in. It doesn’t get easier than that.

Pain Point: Save Your Samples

Save Your Samples

Maurice only needs 50 uL of sample for analysis - letting you preserve all your precious samples.

Pain Point: Data You Can Trust

Get Data You Can Trust

You can’t afford bad or unreliable data. Maurice gives you the resolution and reproducibility you need to make confident decisions.

Pain Point: Stay Compliant

Stay Compliant

Be assured that you’re generating 21CFR Part 11 compliant data with Compass for iCE software or Waters™ Empower®.

Maurice Virtual Demo

 

Come explore and see how easy it is to measure charge and size heterogeneity with Maurice.

 

ProteinSimple Maurice Demo Intro

iCE Instruments for cIEF and CE-SDS

Maurice capillary icIEF and CE-SDS proteinsimple Instrument

Maurice

One-stop cIEF and CE-SDS

Purity, identity and heterogeneity analysis

Maurice S Instrument from Protein Simple CE-SDS capillary electrophoresis platform

Maurice S.

Ready-to-go Turbo CE-SDS or CE-SDS PLUS

Simplifies size separation workflows

Maurice C ic-IEF Instrument capillary isoelectric focusing platform

Maurice C.

cIEF data in a snap

Identity and charge heterogeneity

iCE platforms iCE3 and Maurice from ProteinSimple a Bio-Techne brand

Switch from iCE3 to Maurice

Maurice does everything that your iCE3 does, only faster and easier. 

iCE Consumables - Maurice consumables

iCE Consumables

You can now order consumables for Maurice and iCE online

Turbo CE-SDS cartridge for iCE platform Maurice

CE-SDS just got 80% faster

With Turbo CE-SDS get high-quality size analysis in as little as 5.5 minutes for high-throughput applications.

iCE Applications

Bioprocessing

Bioprocessing

Whether it is during clone selection or final product characterization, use a hassle-free, robust, and fast method to characterize the charge and size profiles of your therapeutic.

CE-SDS

CE-SDS

Get automated, reproducible, and high-throughput size analysis in as little as 5.5 minutes per sample.

Cell & Gene Therapy

Cell & Gene Therapy

Next-generation analytical instrumentation to help improve and accelerate your cell and gene therapy workflows.

Protein Charge Heterogeneity

Protein Charge Heterogeneity

High-quality absorbance and native fluorescence give you charge heterogeneity data for even the most complex proteins with automated, whole-column cIEF.

Protein Stability and Formulation Testing

Protein Stability and Formulation Testing

Understand the impact of protein changes on drug safety and efficacy and develop the best formulation for your therapeutic with cIEF analysis.

Protein and Antibody Characterization

Protein & Antibody Characterization

Rapidly and accurately monitor the charge and molecular weight heterogeneity of your proteins, two critical properties that inevitably change during development.

Post-translation Modification

Post-translation Modification

To know if your proteins have undergone deamidation, oxidation, glycation, or another other post-translational modification, get accurate data on their changing isoelectric points.

Biosimilars

Biosimilars

Gain confidence in your biosimilars by getting accurate, high-quality data on the charge and size profiles of your proteins and antibodies.

Vaccine

Vaccine Development

Whether you’re working with LNPs or viral vectors, confirm their charge heterogeneity, identity, and purity, and proceed confidently with your vaccine development.

Which Maurice is right for you?

 

 

System

Maurice

Maurice C.

Maurice S.

cIEF Charge Application

Yes

Yes

No

CE-SDS Size Application

Yes

No

Yes

Absorbance Detection

Yes

Yes

Yes

Fluorescence Detection

Yes

Yes

No

Onboard Mixing for Sample Prep

Yes

Yes

No

Specifications

 

Description

cIEF Specification

CE-SDS Plus Specification

Turbo CE-SDS

Minimum Sample Volume

50 µL

50 µL

100 µL

Sample Delivery

Vacuum

Electrokinetic

Electrokinetic

Typical Separation Time

6-10 min (molecule-dependent)

Reduced: 25 minutes; Non-reduced: 35 minutes

Reduced: 5.5 minutes; Non-reduced: 8 minutes

Detection Capability

Pre-focusing: 1500 V, focusing: 3000 V

Separation: 5750 V

UV Abs at 220 nm

Sample Injections per Cartridge

100 guaranteed, 200 maximum

500 maximum for CE-SDS PLUS

100 guaranteed, maximum 25 batches

Maximum Sample Injections per Batch

100

48

96

pI/Size Range

2.85-10.45

10-270 kDa

10-270 kDa

pI/Sizing CV

1%

≤2%

<2%

CV for Peaks >10% Composition

≤5% (Intra-batch), ≤6% (Inter-batch)

N/A

N/A

pI/Sizing Resolution

0.05 pl units (for wide range 3-10 ampholyte)

≥ 1.5 for NGHC/HC IgG Standard)

≥ 1.0 for NGHC/HC IgG Standard)

Dynamic Range

2 logs

2 logs

2 logs

Linearity

>0.995

>0.995

>0.995

Sensitivity (LOD)

0.7 µg/mL (Native fluorescence)
3.0 µg/mL (Absorbance) (Values based on a monoclonal antibody)

0.3 µg/mL
(Value based on internal standard)

0.6 μg/mL (value based on internal standard)

Sample Tray Options

96-well plates or 48 vials

96-well plates or 48 vials

96-well plates or 48 vials

Power

100 V-240 V (AC), 50/60 Hz, 500 W

100 V-240 V (AC), 50/60 Hz, 500 W

100 V-240 V (AC), 50/60 Hz, 500 W

Temperature Control Range

4-25 °C

4-25 °C

4-25 °C

Dimensions

44cm H x 42cm W x 61cm D

44cm H x 42cm W x 61cm D

44cm H x 42cm W x 61cm D

Weight

46 kg (100 lb)

46 kg (100 lb)

46 kg (100 lb)