D-AP4
Tocris Bioscience, part of Bio-Techne | Catalog # 0102
Broad spectrum glutamatergic antagonist
Discontinued Product
0102 has been discontinued.
View all iGluR Antagonists products.
Key Product Details
Description
Broad spectrum glutamatergic antagonist
Product Description
D-AP4 is a broad spectrum excitatory amino acid receptor antagonist. Also agonist at the quisqualate-sensitized AP6 site in hippocampus where it is less potent than L-AP4.DL Mixture and L-isomer also available.
Product Specifications
Molecular Weight
183.10
Formula
C4H10NO5P
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
D-(-)-2-Amino-4-phosphonobutyric acid
CAS Number
78739-01-2
PubChem ID
1550579
InChI Key
DDOQBQRIEWHWBT-GSVOUGTGSA-N
SMILES
N[C@@]([H])([C@](O)=O)CCP(O)(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 100 |
Preparing Stock Solutions
for D-AP4
The following data is based on the product molecular weight 183.10
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.46 mL | 27.31 mL | 54.61 mL |
| 5 mM | 1.09 mL | 5.46 mL | 10.92 mL |
| 10 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 50 mM | 0.11 mL | 0.55 mL | 1.09 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Evans The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 1982 PMID: 7042024
- Schulte Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994 PMID: 7953634
- Davies and Watkins Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 1982 PMID: 6145492
Product Specific Notices for D-AP4
For research use only
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