DL-AP4

Name: DL-AP4
Brand: Tocris Bioscience
SKU: 0101

Tocris Bioscience a Bio-Techne Brand

Catalog # 0101

Citations (6)

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Key Product Details

Description:	Broad spectrum glutamatergic antagonist
Chemical Name:	DL-2-Amino-4-phosphonobutyric acid
Purity:	≥98% (HPLC)
Molecular Weight:	183.1

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Biological Activity for DL-AP4

DL-AP4 is a broad spectrum EAA ligand.

D-isomer, L-isomer and Sodium Salt also available.

Technical Data for DL-AP4

M. Wt	183.1
Formula	C₄H₁₀NO₅P
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	6323-99-5
PubChem ID	2207
InChi Key	DDOQBQRIEWHWBT-UHFFFAOYSA-N
Smiles	O=C(C(N)CCP(O)(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DL-AP4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	9.15	50

Preparing Stock Solutions for DL-AP4

The following data is based on the product molecular weight 183.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	10.92 mL	54.61 mL	109.23 mL
2.5 mM	2.18 mL	10.92 mL	21.85 mL
5 mM	1.09 mL	5.46 mL	10.92 mL
25 mM	0.22 mL	1.09 mL	2.18 mL

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Reconstitution Calculator

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References for DL-AP4

References are publications that support the biological activity of the product.

Evans The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 1982 PMID: 7042024
Evans Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog. Br.J.Pharmacol. 1979 PMID: 316343

Citations for DL-AP4 (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for DL-AP4 include:

Ferlauto et al. (2018) Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis. Nat Commun. 9:992
PMID: 29520006
Chrispell et al. (2018) Grk1b and Grk7a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish. Invest Ophthalmol Vis Sci. 59:5116
PMID: 30372740
Vinberg et al. (2015) A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. Hum Mol Genet. 24:5915
PMID: 26246500
Schmidt and Kofuji (2011) Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse. J Comp Neurol. 519:1492
PMID: 21452206
Schmidt and Kofuji (2009) Functional and morphological differences among intrinsically photosensitive retinal ganglion cells. J Neurosci. 29:476
PMID: 19144848
Sekaran et al. (2005) Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina. Curr Biol. 15:1099
PMID: 15964274

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