Key Product Details
Description: | Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7 |
Chemical Name: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 384.39 |
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Citations for SB 431542 (261)
Citations are publications that use Bio-Techne products. Selected citations for SB 431542 include:
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Rosebrock et al.
(2022)
Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells.
Nat Cell Biol.
24:981
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Surendran et al.
(2022)
An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells
STAR Protoc.
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Kim et al.
(2021)
Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use.
Cell Stem Cell.
28:343
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Piao et al.
(2021)
Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01
Cell Stem Cell.
28:217
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Yang et al.
(2020)
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Cell Stem Cell.
27:125
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Yin et al.
(2019)
Chemical conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways.
Stem Cell Reports.
12:488
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Yoon et al.
(2019)
Reliability of human cortical organoid generation.
Nat Methods.
16:75
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Xiang et al.
(2019)
Long-term functional maintenance of primary human hepatocytes in vitro.
Science.
364:399
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Paonessa et al.
(2019)
Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
Cell Rep.
26:582
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Lang et al.
(2019)
Single-Cell Sequencing of iPSC-DA Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
Cell Stem Cell.
24:93
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Varghese et al.
(2019)
Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches.
Stem Cells Int.
2019:5968236
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Bise et al.
(2019)
Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart.
NPJ Regen Med.
4:2
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Serrano et al.
(2019)
A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration.
Stem Cells Dev.
28:81
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Aquino-Martínez et al.
(2019)
Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration.
PLoS One.
14:e0210301
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Sharma et al.
(2019)
Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm.
Arterioscler Thromb Vasc Biol.
39:212
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Easterbrook et al.
(2019)
Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo.
Stem Cell Reports.
12:1056
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Haidar et al.
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Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.
Autophagy.
15:1051
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Nguyen et al.
(2019)
Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.
Stem Cells Int.
2019:3298432
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Gentsch et al.
(2019)
The Spatiotemporal Control of Zygotic Genome Activation.
iScience.
16:485
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Gentsch et al.
(2019)
Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals.
Nat Commun.
10:4269
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Yoshimatsu et al.
(2019)
A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology.
PLoS One.
14:e0221164
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Yin et al.
(2019)
Neurons Derived from Human Induced Pluripotent Stem Cells Integrate into Rat Brain Circuits and Maintain Both Excitatory and Inhibitory Synaptic Activities.
Eneuro.
6
PMID: 31413152 -
Canfield et al.
(2019)
An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons.
Fluids Barriers CNS.
16:25
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Balbi et al.
(2019)
Supporting data on in vitro cardioprotective and proliferative paracrine effects by the human amniotic fluid stem cell secretome.
Data Brief.
25:104324
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Caron et al.
(2019)
Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.
Stem Cell Res Ther.
10:221
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Garcia et al.
(2019)
Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
Front Neurosci.
13:669
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Baror et al.
(2019)
Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors.
Glia.
67:1374
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Montel-Hagen et al.
(2019)
Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells.
Cell Stem Cell.
24:376
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Colunga et al.
(2019)
Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.
Cell Rep.
26:2566
PMID: 30840882 -
Frith and Tsakiridis
(2019)
Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate.
Curr Protoc Stem Cell Biol.
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Caires-J?nior
(2018)
Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
Nat Commun.
9(1):475
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Wang
(2018)
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
Nat Med.
24(5):647
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Magro-Lopez et al.
(2018)
Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids.
Stem Cell Res.Ther..
9:186
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Sommer et al.
(2018)
Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
Cell Stem Cell..
23:123
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Hsu et al.
(2018)
Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria.
Elife.
7
PMID: 29469808 -
Fr?hlich et al.
(2018)
Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain.
Front Mol Neurosci.
11:81
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Yang et al.
(2018)
Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish.
Sci Rep.
8:8495
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Medelnik et al.
(2018)
Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.
Stem Cell Reports.
10:1751
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Albers et al.
(2018)
TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation.
Int J Stem Cells.
11:111
PMID: 29699384 -
Molina et al.
(2018)
MAPK and GSK3/�-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo.
PLoS Genet.
14:e1007621
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Nehme et al.
(2018)
Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.
Cell Rep.
23:2509
PMID: 29791859 -
Li et al.
(2018)
Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells.
Stem Cell Reports.
11:998
PMID: 30269954 -
Sheng et al.
(2018)
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
Nat Commun.
9:4047
PMID: 30279449 -
Bayo-Puxan et al.
(2018)
Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.
Sci Rep.
8:16644
PMID: 30413728 -
Raykhel et al.
(2018)
BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia.
J Cell Sci.
131
PMID: 29685894 -
Subramanian et al.
(2018)
Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling.
Elife.
7
PMID: 30475205 -
Smyth et al.
(2018)
TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus.
Int J Parasitol.
48:379
PMID: 29510118 -
Bernard et al.
(2018)
Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.
J Biol Chem.
293:1218
PMID: 29222329 -
Wu et al.
(2018)
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell.
172:423
PMID: 29249360 -
Tebbenkamp et al.
(2018)
The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development.
Cell.
175:1088
PMID: 30318146 -
Mehta et al.
(2018)
Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation.
Cell Rep.
25:1081
PMID: 30355486 -
Sloan et al.
(2018)
Generation and assembly of human brain region-specific three-dimensional cultures.
Nat Protoc.
13:2062
PMID: 30202107 -
McCauley et al.
(2018)
Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells.
Curr Protoc Stem Cell Biol.
45:e51
PMID: 30040246 -
Noskovičová et al.
(2018)
Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.
Am J Physiol Lung Cell Mol Physiol.
314:L695
PMID: 29351434 -
de la Mare
(2017)
Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model.
BMC Cancer.
17(1):202
PMID: 28302086 -
Xi
(2017)
In Vivo Human Somitogenesis Guides Somite Development from hPSCs.
Cell Rep.
18(6):1573
PMID: 28178531 -
Kotton et al.
(2017)
Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells.
Cell Stem Cell..
21:472
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Tchieu et al.
(2017)
A modular platform for differentiation of human PSCs into all major ectodermal lineages.
Cell Stem Cell.
21:399
PMID: 28886367 -
Young
(2017)
The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
Proc Natl Acad Sci U S A..
114(28):E5599
PMID: 28655839 -
Offermann et al.
(2017)
MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.
Oncotarget.
8:7964
PMID: 27974704 -
Saini et al.
(2017)
Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration.
Cell Stem Cell.
20:635
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Subramanian et al.
(2017)
Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
Nat Commun.
8:14167
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Kunnen et al.
(2017)
Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
Cell Mol Life Sci.
74:2283
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Yang et al.
(2017)
Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma.
Cell Mol Gastroenterol Hepatol.
3:484
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Christoforou et al.
(2017)
Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage.
Sci Rep.
7:40285
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Ruetz et al.
(2017)
Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.
Cell Stem Cell.
21:791
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Park et al.
(2017)
Learning induces the translin/trax RNase complex to express activ. receptors for persistent memory.
Elife.
6
PMID: 28927503 -
Yang et al.
(2017)
Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
Cell.
169:243
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Guo et al.
(2017)
Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers.
Biomaterials.
122:179
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Sampaziotis et al.
(2017)
Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.
Nat Protoc.
12:814
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McCauley et al.
(2017)
Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.
Cell Stem Cell.
20:844
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Bershteyn et al.
(2017)
Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia.
Cell Stem Cell.
20:435
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Song et al.
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Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation.
Mol Cell.
67:148
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Bao et al.
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Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions.
Nat Protoc.
12:1890
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Sloan et al.
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Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
Neuron.
95:779
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Molina et al.
(2017)
p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation.
Development.
144:2270
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Funaki et al.
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Chemotherapy enhances programmed cell death 1/ligand 1 expression via TGF-β induced epithelial mesenchymal transition in non-small cell lung cancer.
Oncol Rep.
38:2277
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Major et al.
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Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells.
Curr Protoc Stem Cell Biol.
39:1H.10.1
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Takata et al.
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Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.
Immunity.
47:183
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Charney et al.
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Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program.
Dev Cell.
40:595
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Kapeli et al.
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Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
Nature Communications.
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Mou et al.
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Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
Cell: Stem Cell.
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Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.
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Generating trunk neural crest from human pluripotent stem cells.
Sci Rep.
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The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of AVNA/TGFβ and β1 integrin signalling.
Mol Cell Biol.
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Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
Stem Cells.
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Marro et al.
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Collagen XII contributes to epicardial and connective tissues in the Zebrafish heart during ontogenesis and regeneration
PLoS One.
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A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes
PLoS Pathogens.
12:e1005991
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Moerkamp et al.
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Human fetal and adult epicardial-derived cells: a novel model to study their activation
Stem Cell Research & Therapy.
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AVNA programs the differentiation of human TFH cells.
Nat Immunol.
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Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.
Oncotarget.
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Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.
J Neuroinflammation.
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Manno et al.
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Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.
Cell.
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Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.
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Oncogene.
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Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells.
Methods Mol Biol.
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Hum Reprod.
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Elife.
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Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
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Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
Nat Methods.
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Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury.
Stem Cell Res Ther.
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SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts.
PLoS One.
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Piao et al.
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Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
Cell Stem Cell.
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Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation.
PLoS One.
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The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
Exp Cell Res.
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TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
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Pen. Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling.
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Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
Development.
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Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.
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Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.
Exp Neurol.
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Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties.
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Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
Mol Neurobiol.
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Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.
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TGF-β Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells.
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Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells.
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Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells.
BMC Cancer.
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The differential anti-tumour effects of Zol. acid in breast cancer - evidence for a role of the AVNsignaling pathway.
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A key role for TGF-β1 in hippocampal synaptic plasticity and memory.
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Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development.
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Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
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Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency.
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Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling.
J Virol.
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Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
Sci Rep.
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Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.
Evodevo.
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The Nodal signaling pathway controls left-right asymmetric development in amphioxus.
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Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
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TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
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MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
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Customer Reviews for SB 431542 (7)
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Species: HumanAssay Type: In VitroCell Line/Tissue: hESCs/Tc28a2sI have used SB431542 for both selective inhibition of TGFb family receptors in TGFb activity assays and to drive differentiation of pluripotent stem cells towards mesodermal tissues.Concentration: 1nM workingIf possible perform titration of SB431542 with TGFb signalling output depending upon cell type or application.
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Species: HumanAssay Type: In VitroCell Line/Tissue: Induced pluripotent stem cellsI routinely use this product to differentiate human induced pluripotent stem cells into cortical neurons. I use it at 10uM. Once reconstituted, I would only store it for a maximum of one month in -80CKeep at -80C for a maximum of 1 month
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Species: HumanAssay Type: In VitroCell Line/Tissue: iPSCDifferentiation of human iPSCs into hematopoietic progenitor cellsiPSC culture medium with 4 uM SB431542
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Species: HumanAssay Type: In VitroCell Line/Tissue: Human PSCFor hPSC culture, final concentration 10 μM.Make 100µl aliquots and keep them at −20 °C for up to 6 months.
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Species: HumanAssay Type: In VitroCell Line/Tissue: iPSCHuman induced pluripotent stem cells (iPSCs) were differentiated into neural progenitor cells (NPCs) as described in Chambers et al. 2009 (PMID: 19252484.) SB431542 was used at 20uM. Differentiated NPCs were then immunostained using PAX6 monoclonal Ab, and we had over 80% of PAX6 positive cells.
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Species: HumanAssay Type: In VitroCell Line/Tissue: stem cells differentiated endothelial cellsStems cells undergoing differentiation to endothelial cells utilize addition of SB 431542. FLK+ve cells cultured with SB 431542 revealed colonies of endothelial cells (arrows)
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Species: HumanAssay Type: In VitroCell Line/Tissue: Induced pluripotent stem cellsI used this product for differentiation of iPSCs into dopaminergic neurons according to the protocol published in Kriks et al, 2011.I used the concentration 10uM and it works really well.
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