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New Small Molecules & Peptides

AP 20187 | 6297

  • Chemical inducer of dimerization (CID) for use in FKBP fusion protein systems
  • Induces apoptosis in cells expressing a fusion protein consisting of FKBPF36V and intracellular domain of Fas receptor, Fas-associated death domain (FADD), or a caspase
  • Active in vivo

Miro1 Reducer | 7091

  • Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1)
  • Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients
  • Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs

GRL 0617 | 7280

  • Coronavirus papain-like protease (PLpro) inhibitor
  • Inhibits deubiquitination activity of SARS-CoV PLpro with no effect on human deubiquitinating enzymes
  • Inhibits SARS-CoV-2 viral replication in vitro

Featured Small Molecule Product Types

Compound Libraries

The TocriscreenTM range of bioactive compound libraries are collections of small molecules designed for use in assays for target validation, tool compound identification, receptor de-orphanization and assay development. The range includes libraries covering a diverse range of research areas and targets, as well as focused libraries for specific targets and drug repurposing. 

Chemogenetics

Chemogenetic compounds, such as DREADD ligands and PSEMs, act at genetically modified GPCRs and ion channels, respectively. They enable control of neuronal activity, and investigation of downstream signaling pathways, by initiating a signal cascade from a GPCR or opening of an ion channel pore. 

Fluorescent Probes and Dyes

Fluorescent probes and dyes allow visualization of intracellular structures and individual proteins, and determination of cell types, in live and fixed cells with high sensitivity and selectivity. Our range includes Janelia Fluor® Dyes, cytoskeletal and microtubule probes as well as innovative probes for imaging bacteria. 

Featured Small Molecule Research Resources

Tocris Stem Cell Product Guide

NEW Stem Cell Research Guide

Our new product guide provides a review of how small molecules have been used in stem cell research and lists over 200 products for differentiation, reprogramming and organoid generation, to support your research in the field.

SARS-CoV-2

Small Molecules for COVID-19 Research

Explore compounds for the investigation of viral cell entry, viral replication and cytokine storm in SARS-CoV-2 infection in our new research area. 

Products by Application, Type or Technique

Background Information