Maurice
Your workhorse station for purity, identity and heterogeneity analysis
Purity, identity and heterogeneity
Still spending weeks or months on method development for your biologics? This new advanced CE platform lets you easily switch between cIEF and CE-SDS applications and develop platform methods within a day. In this short video, the people behind the gold-standard iCE technology highlight the key benefits of the new platform for CE analysts. Find out how Maurice makes CE easy with his streamlined workflow and delivers identity, purity and heterogeneity data on your biologics fast.
More Information About Maurice
Feature | cIEF Specification | CE-SDS Specificiation |
---|---|---|
Minimum Sample Volume | 50 µL | 50 µL |
Sample Delivery | Vacuum | Electrokinetic |
Typical Separation Time | 6–10 min (molecule-dependent) | Reduced IgG: 25 min, Non-reduced IgG: 35 min |
Detection Capability |
UV Absorbance at 280 nm Fluorescence: Ex 280 nm, Em 320– 450 nm |
UV Absorbance at 220 nm |
Typical Voltage | Pre-focusing: 1500 V, focusing: 3000 V | Separation: 5750 V |
Sample Injections per Cartridge | 100 guaranteed, 200 maximum | 100 guaranteed, 200 maximum for CE-SDS, 500 maximum for CE-SDS PLUS |
Maximum Sample Injections per Batch | 100 | 48 |
pI/Size Range | 2.85–10.45 | 10–270 kDa |
pI/Sizing CV | 0.01 | ≤2% |
CV for Peaks >10% Composition | ≤5% (Intra-batch), ≤6% (Inter-batch) | N/A |
Relative Migration Time CV | N/A | <1% for reduced IgG |
pI/Sizing Resolution | 0.05 pI units (for wide range 3–10 ampholytes) | ≥1.5 for NGHC/HC IgG Standard |
Dynamic Range | 2 logs | 2 logs |
Linearity | >0.995 | >0.995 |
Sensitivity (LOD) | 0.7 µg/mL (Native fluorescence) 3.0 µg / mL(Absorbance) (Values based on a monoclonal antibody) | 0.3 µg/mL (Value based on Internal Standard) |
Sample Tray Options | 96-well plates or 48 vials | |
Dimensions | 44cm H x 42cm W x 61cm D | |
Weight | 46 kg (100 lb) |