LDN 193189 in solution

Tocris Bioscience, part of Bio-Techne | Catalog # 8150

Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water
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Key Product Details

Description

Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water

View all BMP and Other Activin Receptor Inhibitors »

Product Description

LDN 193189 in solution is a convenient and ready-to-use 10 mM sterile-filtered solution of LDN 193189 pre-dissolved in water. A potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 nM and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Promotes neural induction of hPSCs in combination with SB 431542 (Cat. No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat. No. 1614), SU 5402 (Cat. No. 3300), CHIR 99021 (Cat. No. 4423) and DAPT (Cat. No. 2634).

Licensing Information

Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patents 8,507,501 and 9,045,484

Product Specifications

Molecular Weight

479.41

Formula

C25H22N6.2HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride

CAS Number

1435934-00-1

InChI Key

CMQXLLAILGGLRV-UHFFFAOYSA-N

SMILES

N1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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Background References

References are publications that support the biological activity of the product.

Product Documents for LDN 193189 in solution

Certificate of Analysis

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Product Specific Notices for LDN 193189 in solution

For research use only

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