D-AP4

Name: D-AP4
Brand: Tocris Bioscience
SKU: 0102

Tocris Bioscience, part of Bio-Techne | Catalog # 0102

Citations (1)

COA / SDS

Broad spectrum glutamatergic antagonist

Discontinued Product

0102 has been discontinued. View all iGluR Antagonists products.

Key Product Details

Description:	Broad spectrum glutamatergic antagonist
Chemical Name:	D-(-)-2-Amino-4-phosphonobutyric acid
Purity:	≥98% (HPLC)
Molecular Weight:	183.1

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Technical Data
Citations

Biological Activity for D-AP4

D-AP4 is a broad spectrum excitatory amino acid receptor antagonist. Also agonist at the quisqualate-sensitized AP6 site in hippocampus where it is less potent than L-AP4.

DL Mixture and L-isomer also available.

Technical Data for D-AP4

M. Wt	183.1
Formula	C₄H₁₀NO₅P
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	78739-01-2
PubChem ID	1550579
InChi Key	DDOQBQRIEWHWBT-GSVOUGTGSA-N
Smiles	N[C@@]([H])([C@](O)=O)CCP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for D-AP4

References are publications that support the biological activity of the product.

Evans The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 1982 PMID: 7042024
Schulte Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994 PMID: 7953634
Davies and Watkins Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 1982 PMID: 6145492

D-AP4

Tocris Bioscience, part of Bio-Techne | Catalog # 0102

Key Product Details

Biological Activity for D-AP4

Technical Data for D-AP4

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for D-AP4

Product Documents for D-AP4

COA

Certificate of Analysis

SDS

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