D-AP4

Tocris Bioscience a Bio-Techne Brand

Catalog # 0102

Citations (3)

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Key Product Details

Description:	Broad spectrum glutamatergic antagonist
Chemical Name:	D-(-)-2-Amino-4-phosphonobutyric acid
Purity:	≥98% (HPLC)
Molecular Weight:	183.1

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Biological Activity for D-AP4

D-AP4 is a broad spectrum excitatory amino acid receptor antagonist. Also agonist at the quisqualate-sensitized AP6 site in hippocampus where it is less potent than L-AP4.

DL Mixture and L-isomer also available.

Technical Data for D-AP4

M. Wt	183.1
Formula	C₄H₁₀NO₅P
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	78739-01-2
PubChem ID	1550579
InChi Key	DDOQBQRIEWHWBT-GSVOUGTGSA-N
Smiles	N[C@@]([H])([C@](O)=O)CCP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for D-AP4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions for D-AP4

The following data is based on the product molecular weight 183.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.46 mL	27.31 mL	54.61 mL
5 mM	1.09 mL	5.46 mL	10.92 mL
10 mM	0.55 mL	2.73 mL	5.46 mL
50 mM	0.11 mL	0.55 mL	1.09 mL

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Reconstitution Calculator

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References for D-AP4

References are publications that support the biological activity of the product.

Schulte Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994 PMID: 7953634
Davies and Watkins Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 1982 PMID: 6145492
Evans The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 1982 PMID: 7042024

Citations for D-AP4 (3)

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Citations are publications that use Bio-Techne products. Selected citations for D-AP4 include:

France (2017) Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus. Neuropharmacology. 112:76
PMID: 27523302
Sexton and Gelder (2015) G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells. PLoS One. 10:e0128690
PMID: 26069965
Sexton et al. (2015) Type I intrinsically photosensitive retinal ganglion cells of early post-natal development correspond to the M4 subtype. Neural Dev. 10:17
PMID: 26091805

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Product Documents for D-AP4

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.