Spatial Biology Insights | Bio-Techne Spatial

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Delivering Spatial Insights to Improve Lives

Bio-Techne Spatial is a global leader in spatial biology, delivering powerful transcriptomic, proteomic, and multiomic solutions to reveal ground-breaking discoveries, accelerate the development of next-generation therapeutics, and deliver life-changing diagnostics. Reveal new insights in cell phenotype and function with confidence using gold-standard RNAscope™ RNA ISH technology, proven Bio-Techne antibodies, and the COMET™ Spatial Biology Platform.

Many Spatial Questions. One Clear Answer.

Using RNAscope from Advanced Cell Diagnostics, accurately detect RNA expression at single-molecule sensitivity and subcellular resolution.
Visualize and quantify any RNA. Select from mRNAs, ncRNAs, siRNAs, ASO, splice variants, point mutations, reporters, transgenes and more.
Easily detect RNA and protein biomarkers on the same section for a comprehensive view of single-cell phenotype and function.
Characterize any organism or tissue with proven protocols.

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Hyperplex Workflow Without User Intervention.

Leveraging the COMET platform from Lunaphore, perform unmatched hyperplex throughput with walk-away automation
Use standard, off-the-shelf, label-free primary antibodies for rapid and flexible panel development. No conjugation or barcoding needed.
Maximize true reproducibility and tissue preservation.

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Customer Success Stories

Ruchi Komal PhD, Research Fellow
SLCR, National Institute of Mental Health, NIH

RNAscope spatial analysis greatly improves our research by offering high-resolution visualization of gene expression within the SCN... validating discoveries from single-cell data, identifying rare cell populations, and facilitating gene co-expression analysis in situ.

Dr Denis Schapiro
Heidelberg University Hospital

The Lunaphore COMET™ system has enabled us to perform highly-multiplexed imaging of entire cross sections of mouse hearts with sub-cellular resolution. The flexible panel design accelerated antibody validation and measurements so that we can already perform spatial analysis of the heart at scale.

Dr Cheryl Stoddart, Ekaterina Maidji

The identification and anatomic location of HIV-infected cells and the effects of tissue environment on virus replication and viral gene expression are all critical for evaluating the pathogenesis of HIV infection and for developing cure strategies to eliminate HIV reservoirs. RNAscope in situ hybridization (ISH) has enabled us to visualize and quantify HIV RNA with single-copy resolution. For work supported by a Federal Contract with NIAID, NIH, we are using this state-of-the-art ISH technology in combination with immunohistochemistry to characterize the tissue and cellular compartments where the virus resides in HIV-infected humanized mice.

Dr Rodrigo Romero
Memorial Sloan Kettering Cancer Center

The COMET allows our lab to perform any stain we want on the fly, while simultaneously creating a protocol that is easily transferrable to other members of the lab or community. Before, our research might have been limited by cost or time. With the COMET, we can identify markers that are present within established single cell datasets, and rapidly optimize a staining protocol to identify that specific marker across preclinical or clinical samples.

Featured Spatial Biology Products and Applications

Detection of cytokines, immune and tumor cells using an RNAscope RNA-protein multiomic panel of 4 marker proteins, CD4 (yellow), CD8 (white), PanCK (pink), FoxP3 (green), and 2 target RNA probes, IFNG (red), GZMB (turquoise) in human colon cancer tissue

Fully Automated Spatial Multiomics

Visualize cell phenotype and function with protease-free, same-slide codetection of protein and RNA.

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Profiling different cell types within the brain tumor microenvironment. Simultaneous detection of a panel of 3 marker proteins (CD8a, CD68, S100β) and 3 target RNA probes (CLDN5, CXCL10, TNFα) in brain tumor tissue.

Single Cell Validation

Visualize the spatial localization and activation states of novel cell subtypes.

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ACD HiPlex Pro on COMET image - melanoma

Validated Panels

Get inspired to build new assays with modular tools with the SPYRE™ Protein Detection Reagents, enabling the seamless transfer of immunofluorescence protocols into a COMET hyperplex assay to accelerate biomarker identification and validation.

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Intuitive Image Analysis

Simplify tissue analysis and evaluation with HORIZON™ Image Analysis Software tailored to COMET hyperplex immunofluorescence images.

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Reveal New Spatial Biology Insights in Health and Disease

Neuroscience

Spatially interrogate neuronal cell subtypes, central inflammatory responses, and networks of pain and addiction.

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Cancer

Uncover mechanisms underlying cancer initiation, progression, and therapeutic resistance.

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Inflammation

Quantify and characterize immune cell infiltration and activation including cytokine chemokine expression.

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Over 14K Spatial Biology Publications and Counting

Easily find peer-reviewed research articles for your gene or research area of interest. Discover real-world examples of how researchers are leveraging RNAscope and COMET to uncover new spatial insights.

Accelerate Therapeutics Development

Gene Therapy

Visualize AAV vector and ASO/siRNA biodistribution, cellular tropism, and transduction efficiency in spatial context.

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Cell Therapy

Quantify infiltration and cellular activation of engineered cells in cancer and diseased tissues.

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Spatial Biology

Delivering Spatial Insights to Improve Lives

Create Your Bio-Techne Account and Order RNAscope™ Assays & Probes Today!

Many Spatial Questions. One Clear Answer.

Hyperplex Workflow Without User Intervention.

Search RNAscope Target and Control Probes

Customer Success Stories