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iCE™ platforms perform imaged capillary isoelectric focusing (cIEF) and capillary electrophoresis sodium dodecyl sulfate (CE-SDS) for reproducible, quantitative analysis of identity, purity, and heterogeneity profiles for your therapeutic proteins. And they do it fast—we're talking results in 15 minutes or less per sample! You'll also get high resolution, full-on automation, and none of the hassles that come with other IEF techniques. Maurice platforms also automate size separations for you, so you'll get robust and quantitative analysis for your monoclonal antibodies too.
iCE Instruments for cIEF and CE-SDS
Maurice
Maurice
One-stop cIEF and CE-SDS
Purity, identity and heterogeneity analysis
Maurice S.
Maurice S.
Ready-to-go CE-SDS or CE-SDS PLUS
Simplifies size separation workflows
Which imaged cIEF/CE-SDS system is right for you?
System |
Maurice |
Maurice C. |
Maurice S. |
iCE3 |
|---|---|---|---|---|
cIEF Charge Application |
Yes |
Yes |
No |
Yes |
CE-SDS Size Application |
Yes |
No |
Yes |
No |
Absorbance Detection |
Yes |
Yes |
Yes |
Yes |
Fluorescence Detection |
Yes |
Yes |
No |
No |
Onboard Mixing for Sample Prep |
Yes |
Yes |
No |
Yes* |
Description |
cIEF Specification |
CE-SDS Specification |
|---|---|---|
Minimum Sample Volume |
50 µL |
50 µL |
Sample Delivery |
Vacuum |
Electrokinetic |
Typical Separation Time |
6-10 min (molecule-dependent) |
UV Absorbance at 220 nm |
Detection Capability |
Pre-focusing: 1500 V, focusing: 3000 V |
Separation: 5750 V |
Sample Injections per Cartridge |
100 guaranteed, 200 maximum |
100 guaranteed, 200 maximum for CE-SDS, 500 maximum for CE-SDS PLUS |
Maximum Sample Injections per Batch |
100 |
48 |
pI/Size Range |
2.85-10.45 |
10-270 kDa |
pI/Sizing CV |
1% |
≤2% |
CV for Peaks >10% Composition |
≤5% (Intra-batch), ≤6% (Inter-batch) |
N/A |
pI/Sizing Resolution |
2 logs |
2 logs |
Dynamic Range |
2 logs |
2 logs |
Linearity |
>0.995 |
>0.995 |
Sensitivity (LOD) |
0.7 µg/mL (Native fluorescence) |
0.3 µg/mL |
Sample Tray Options |
96-well plates or 48 vials |
96-well plates or 48 vials |
Power |
100 V-240 V (AC), 50/60 Hz, 500 W |
100 V-240 V (AC), 50/60 Hz, 500 W |
Temperature Control Range |
4-25 °C |
4-25 °C |
Dimensions |
44cm H x 42cm W x 61cm D |
44cm H x 42cm W x 61cm D |
Weight |
46 kg (100 lb) |
46 kg (100 lb) |
