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TGF-beta Receptor Inhibitors Small Molecule
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Key Product Details

Description: Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity: ≥99% (HPLC)
Molecular Weight: 384.39

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Citations (259)

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Customer Reviews (10)

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  • Effective inhibition of TGFb family receptors
    Name: Paul Humphreys
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: hESCs/Tc28a2s
    I have used SB431542 for both selective inhibition of TGFb family receptors in TGFb activity assays and to drive differentiation of pluripotent stem cells towards mesodermal tissues.Concentration: 1nM working
    If possible perform titration of SB431542 with TGFb signalling output depending upon cell type or application.
    SB 431542 Serum 1614
  • Differentiation to cortical neurons
    Name: Julieta O'Flaherty
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Induced pluripotent stem cells
    I routinely use this product to differentiate human induced pluripotent stem cells into cortical neurons. I use it at 10uM. Once reconstituted, I would only store it for a maximum of one month in -80C
    Keep at -80C for a maximum of 1 month
    SB 431542 Serum 1614
  • Inhibition of pSmad 2/3 in a human epithelial cell line
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: A549
    Tested a human lung epithelial cell line pretreated with SB431542 at either 10, 1 or 0.1uM for 30 min and then added TGFb1 at 5ng/ml in two different matrices. Incubated 24hr and then lysed cells to look at pSmad 2/3 levels by immunoassay
  • iPSC differentiation
    Name: Stephanie Hsiao
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: iPSC
    Differentiation of human iPSCs into hematopoietic progenitor cells
    iPSC culture medium with 4 uM SB431542
    SB 431542 Serum 1614
  • For hPSC culture
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human PSC
    For hPSC culture, final concentration 10 μM.
    Make 100µl aliquots and keep them at −20 °C for up to 6 months.
    SB 431542 Serum 1614
  • 3D cultures
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: iPS cells
    Worked consistently in generation of cerebral organoids from human iPS cells
  • Dífferentiation of iPSC into neural progentor cells
    Name: Vladimir Milenkovic
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: iPSC
    Human induced pluripotent stem cells (iPSCs) were differentiated into neural progenitor cells (NPCs) as described in Chambers et al. 2009 (PMID: 19252484.) SB431542 was used at 20uM. Differentiated NPCs were then immunostained using PAX6 monoclonal Ab, and we had over 80% of PAX6 positive cells.
    SB 431542 Serum 1614
  • Works really well as a TGF-beta receptor Inhibitor
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Breast Cancer Cells
    I used it as a TGF-beta receptor Inhibitor in Breast cancer Cells to study the impact of blocking TGF-beta pathway on EMT. I used the concentration 5uM and it works really well.
  • endothelial differentiation
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: stem cells differentiated endothelial cells
    Stems cells undergoing differentiation to endothelial cells utilize addition of SB 431542. FLK+ve cells cultured with SB 431542 revealed colonies of endothelial cells (arrows)
    SB 431542 Serum 1614
  • Works great.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Induced pluripotent stem cells
    I used this product for differentiation of iPSCs into dopaminergic neurons according to the protocol published in Kriks et al, 2011.I used the concentration 10uM and it works really well.

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