Find Ligands for your Target
Search for your target in the search bar above or Browse pharmacology groups below on tocris.com
Our comprehensive range includes agonists, antagonists, partial agonists, DREADD ligands, caged compounds, NAMs, PAMs, biased agonists and fluorescent probes targeting over 30 families of G protein-coupled receptors (GPCRs)/7-Transmembrane receptors (7-TMs), including 5-HT, Glutamate and Dopamine receptors.
Our expansive collection of small molecule and peptide ligands target both the receptor and enzyme components of the five main types of enzyme-linked receptors, including RTKs, RSTKs, and toll-like receptors.
Our expansive enzymes range includes activators, substrates, inhibitors and fluorescent probes targeting over 25 different enzyme families, including ATPases, hydrolases, phosphodiesterases and transferases.
We offer an expansive collection of activators, blockers and modulators, PSEMs, and caged compounds that can manipulate several classes of ion channels including calcium channels, ligand-gated ion channels and potassium channels.
Our range of small molecules and peptides includes agonists, antagonists, modulators and fluorescent probes, which regulates the activity of over 20 types of nuclear receptors, including androgen, estrogen receptors, glucocorticoid and vitamin D receptors.
Our transporter collection comprises inhibitors, activators, substrates and fluorescent probes, which target glucose, multidrug and neurotransmitter transporters, as well as ion pumps including Na+/Ca2+ exchangers and monocarboxylate transporters.
Other Pharmacology Targets
Targets include adenine receptors, antibiotics, antivirals, antioxidants, immunosuppressants, imidazoline receptors and sigma receptors among other targets, as well as miscellaneous compounds. View targets on tocris.com
Rapid and Reproducible Pharmacokinetic Quantification
Simple Western™ fully automates CE-SDS/cIEF and immunodetection using conventional Western blot antibodies. With 96 samples processed overnight, Simple Western will calculate IC/EC50, LOD, LOQ, and more with intra- and inter-assay CVs of <20%, even in complex samples like human serum and tissue homogenates.
Bio-Techne brands R&D Systems and Novus Biologicals, offer 780,000 antibodies which have been validated in over 25 species for more than 15 applications.
Electrophysiology techniques measure the electrical current or voltage changes across cells or tissue samples. Electrical activity can be modulated using ion channel modulators, DREADD ligands, PSEMs, GPCR ligands and caged compounds.
Bio-Techne offer a wide range of immunoassay kits and reagents, including, Luminex™ multiplexing assays, the gold standard Quantikine® ELISA kits, ELLA™ automated ELISA, and the Proteome Profiler™ Arrays.
Pharmacology Resources at tocris.com
Use our calculators to plan your experiments:
- Molarity Calculators
- Dilution Calculators
- Reconstitution Calculators
Pharmacodynamics and Pharmacokinetics
Pharmacology is split into two main areas, pharmacodynamics and pharmacokinetics. Pharmacodynamics is the study of drugs and their interactions on biological systems. It encompasses drug design and characterization of drugs (e.g. small molecules or peptides). Pharmacokinetics interrogates the effects of biological systems on drug action, studying how a drug is metabolized, absorbed and trafficked into and around the body, as well as the mechanism for drug clearance.
The word drug, as used on this website, is intended to mean small molecules or peptides that affect biological function. If drugs have medical applications, they are termed pharmaceuticals.
Pharmacology Product Ranges
Bio-Techne has a long legacy in supporting pharmacology research with high quality small molecules and peptides. Tocris, a Bio-techne brand, started out as a pharmacology company in 1982, when Professor Jeff Watkins from the University of Bristol, UK, made glutamate compounds commercially available to the wider scientific community. The first compounds manufactured and sold were DL-AP4 (Cat. No. 0101), a broad spectrum excitatory amino acid (EAA) ligand, and D-AP4 (Cat. No. 0102) and L-AP4 (Cat.No. 0103), DL-AP4’s two isomers.
Bio-Techne provides pharmacological research tools for all main research areas including cancer, cardiovascular systems, cell and gene therapy, endocrinology, immunology, neuroscience, pain and inflammation infectious diseases and respiratory systems. Our catalog includes a comprehensive range of gold standard reagents and cutting edge tools such as photoswitchable ligands, DREADD ligands, PSEMs, stapled peptides and PROTAC® Degraders. We pride ourselves on being first to market with the latest technologies and tools. Our world class team of PhD qualified scientists, collaborate with industry and academia to ensure we are able to make the latest tools commercially available to scientists in a timely manner.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Pharmacology Resources and Literature
We produce and provide a large range of free scientific posters, product guides, product listings and scientific reviews to request or download at tocris.com. These pieces are authored by experts in their field. Two exceptional posters that highlight some of the most recent advances in pharmacological theory are the Allosteric GPCR Pharmacology poster and GPCR Efficacy and Biased Agonism poster, authored by Professor Arthur Christopoulos, Professor Patrick Sexton, David Thal and Denise Wootten. These pieces discuss the latest GPCR signaling pharmacology and highlights therapeutic applications of ligands with different efficacies as well as biased agonism, PAMS and NAMs.
We also have a range of in-house authored scientific meeting posters and scientific bulletins including the popular Chemogenetics bulletin, which gives a clear and concise introduction into chemogenetic methods to manipulate neuronal activity.
Finally we have a selection of informative blogs covering a range of research areas including developing chemical probes for epigenetic targets and targeting the immune system in cancer with small molecules. Check out the full range of titles.
Gene Engineering Services
Realize the potential of gene engineering by partnering with our experts. Engineer any cell type including T cells and iPSC with our non-viral TcBuster™ gene delivery system.
For cell and gene therapy manufacturing, we offer GMP CDMO services that include process development for cell engineering, quality control, custom cell vialing, and regulatory support.