SB 431542

Citations are publications that use Bio-Techne products. Selected citations for SB 431542 include:

• Rosebrock et al. (2022) Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells. Nat Cell Biol. 24:981
  PMID: 35697781
• Surendran et al. (2022) An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells STAR Protoc. 3:101803
  PMID: 36386870
• Kim et al. (2021) Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use. Cell Stem Cell. 28:343
  PMID: 33545081
• Piao et al. (2021) Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01 Cell Stem Cell. 28:217
  PMID: 33545080
• Yang et al. (2020) A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell. 27:125
  PMID: 32579880
• Yin et al. (2019) Chemical conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways. Stem Cell Reports. 12:488
  PMID: 30745031
• Yoon et al. (2019) Reliability of human cortical organoid generation. Nat Methods. 16:75
  PMID: 30573846
• Xiang et al. (2019) Long-term functional maintenance of primary human hepatocytes in vitro. Science. 364:399
  PMID: 31023926
• Paonessa et al. (2019) Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia. Cell Rep. 26:582
  PMID: 30650353
• Lang et al. (2019) Single-Cell Sequencing of iPSC-DA Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes. Cell Stem Cell. 24:93
  PMID: 30503143
• Varghese et al. (2019) Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches. Stem Cells Int. 2019:5968236
  PMID: 30805010
• Bise et al. (2019) Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart. NPJ Regen Med. 4:2
  PMID: 30701084
• Serrano et al. (2019) A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration. Stem Cells Dev. 28:81
  PMID: 30375284
• Aquino-Martínez et al. (2019) Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration. PLoS One. 14:e0210301
  PMID: 30608979
• Sharma et al. (2019) Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 39:212
  PMID: 30580570
• Easterbrook et al. (2019) Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo. Stem Cell Reports. 12:1056
  PMID: 30956115
• Haidar et al. (2019) Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies. Autophagy. 15:1051
  PMID: 30669930
• Nguyen et al. (2019) Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells. Stem Cells Int. 2019:3298432
  PMID: 31191670
• Gentsch et al. (2019) The Spatiotemporal Control of Zygotic Genome Activation. iScience. 16:485
  PMID: 31229896
• Gentsch et al. (2019) Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals. Nat Commun. 10:4269
  PMID: 31537794
• Yoshimatsu et al. (2019) A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology. PLoS One. 14:e0221164
  PMID: 31454364
• Yin et al. (2019) Neurons Derived from Human Induced Pluripotent Stem Cells Integrate into Rat Brain Circuits and Maintain Both Excitatory and Inhibitory Synaptic Activities. Eneuro. 6
  PMID: 31413152
• Canfield et al. (2019) An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons. Fluids Barriers CNS. 16:25
  PMID: 31387594
• Balbi et al. (2019) Supporting data on in vitro cardioprotective and proliferative paracrine effects by the human amniotic fluid stem cell secretome. Data Brief. 25:104324
  PMID: 31453298
• Caron et al. (2019) Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection. Stem Cell Res Ther. 10:221
  PMID: 31358055
• Garcia et al. (2019) Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Front Neurosci. 13:669
  PMID: 31316341
• Baror et al. (2019) Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors. Glia. 67:1374
  PMID: 30861188
• Montel-Hagen et al. (2019) Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 24:376
  PMID: 30661959
• Colunga et al. (2019) Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair. Cell Rep. 26:2566
  PMID: 30840882
• Frith and Tsakiridis (2019) Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate. Curr Protoc Stem Cell Biol. :e81
  PMID: 30688409
• Caires-J?nior (2018) Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun. 9(1):475
  PMID: 29396410
• Wang (2018) Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 24(5):647
  PMID: 29632371
• Magro-Lopez et al. (2018) Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids. Stem Cell Res.Ther.. 9:186
  PMID: 29996941
• Sommer et al. (2018) Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease. Cell Stem Cell.. 23:123
  PMID: 29979986
• Hsu et al. (2018) Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. Elife. 7
  PMID: 29469808
• Fr?hlich et al. (2018) Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain. Front Mol Neurosci. 11:81
  PMID: 29615866
• Yang et al. (2018) Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish. Sci Rep. 8:8495
  PMID: 29855567
• Medelnik et al. (2018) Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells. Stem Cell Reports. 10:1751
  PMID: 29779899
• Albers et al. (2018) TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation. Int J Stem Cells. 11:111
  PMID: 29699384
• Molina et al. (2018) MAPK and GSK3/�-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo. PLoS Genet. 14:e1007621
  PMID: 30222786
• Nehme et al. (2018) Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Rep. 23:2509
  PMID: 29791859
• Li et al. (2018) Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells. Stem Cell Reports. 11:998
  PMID: 30269954
• Sheng et al. (2018) A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. Nat Commun. 9:4047
  PMID: 30279449
• Bayo-Puxan et al. (2018) Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons. Sci Rep. 8:16644
  PMID: 30413728
• Raykhel et al. (2018) BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia. J Cell Sci. 131
  PMID: 29685894
• Subramanian et al. (2018) Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling. Elife. 7
  PMID: 30475205
• Smyth et al. (2018) TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus. Int J Parasitol. 48:379
  PMID: 29510118
• Bernard et al. (2018) Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation. J Biol Chem. 293:1218
  PMID: 29222329
• Wu et al. (2018) Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Cell. 172:423
  PMID: 29249360
• Tebbenkamp et al. (2018) The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development. Cell. 175:1088
  PMID: 30318146
• Mehta et al. (2018) Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation. Cell Rep. 25:1081
  PMID: 30355486
• Sloan et al. (2018) Generation and assembly of human brain region-specific three-dimensional cultures. Nat Protoc. 13:2062
  PMID: 30202107
• McCauley et al. (2018) Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 45:e51
  PMID: 30040246
• Noskovičová et al. (2018) Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 314:L695
  PMID: 29351434
• de la Mare (2017) Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model. BMC Cancer. 17(1):202
  PMID: 28302086
• Xi (2017) In Vivo Human Somitogenesis Guides Somite Development from hPSCs. Cell Rep. 18(6):1573
  PMID: 28178531
• Kotton et al. (2017) Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells. Cell Stem Cell.. 21:472
  PMID: 28965766
• Tchieu et al. (2017) A modular platform for differentiation of human PSCs into all major ectodermal lineages. Cell Stem Cell. 21:399
  PMID: 28886367
• Young (2017) The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1. Proc Natl Acad Sci U S A.. 114(28):E5599
  PMID: 28655839
• Offermann et al. (2017) MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling. Oncotarget. 8:7964
  PMID: 27974704
• Saini et al. (2017) Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration. Cell Stem Cell. 20:635
  PMID: 28132833
• Subramanian et al. (2017) Dynamic behaviour of human neuroepithelial cells in the developing forebrain. Nat Commun. 8:14167
  PMID: 28139695
• Kunnen et al. (2017) Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2. Cell Mol Life Sci. 74:2283
  PMID: 28168444
• Yang et al. (2017) Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma. Cell Mol Gastroenterol Hepatol. 3:484
  PMID: 28462385
• Christoforou et al. (2017) Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage. Sci Rep. 7:40285
  PMID: 28071742
• Ruetz et al. (2017) Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Cell Stem Cell. 21:791
  PMID: 29174331
• Park et al. (2017) Learning induces the translin/trax RNase complex to express activ. receptors for persistent memory. Elife. 6
  PMID: 28927503
• Yang et al. (2017) Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 169:243
  PMID: 28388409
• Guo et al. (2017) Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers. Biomaterials. 122:179
  PMID: 28129596
• Sampaziotis et al. (2017) Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc. 12:814
  PMID: 28333915
• McCauley et al. (2017) Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. Cell Stem Cell. 20:844
  PMID: 28366587
• Bershteyn et al. (2017) Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia. Cell Stem Cell. 20:435
  PMID: 28111201
• Song et al. (2017) Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation. Mol Cell. 67:148
  PMID: 28673540
• Bao et al. (2017) Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions. Nat Protoc. 12:1890
  PMID: 28817124
• Sloan et al. (2017) Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells. Neuron. 95:779
  PMID: 28817799
• Molina et al. (2017) p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation. Development. 144:2270
  PMID: 28507001
• Funaki et al. (2017) Chemotherapy enhances programmed cell death 1/ligand 1 expression via TGF-β induced epithelial mesenchymal transition in non-small cell lung cancer. Oncol Rep. 38:2277
  PMID: 28849209
• Major et al. (2017) Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells. Curr Protoc Stem Cell Biol. 39:1H.10.1
  PMID: 29081882
• Takata et al. (2017) Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function. Immunity. 47:183
  PMID: 28723550
• Charney et al. (2017) Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program. Dev Cell. 40:595
  PMID: 28325473
• Kapeli et al. (2016) Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses Nature Communications. 7:12143
  PMID: 27378374
• Mou et al. (2016) Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells Cell: Stem Cell. 19:217
  PMID: 27320041
• Vargel et al. (2016) Activation of the TGFβ pathway impairs endothelial to haematopoietic transition. Nat Protoc. 6:21518
  PMID: 26891705
• Huang et al. (2016) Generating trunk neural crest from human pluripotent stem cells. Sci Rep. 6:19727
  PMID: 26812940
• Morris et al. (2016) The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of AVNA/TGFβ and β1 integrin signalling. Mol Cell Biol. 6:19533
  PMID: 26782058
• Oenema et al. (2016) Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. Stem Cells. 8:e65580
  PMID: 23840342
• Marro et al. (2016) Collagen XII contributes to epicardial and connective tissues in the Zebrafish heart during ontogenesis and regeneration PLoS One. 11:e0165497
  PMID: 27783651
• Sulaiman et al. (2016) A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes PLoS Pathogens. 12:e1005991
  PMID: 27806135
• Moerkamp et al. (2016) Human fetal and adult epicardial-derived cells: a novel model to study their activation Stem Cell Research & Therapy. 7:174
  PMID: 27899163
• Locci et al. (2016) AVNA programs the differentiation of human TFH cells. Nat Immunol. 17:976
  PMID: 27376469
• Spender et al. (2016) Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells. Oncotarget. 7:81995
  PMID: 27835901
• Maturana et al. (2016) Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons. J Neuroinflammation. 13:295
  PMID: 27863501
• Manno et al. (2016) Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells. Cell. 167:566
  PMID: 27716510
• Topalovski et al. (2016) Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer. J Biol Chem. 291:22244
  PMID: 27531748
• Nott et al. (2016) Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. Nat Neurosci. 19:1497
  PMID: 27428650
• Buczek et al. (2016) Cytoplasmic PML promotes TGF-β-associated epithelial-mesenchymal transition and invasion in prostate cancer. Oncogene. 35:3465
  PMID: 26549027
• Zeltner et al. (2016) Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med. 22:1421
  PMID: 27841875
• Ghaedi and Niklason (2016) Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells. Methods Mol Biol. 2016;
  PMID: 27628133
• Genbacev et al. (2016) Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation. Hum Reprod. 31:1300
  PMID: 27083540
• Yan et al. (2015) Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. J Hepatol. 63:420
  PMID: 25828472
• Kumar et al. (2015) Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. Elife. 4
  PMID: 26554899
• Aspalter et al. (2015) Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nat Commun. 6:7264
  PMID: 26081042
• Pasca et al. (2015) Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat Methods. 12:671
  PMID: 26005811
• Oh et al. (2015) Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury. Stem Cell Res Ther. 6:125
  PMID: 26104416
• Sanders et al. (2015) SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts. PLoS One. 10:e0116995
  PMID: 25658089
• Piao et al. (2015) Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation. Cell Stem Cell. 16:198
  PMID: 25658373
• Woods et al. (2015) Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation. PLoS One. 10:e0123641
  PMID: 25955532
• Huang et al. (2015) The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Exp Cell Res. 10:413
  PMID: 25654758
• Bras et al. (2015) TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion. Mol Med. 330:29
  PMID: 25064463
• Chen et al. (2015) Pen. Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling. Brain. 21:276
  PMID: 25879629
• Iovino et al. (2015) Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations. Development. 138:3345
  PMID: 26220942
• Jönsson et al. (2015) Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor. Stem Cell Reports. 142:3166
  PMID: 26395143
• Agu et al. (2015) Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr. Exp Neurol. 5:660
  PMID: 26388286
• Saporta et al. (2015) Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties. Nat Commun. 263:190
  PMID: 25448007
• Sakaguchi et al. (2015) Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Mol Neurobiol. 6:8896
  PMID: 26573335
• Ooi et al. (2015) Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease. PLoS One. 52:1850
  PMID: 25398695
• Kawahara et al. (2015) TGF-β Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells. PeerJ. 10:e0125590
  PMID: 25970290
• Lages et al. (2015) Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells. J Reprod Dev. 3:e1486
  PMID: 26713239
• Honsho et al. (2015) Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells. BMC Cancer. 61:42626
  PMID: 25345855
• Wilson et al. (2015) The differential anti-tumour effects of Zol. acid in breast cancer - evidence for a role of the AVNsignaling pathway. Sci Rep. 15:55
  PMID: 25884855
• Caraci et al. (2015) A key role for TGF-β1 in hippocampal synaptic plasticity and memory. PLoS Comput Biol. 5:11252
  PMID: 26059637
• Ziv et al. (2015) Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development. Mol Biol Cell. 11:e1004453
  PMID: 26473351
• Niederst et al. (2015) Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Hum Mol Genet. 26:205
  PMID: 25392299
• Sposito et al. (2015) Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT. Stem Cell Reports. 24:5260
  PMID: 26136155
• Singh et al. (2015) Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency. Stem Cells Dev. 5:323
  PMID: 26278042
• Hu et al. (2015) Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling. J Virol. 24:2591
  PMID: 26218671
• Tabata et al. (2015) Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta. Sci Rep. 89:5134
  PMID: 25741001
• Ramnath et al. (2015) Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels. Evodevo. 5:16872
  PMID: 26607280
• Soukup et al. (2015) The Nodal signaling pathway controls left-right asymmetric development in amphioxus. J Clin Invest. 6:5
  PMID: 25954501
• Hadland et al. (2015) Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. Nat Cell Biol. 125:2032
  PMID: 25866967
• Cebola et al. (2015) TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Mol Cell Endocrinol. 17:615
  PMID: 25915126
• Martínez-Armenta et al. (2015) TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development. J Clin Invest. 400:129
  PMID: 25448845
• Li et al. (2015) MicroRNA-132 enhances transition from inflammation to proliferation during wound healing. Sci Rep. 125:3008
  PMID: 26121747
• Imaizumi et al. (2015) Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes. J Clin Invest. 5:1010
  PMID: 26549851
• Rempel et al. (2015) A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 89:1599
  PMID: 26272509
• Zhang et al. (2015) Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons. Cell Stem Cell. 17:735
  PMID: 26481520
• Ginsberg et al. (2015) Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state. Nat Protoc. 10:1975
  PMID: 26540589
• Aguila et al. (2014) Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for DA Neurons From Human Pluripotent Stem Cells. Stem Cells Transl Med. 3:1032
  PMID: 25024431
• Huang et al. (2014) Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 32:84
  PMID: 24291815
• Rosa et al. (2014) miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells. Dev Biol. 391:81
  PMID: 24709321
• Grunseich et al. (2014) Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients. Neurobiol Dis. 70:12
  PMID: 24925468
• Domev et al. (2014) Immunoevasive pericytes from human pluripotent stem cells preferentially modulate induction of allogeneic regulatory T cells. Stem Cells Transl Med. 3:1169
  PMID: 25205843
• Babu et al. (2014) TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer. 14:113
  PMID: 24555435
• Nishimura et al. (2014) Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells. PLoS One. 9:e91269
  PMID: 24651281
• Fang et al. (2014) Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells. J Pharm Sci Pharmacol. 1:175
  PMID: 25745638
• Wrighton et al. (2014) Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins. J Cell Sci. 111:18126
  PMID: 25422477
• Curado et al. (2014) ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells. Exp Neurol. 34:4389
  PMID: 25266657
• Wu et al. (2014) A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. Fibrogenesis Tissue Repair. 289:20193
  PMID: 24895131
• Soares et al. (2014) Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions. Cell Stem Cell. 173:53
  PMID: 24440272
• Dai et al. (2014) Combining TGF-β signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes. PLoS One. 4:7323
  PMID: 25471520
• Magaña et al. (2014) Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation. Dev Biol. 387:15
  PMID: 24445281
• O'Reilly et al. (2014) Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein. J Biol Chem. 289:9952
  PMID: 24550394
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• Luo and Su (2012) Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva. PLoS Biol. 10:e1001402
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• Tan et al. (2011) Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4. Nat Cell Biol. 6:e17124
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• Chen et al. (2011) Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism. PLoS One. 4:9
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• Xi et al. (2011) A poised chromatin platform for TGF-β access to master regulators. Biochem Biophys Res Commun. 147:1511
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• Grocott et al. (2011) Neural crest cells organize the eye via TGF-β and canonical Wnt signalling. Stem Cell Reports. 2:265
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• Seibler et al. (2011) Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells. Shock. 31:5970
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• Duan et al. (2011) Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells. J Clin Cell Immunol. 36:54
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• Xie et al. (2011) Transforming Growth Factor-β1 Antagonizes Interleukin-5 Pro-Survival Signaling by Activating Calpain-1 in Primary Human Eosinophils. Proc Natl Acad Sci U S A. Suppl 1
  PMID: 24244891
• Holley et al. (2011) Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble Hep. and heparan sulfate saccharides. J Biol Chem. 286:6241
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• Kurita and Wada (2011) Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-beta signalling. Biol Lett. 7:759
  PMID: 21525052
• Dangi-Garimella et al. (2011) Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression. Oncogene. 30:1002
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• Fong et al. (2010) Tumor-supportive and osteoclastogenic changes induced by breast cancer-derived factors are reversed by inhibition of {gamma}-secretase. J Biol Chem. 285:31427
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• Moyano et al. (2010) Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. Mol Biol Cell. 21:3654
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• Ishida et al. (2010) Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish. Dev Biol. 340:468
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• Hannigan et al. (2010) Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter. J Clin Invest. 120:2842
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• Ham et al. (2010) PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins. J Cell Mol Med. 14:1747
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• Redondo et al. (2010) Role of TGF-β1 and MAP kinases in the antiproliferative effect of aspirin in human vascular smooth muscle cells. PLoS One. 5:e9800
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• Effective inhibition of TGFb family receptors

  Name: Paul Humphreys
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: hESCs/Tc28a2s
  I have used SB431542 for both selective inhibition of TGFb family receptors in TGFb activity assays and to drive differentiation of pluripotent stem cells towards mesodermal tissues.Concentration: 1nM working
  If possible perform titration of SB431542 with TGFb signalling output depending upon cell type or application.
  

• Differentiation to cortical neurons

  Name: Julieta O'Flaherty
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: Induced pluripotent stem cells
  I routinely use this product to differentiate human induced pluripotent stem cells into cortical neurons. I use it at 10uM. Once reconstituted, I would only store it for a maximum of one month in -80C
  Keep at -80C for a maximum of 1 month
  

• iPSC differentiation

  Name: Stephanie Hsiao
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: iPSC
  Differentiation of human iPSCs into hematopoietic progenitor cells
  iPSC culture medium with 4 uM SB431542
  

• For hPSC culture

  Name: Anonymous
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: Human PSC
  For hPSC culture, final concentration 10 μM.
  Make 100µl aliquots and keep them at −20 °C for up to 6 months.
  PMID: PMID, 27841875
  

• Dífferentiation of iPSC into neural progentor cells

  Name: Vladimir Milenkovic
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: iPSC
  Human induced pluripotent stem cells (iPSCs) were differentiated into neural progenitor cells (NPCs) as described in Chambers et al. 2009 (PMID: 19252484.) SB431542 was used at 20uM. Differentiated NPCs were then immunostained using PAX6 monoclonal Ab, and we had over 80% of PAX6 positive cells.
  

• endothelial differentiation

  Name: Anonymous
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: stem cells differentiated endothelial cells
  Stems cells undergoing differentiation to endothelial cells utilize addition of SB 431542. FLK+ve cells cultured with SB 431542 revealed colonies of endothelial cells (arrows)
  

• Works great.

  Name: Anonymous
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: Induced pluripotent stem cells
  I used this product for differentiation of iPSCs into dopaminergic neurons according to the protocol published in Kriks et al, 2011.I used the concentration 10uM and it works really well.

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