SB 431542

Citations are publications that use Bio-Techne products. Selected citations for SB 431542 include:

• piao et al. (2021) Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01 Cell Stem Cell. 28:217
  PMID: 33545080
• Kim et al. (2021) Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use. Cell Stem Cell. 28:343
  PMID: 33545081
• Yang et al. (2020) A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell. 27:125
  PMID: 32579880
• Aquino-Martínez et al. (2019) Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration. PLoS One. 14:e0210301
  PMID: 30608979
• Yoshimatsu et al. (2019) A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology. PLoS One. 14:e0221164
  PMID: 31454364
• Gentsch et al. (2019) Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals. Nat Commun. 10:4269
  PMID: 31537794
• Gentsch et al. (2019) The Spatiotemporal Control of Zygotic Genome Activation. iScience. 16:485
  PMID: 31229896
• Nguyen et al. (2019) Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells. Stem Cells Int. 2019:3298432
  PMID: 31191670
• Easterbrook et al. (2019) Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo. Stem Cell Reports. 12:1056
  PMID: 30956115
• Sharma et al. (2019) Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 39:212
  PMID: 30580570
• Bise et al. (2019) Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart. NPJ Regen Med. 4:2
  PMID: 30701084
• Serrano et al. (2019) A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration. Stem Cells Dev. 28:81
  PMID: 30375284
• Canfield et al. (2019) An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons. Fluids Barriers CNS. 16:25
  PMID: 31387594
• Varghese et al. (2019) Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches. Stem Cells Int. 2019:5968236
  PMID: 30805010
• Lang et al. (2019) Single-Cell Sequencing of iPSC-DA Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes. Cell Stem Cell. 24:93
  PMID: 30503143
• Paonessa et al. (2019) Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia. Cell Rep. 26:582
  PMID: 30650353
• Yin et al. (2019) Chemical conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways. Stem Cell Reports. 12:488
  PMID: 30745031
• Yoon et al. (2019) Reliability of human cortical organoid generation. Nat Methods. 16:75
  PMID: 30573846
• Yin et al. (2019) Neurons Derived from Human Induced Pluripotent Stem Cells Integrate into Rat Brain Circuits and Maintain Both Excitatory and Inhibitory Synaptic Activities. Eneuro. 6
  PMID: 31413152
• Haidar et al. (2019) Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies. Autophagy. 15:1051
  PMID: 30669930
• Balbi et al. (2019) Supporting data on in vitro cardioprotective and proliferative paracrine effects by the human amniotic fluid stem cell secretome. Data Brief. 25:104324
  PMID: 31453298
• Baror et al. (2019) Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors. Glia. 67:1374
  PMID: 30861188
• Frith and Tsakiridis (2019) Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate. Curr Protoc Stem Cell Biol. :e81
  PMID: 30688409
• Colunga et al. (2019) Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair. Cell Rep. 26:2566
  PMID: 30840882
• Montel-Hagen et al. (2019) Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 24:376
  PMID: 30661959
• Xiang et al. (2019) Long-term functional maintenance of primary human hepatocytes in vitro. Science. 364:399
  PMID: 31023926
• Garcia et al. (2019) Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Front Neurosci. 13:669
  PMID: 31316341
• Caron et al. (2019) Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection. Stem Cell Res Ther. 10:221
  PMID: 31358055
• Medelnik et al. (2018) Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells. Stem Cell Reports. 10:1751
  PMID: 29779899
• Nehme et al. (2018) Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Rep. 23:2509
  PMID: 29791859
• Sommer et al. (2018) Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease. Cell Stem Cell.. 23:123
  PMID: 29979986
• Magro-Lopez et al. (2018) Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids. Stem Cell Res.Ther.. 9:186
  PMID: 29996941
• Wang (2018) Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 24(5):647
  PMID: 29632371
• Li et al. (2018) Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells. Stem Cell Reports. 11:998
  PMID: 30269954
• Sheng et al. (2018) A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. Nat Commun. 9:4047
  PMID: 30279449
• Bayo-Puxan et al. (2018) Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons. Sci Rep. 8:16644
  PMID: 30413728
• Noskovičová et al. (2018) Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 314:L695
  PMID: 29351434
• McCauley et al. (2018) Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 45:e51
  PMID: 30040246
• Sloan et al. (2018) Generation and assembly of human brain region-specific three-dimensional cultures. Nat Protoc. 13:2062
  PMID: 30202107
• Mehta et al. (2018) Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation. Cell Rep. 25:1081
  PMID: 30355486
• Tebbenkamp et al. (2018) The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development. Cell. 175:1088
  PMID: 30318146
• Albers et al. (2018) TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation. Int J Stem Cells. 11:111
  PMID: 29699384
• Hsu et al. (2018) Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. Elife. 7
  PMID: 29469808
• Molina et al. (2018) MAPK and GSK3/�-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo. PLoS Genet. 14:e1007621
  PMID: 30222786
• Fr?hlich et al. (2018) Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain. Front Mol Neurosci. 11:81
  PMID: 29615866
• Caires-J?nior (2018) Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun. 9(1):475
  PMID: 29396410
• Wu et al. (2018) Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Cell. 172:423
  PMID: 29249360
• Bernard et al. (2018) Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation. J Biol Chem. 293:1218
  PMID: 29222329
• Smyth et al. (2018) TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus. Int J Parasitol. 48:379
  PMID: 29510118
• Subramanian et al. (2018) Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling. Elife. 7
  PMID: 30475205
• Yang et al. (2018) Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish. Sci Rep. 8:8495
  PMID: 29855567
• Raykhel et al. (2018) BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia. J Cell Sci. 131
  PMID: 29685894
• Park et al. (2017) Learning induces the translin/trax RNase complex to express activ. receptors for persistent memory. Elife. 6
  PMID: 28927503
• Yang et al. (2017) Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 169:243
  PMID: 28388409
• Sampaziotis et al. (2017) Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc. 12:814
  PMID: 28333915
• Guo et al. (2017) Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers. Biomaterials. 122:179
  PMID: 28129596
• McCauley et al. (2017) Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. Cell Stem Cell. 20:844
  PMID: 28366587
• Yang et al. (2017) Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma. Cell Mol Gastroenterol Hepatol. 3:484
  PMID: 28462385
• Ruetz et al. (2017) Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Cell Stem Cell. 21:791
  PMID: 29174331
• Christoforou et al. (2017) Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage. Sci Rep. 7:40285
  PMID: 28071742
• de la Mare (2017) Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model. BMC Cancer. 17(1):202
  PMID: 28302086
• Xi (2017) In Vivo Human Somitogenesis Guides Somite Development from hPSCs. Cell Rep. 18(6):1573
  PMID: 28178531
• Kotton et al. (2017) Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells. Cell Stem Cell.. 21:472
  PMID: 28965766
• Tchieu et al. (2017) A modular platform for differentiation of human PSCs into all major ectodermal lineages. Cell Stem Cell. 21:399
  PMID: 28886367
• Young (2017) The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1. Proc Natl Acad Sci U S A.. 114(28):E5599
  PMID: 28655839
• Kunnen et al. (2017) Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2. Cell Mol Life Sci. 74:2283
  PMID: 28168444
• Subramanian et al. (2017) Dynamic behaviour of human neuroepithelial cells in the developing forebrain. Nat Commun. 8:14167
  PMID: 28139695
• Saini et al. (2017) Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration. Cell Stem Cell. 20:635
  PMID: 28132833
• Bershteyn et al. (2017) Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia. Cell Stem Cell. 20:435
  PMID: 28111201
• Offermann et al. (2017) MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling. Oncotarget. 8:7964
  PMID: 27974704
• Sloan et al. (2017) Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells. Neuron. 95:779
  PMID: 28817799
• Charney et al. (2017) Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program. Dev Cell. 40:595
  PMID: 28325473
• Bao et al. (2017) Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions. Nat Protoc. 12:1890
  PMID: 28817124
• Song et al. (2017) Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation. Mol Cell. 67:148
  PMID: 28673540
• Molina et al. (2017) p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation. Development. 144:2270
  PMID: 28507001
• Funaki et al. (2017) Chemotherapy enhances programmed cell death 1/ligand 1 expression via TGF-β induced epithelial mesenchymal transition in non-small cell lung cancer. Oncol Rep. 38:2277
  PMID: 28849209
• Takata et al. (2017) Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function. Immunity. 47:183
  PMID: 28723550
• Major et al. (2017) Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells. Curr Protoc Stem Cell Biol. 39:1H.10.1
  PMID: 29081882
• Ghaedi and Niklason (2016) Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells. Methods Mol Biol. 2016;
  PMID: 27628133
• Mou et al. (2016) Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells Cell: Stem Cell. 19:217
  PMID: 27320041
• Zeltner et al. (2016) Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med. 22:1421
  PMID: 27841875
• Maturana et al. (2016) Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons. J Neuroinflammation. 13:295
  PMID: 27863501
• Morris et al. (2016) The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of AVNA/TGFβ and β1 integrin signalling. Mol Cell Biol. 6:19533
  PMID: 26782058
• Huang et al. (2016) Generating trunk neural crest from human pluripotent stem cells. Sci Rep. 6:19727
  PMID: 26812940
• Vargel et al. (2016) Activation of the TGFβ pathway impairs endothelial to haematopoietic transition. Nat Protoc. 6:21518
  PMID: 26891705
• Spender et al. (2016) Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells. Oncotarget. 7:81995
  PMID: 27835901
• Oenema et al. (2016) Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. Stem Cells. 8:e65580
  PMID: 23840342
• Locci et al. (2016) AVNA programs the differentiation of human TFH cells. Nat Immunol. 17:976
  PMID: 27376469
• Genbacev et al. (2016) Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation. Hum Reprod. 31:1300
  PMID: 27083540
• Nott et al. (2016) Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. Nat Neurosci. 19:1497
  PMID: 27428650
• Buczek et al. (2016) Cytoplasmic PML promotes TGF-β-associated epithelial-mesenchymal transition and invasion in prostate cancer. Oncogene. 35:3465
  PMID: 26549027
• Topalovski et al. (2016) Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer. J Biol Chem. 291:22244
  PMID: 27531748
• Manno et al. (2016) Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells. Cell. 167:566
  PMID: 27716510
• Marro et al. (2016) Collagen XII contributes to epicardial and connective tissues in the Zebrafish heart during ontogenesis and regeneration PLoS One. 11:e0165497
  PMID: 27783651
• Sulaiman et al. (2016) A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes PLoS Pathogens. 12:e1005991
  PMID: 27806135
• Moerkamp et al. (2016) Human fetal and adult epicardial-derived cells: a novel model to study their activation Stem Cell Research & Therapy. 7:174
  PMID: 27899163
• Kapeli et al. (2016) Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses Nature Communications. 7:12143
  PMID: 27378374
• Woods et al. (2015) Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation. PLoS One. 10:e0123641
  PMID: 25955532
• Pasca et al. (2015) Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat Methods. 12:671
  PMID: 26005811
• Imaizumi et al. (2015) Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes. J Clin Invest. 5:1010
  PMID: 26549851
• Iovino et al. (2015) Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations. Development. 138:3345
  PMID: 26220942
• Sanders et al. (2015) SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts. PLoS One. 10:e0116995
  PMID: 25658089
• Oh et al. (2015) Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury. Stem Cell Res Ther. 6:125
  PMID: 26104416
• Kumar et al. (2015) Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. Elife. 4
  PMID: 26554899
• Ginsberg et al. (2015) Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state. Nat Protoc. 10:1975
  PMID: 26540589
• Yan et al. (2015) Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. J Hepatol. 63:420
  PMID: 25828472
• Aspalter et al. (2015) Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nat Commun. 6:7264
  PMID: 26081042
• Zhang et al. (2015) Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons. Cell Stem Cell. 17:735
  PMID: 26481520
• Chen et al. (2015) Pen. Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling. Brain. 21:276
  PMID: 25879629
• Piao et al. (2015) Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation. Cell Stem Cell. 16:198
  PMID: 25658373
• Lages et al. (2015) Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells. J Reprod Dev. 3:e1486
  PMID: 26713239
• Honsho et al. (2015) Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells. BMC Cancer. 61:42626
  PMID: 25345855
• Hu et al. (2015) Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling. J Virol. 24:2591
  PMID: 26218671
• Sposito et al. (2015) Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT. Stem Cell Reports. 24:5260
  PMID: 26136155
• Niederst et al. (2015) Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Hum Mol Genet. 26:205
  PMID: 25392299
• Ziv et al. (2015) Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development. Mol Biol Cell. 11:e1004453
  PMID: 26473351
• Caraci et al. (2015) A key role for TGF-β1 in hippocampal synaptic plasticity and memory. PLoS Comput Biol. 5:11252
  PMID: 26059637
• Wilson et al. (2015) The differential anti-tumour effects of Zol. acid in breast cancer - evidence for a role of the AVNsignaling pathway. Sci Rep. 15:55
  PMID: 25884855
• Rempel et al. (2015) A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 89:1599
  PMID: 26272509
• Ramnath et al. (2015) Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels. Evodevo. 5:16872
  PMID: 26607280
• Kawahara et al. (2015) TGF-β Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells. PeerJ. 10:e0125590
  PMID: 25970290
• Ooi et al. (2015) Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease. PLoS One. 52:1850
  PMID: 25398695
• Sakaguchi et al. (2015) Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Mol Neurobiol. 6:8896
  PMID: 26573335
• Saporta et al. (2015) Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties. Nat Commun. 263:190
  PMID: 25448007
• Agu et al. (2015) Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr. Exp Neurol. 5:660
  PMID: 26388286
• Jönsson et al. (2015) Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor. Stem Cell Reports. 142:3166
  PMID: 26395143
• Tabata et al. (2015) Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta. Sci Rep. 89:5134
  PMID: 25741001
• Singh et al. (2015) Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency. Stem Cells Dev. 5:323
  PMID: 26278042
• Soukup et al. (2015) The Nodal signaling pathway controls left-right asymmetric development in amphioxus. J Clin Invest. 6:5
  PMID: 25954501
• Huang et al. (2015) The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Exp Cell Res. 10:413
  PMID: 25654758
• Hadland et al. (2015) Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. Nat Cell Biol. 125:2032
  PMID: 25866967
• Cebola et al. (2015) TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Mol Cell Endocrinol. 17:615
  PMID: 25915126
• Bras et al. (2015) TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion. Mol Med. 330:29
  PMID: 25064463
• Martínez-Armenta et al. (2015) TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development. J Clin Invest. 400:129
  PMID: 25448845
• Li et al. (2015) MicroRNA-132 enhances transition from inflammation to proliferation during wound healing. Sci Rep. 125:3008
  PMID: 26121747
• Magaña et al. (2014) Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation. Dev Biol. 387:15
  PMID: 24445281
• Fang et al. (2014) Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells. J Pharm Sci Pharmacol. 1:175
  PMID: 25745638
• O'Reilly et al. (2014) Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein. J Biol Chem. 289:9952
  PMID: 24550394
• Orlova et al. (2014) Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts. Arterioscler Thromb Vasc Biol. 34:177
  PMID: 24158517
• Soares et al. (2014) Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions. Cell Stem Cell. 173:53
  PMID: 24440272
• Nishimura et al. (2014) Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells. PLoS One. 9:e91269
  PMID: 24651281
• Aguila et al. (2014) Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for DA Neurons From Human Pluripotent Stem Cells. Stem Cells Transl Med. 3:1032
  PMID: 25024431
• Babu et al. (2014) TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer. 14:113
  PMID: 24555435
• Curado et al. (2014) ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells. Exp Neurol. 34:4389
  PMID: 25266657
• Huang et al. (2014) Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 32:84
  PMID: 24291815
• Rosa et al. (2014) miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells. Dev Biol. 391:81
  PMID: 24709321
• Grunseich et al. (2014) Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients. Neurobiol Dis. 70:12
  PMID: 24925468
• Dai et al. (2014) Combining TGF-β signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes. PLoS One. 4:7323
  PMID: 25471520
• Chen (2014) The development of zebrafish tendon and ligament progenitors. Development. 141:2035
  PMID: 24803652
• Wu et al. (2014) A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. Fibrogenesis Tissue Repair. 289:20193
  PMID: 24895131
• Domev et al. (2014) Immunoevasive pericytes from human pluripotent stem cells preferentially modulate induction of allogeneic regulatory T cells. Stem Cells Transl Med. 3:1169
  PMID: 25205843
• Li et al. (2014) PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism. Cell Signal. 26:1369
  PMID: 24637302
• Wrighton et al. (2014) Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins. J Cell Sci. 111:18126
  PMID: 25422477
• McQualter et al. (2013) TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung. Stem Cell Res. 11:1222
  PMID: 24029687
• Rafiei and Komarova (2013) Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells. BMC Cancer. 13:605
  PMID: 24370273
• Lee-Chang et al. (2013) Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells. J Immunol. 191:4141
  PMID: 24043896
• Kirkeby et al. (2013) Generating regionalized neuronal cells from pluripotency, a step-by-step protocol. Front.Cell Neurosci.. 6:64
  PMID: 23316134
• Kusuma et al. (2013) Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix. Antimicrob Agents Chemother. 110:12601
  PMID: 23858432
• Xia et al. (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 14:638
  PMID: 23792643
• Honda et al. (2013) Naive-like conversion overcomes the limited differentiation capacity of induced pluripotent stem cells. ACS Chem Neurosci. 288:26157
  PMID: 23880763
• Jiang et al. (2013) Translating dosage compensation to trisomy 21. Nature. 500:296
  PMID: 23863942
• Pol et al. (2013) Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate. Stem Cell Res. 247:694
  PMID: 23507034
• Crompton et al. (2013) Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling. PLoS One. 11:1206
  PMID: 24013066
• Razak et al. (2013) Profiling of microRNA in human and mouse ES and iPS cells reveals overlapping but distinct microRNA expression patterns. Nat Neurosci. 8:e73532
  PMID: 24086284
• Briones-Orta et al. (2013) Arkadia regulates tumor metastasis by modulation of the TGF-β pathway. Am J Stem Cells. 73:1800
  PMID: 23467611
• Kreitzer et al. (2013) A robust method to derive functional neural crest cells from human pluripotent stem cells. Nat Methods. 2:119
  PMID: 23862100
• Chetty et al. (2013) A simple tool to improve pluripotent stem cell differentiation. Cell. 10:553
  PMID: 23584186
• Spender et al. (2013) Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas. J Biol Chem. 288:5198
  PMID: 23243310
• Lotz et al. (2013) Sustained levels of FGF2 maintain undifferentiated stem cell cultures with biweekly feeding. PLoS One. 8:e56289
  PMID: 23437109
• Voon et al. (2013) EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway. PLoS One. 8:e70427
  PMID: 23950932
• Shields et al. (2013) Snail cooperates with KrasG12D to promote pancreatic fibrosis. Mol Cancer Res. 11:1078
  PMID: 23761168
• Kim et al. (2013) High-power femtosecond-terahertz pulse induces a wound response in mouse skin. Proc Natl Acad Sci U S A. 3:2296
  PMID: 23907528
• Shalom-Feuerstein et al. (2013) Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET. Neuropsychopharmacology. 110:2152
  PMID: 23355677
• Bialas and (2013) TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci. 16:1773
  PMID: 24162655
• Marlow et al. (2013) A novel model of dormancy for bone metastatic breast cancer cells. Cancer Res. 73:6886
  PMID: 24145351
• Woodruff et al. (2013) The presenilin-1 δE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. Cell Rep. 5:974
  PMID: 24239350
• Davila et al. (2013) Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts. J Neurosci Methods. 216:104
  PMID: 23562599
• Smith et al. (2012) A novel co-operative mechanism linking TGFβ and Lyn kinase activation to Im.nib resistance in chronic myeloid leukaemia cells. PLoS One. 3:518
  PMID: 22643838
• Varela et al. (2012) Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells. Sci Rep. 122:569
  PMID: 22269325
• Neely et al. (2012) DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. Proc Natl Acad Sci U S A. 3:482
  PMID: 22860217
• Outten et al. (2012) High-throughput screening assay for embryoid body differentiation of human embryonic stem cells. Curr Protoc Stem Cell Biol. Chapter 1:Unit 1D.6
  PMID: 22415836
• Sohni et al. (2012) TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence. PLoS One. 7:e47629
  PMID: 23110084
• Boettler et al. (2012) TGF-β blockade does not improve control of an established persistent viral infection. Viral Immunol. 25:232
  PMID: 22620718
• Mak et al. (2012) Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage. Stem Cells Int. 2012:140427
  PMID: 22567022
• Shi et al. (2012) Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses. Cancer Res. 15:477
  PMID: 22306606
• Grönroos et al. (2012) Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes. Mol Cell Biol. 32:2904
  PMID: 22615489
• Luo and Su (2012) Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva. PLoS Biol. 10:e1001402
  PMID: 23055827
• Valdez et al. (2012) Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Nature. 11:676
  PMID: 23122291
• Patsialou et al. (2012) Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Res. 14:R139
  PMID: 23113900
• Rodríguez et al. (2012) Modulation of pluripotency in the porcine embryo and iPS cells. Nat Biotechnol. 7:e49079
  PMID: 23145076
• Hoda et al. (2012) Suppression of AVNA signals inhibits growth of malignant pleural mesothelioma cells. Br J Cancer. 107:1978
  PMID: 23169291
• Rostovskaya et al. (2012) Transposon-mediated BAC transgenesis in human ES cells. Nucleic Acids Res. 40:e150
  PMID: 22753106
• Boeuf et al. (2012) BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors. BMC Cancer. 12:488
  PMID: 23088614
• Denham et al. (2012) Glycogen synthase kinase 3β and act./nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage. J Neurosci. 30:2400
  PMID: 22911885
• Herman-Edelstein et al. (2011) Dedifferentiation of immortalized human podocytes in response to transforming growth factor-β: a model for diabetic podocytopathy. Diabetes. 60:1779
  PMID: 21521871
• Xie et al. (2011) Transforming Growth Factor-β1 Antagonizes Interleukin-5 Pro-Survival Signaling by Activating Calpain-1 in Primary Human Eosinophils. Proc Natl Acad Sci U S A. Suppl 1
  PMID: 24244891
• Duan et al. (2011) Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells. J Clin Cell Immunol. 36:54
  PMID: 21330944
• Shields et al. (2011) Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion. J Biol Chem. 286:10495
  PMID: 21288898
• Holley et al. (2011) Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble Hep. and heparan sulfate saccharides. J Biol Chem. 286:6241
  PMID: 21148566
• Tan et al. (2011) Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4. Nat Cell Biol. 6:e17124
  PMID: 21359200
• Seibler et al. (2011) Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells. Shock. 31:5970
  PMID: 21508222
• Chen et al. (2011) Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism. PLoS One. 4:9
  PMID: 21453480
• Olkhanud et al. (2011) Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4⁺ T cells to T-regulatory cells. Cancer Res. 71:3505
  PMID: 21444674
• Grocott et al. (2011) Neural crest cells organize the eye via TGF-β and canonical Wnt signalling. Stem Cell Reports. 2:265
  PMID: 21468017
• Kurita and Wada (2011) Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-beta signalling. Biol Lett. 7:759
  PMID: 21525052
• Dangi-Garimella et al. (2011) Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression. Oncogene. 30:1002
  PMID: 21057545
• Xi et al. (2011) A poised chromatin platform for TGF-β access to master regulators. Biochem Biophys Res Commun. 147:1511
  PMID: 22196728
• Paek et al. (2011) β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4. Dev Cell. 20:689
  PMID: 21571225
• Hecker et al. (2011) Reversible differentiation of myofibroblasts by MyoD. PLoS One. 317:1914
  PMID: 21440539
• Wilson et al. (2011) Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity. PLoS One. 6:e22842
  PMID: 21909397
• Bedel et al. (2011) Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells. Cancer Res. 71:1615
  PMID: 21257710
• Moyano et al. (2010) Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. Mol Biol Cell. 21:3654
  PMID: 20844080
• Ham et al. (2010) PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins. J Cell Mol Med. 14:1747
  PMID: 19538467
• Hannigan et al. (2010) Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter. J Clin Invest. 120:2842
  PMID: 20592473
• Fong et al. (2010) Tumor-supportive and osteoclastogenic changes induced by breast cancer-derived factors are reversed by inhibition of {gamma}-secretase. J Biol Chem. 285:31427
  PMID: 20679341
• Ishida et al. (2010) Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish. Dev Biol. 340:468
  PMID: 20144602
• James et al. (2010) Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent. Nat Biotechnol. 28:161
  PMID: 20081865
• Redondo et al. (2010) Role of TGF-β1 and MAP kinases in the antiproliferative effect of aspirin in human vascular smooth muscle cells. PLoS One. 5:e9800
  PMID: 20339548
• Alberio et al. (2010) Pig epiblast stem cells depend on act./nodal signaling for pluripotency and self-renewal. Stem Cells Dev. 19:1627
  PMID: 20210627
• Ewan et al. (2010) A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70:5963
  PMID: 20610623
• Wang et al. (2010) Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes. Nat Commun. 4:15
  PMID: 20195389
• Krueger (2010) Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1. PLoS One. 5:e15511
  PMID: 21152098
• Walshe et al. (2009) TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature. PLoS One. 4:e5149
  PMID: 19340291
• Clarke et al. (2009) Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics. Mol Cell Biol. 29:2443
  PMID: 19223462
• Garamszegi et al. (2009) Extracellular matrix-induced gene expression in human breast cancer cells. Mol Cancer Res. 7:319
  PMID: 19276183
• Xiao et al. (2009) SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism. Invest Ophthalmol Vis Sci. 50:1698
  PMID: 19098325
• Cacheaux et al. (2009) Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis. J Neurosci. 29:8927
  PMID: 19605630
• Grande and Patel (2009) Nodal signalling is involved in left-right asymmetry in snails. J Cell Commun Signal. 457:1007
  PMID: 19098895
• Waghabi et al. (2009) Pharmacological inhibition of transforming growth factor β signaling decreases infection and prevents heart damage in acute Chagas' disease. Sci Rep. 53:4694
  PMID: 19738024
• Patsialou et al. (2009) Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res. 69:9498
  PMID: 19934330
• Li et al. (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells. 27:2992
  PMID: 19839055
• Giampieri et al. (2009) Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility. J Biol Chem. 11:1287
  PMID: 19838175
• Roussigne et al. (2009) Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei. Development. 136:1549
  PMID: 19363156
• Patani et al. (2009) act./Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. Oncotarget. 4:e7327
  PMID: 19806200
• Chambers et al. (2009) Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. J Biotechnol. 27:275
  PMID: 19252484
• Zhang et al. (2008) Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood. 111:1933
  PMID: 18042803
• Bharathy et al. (2008) Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype. Cancer Res. 68:1656
  PMID: 18339844
• Stoikos et al. (2008) A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization. Hum Reprod. 23:1447
  PMID: 18434375
• Ding and Warburton (2008) Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-α. Hypertens Res. 375:460
  PMID: 18713620
• Ho and Whitman (2008) TGF-beta signaling is required for multiple processes during Xenopus tail regeneration. Dev Biol. 315:203
  PMID: 18234181
• Gressner et al. (2008) Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor. J Cell Mol Med. 12:2717
  PMID: 18266973
• Yang et al. (2008) Rb/E2F4 and Smad2/3 link survivin to TGF-beta-induced apoptosis and tumor progression. Oncogene. 27:5326
  PMID: 18504435
• Lévesque et al. (2007) Transforming growth factor: beta signaling is essential for limb regeneration in axolotls. PLoS One. 2:e1227
  PMID: 18043735
• Montesano et al. (2007) Low concentrations of transforming growth factor-beta-1 induce tubulogenesis in cultured mammary epithelial cells. BMC Dev Biol. 7:7
  PMID: 17288590
• Dai et al. (2007) Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules. Mol Biol Cell. 18:2264
  PMID: 17429065
• Hagos et al. (2007) The role of maternal act.-like signals in zebrafish embryos. Dev Biol. 309:245
  PMID: 17692308
• Castañares et al. (2007) Signaling by ALK5 mediates TGF-β-induced ET-1 expression in endothelial cells: a role for migration and proliferation. Genes Dev. 120:1256
  PMID: 17376964
• Horowitz et al. (2007) Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts. Cell Signal. 19:761
  PMID: 17113264
• Ivens et al. (2007) TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brain. 130:535
  PMID: 17121744
• Zhu et al. (2007) AVNacutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I. J Neurosci. 27:13770
  PMID: 18077689
• Shi-Wen et al. (2006) Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. Exp Cell Res. 26:5518
  PMID: 16809784
• Zhao et al. (2006) PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. Biochem Biophys Res Commun. 350:385
  PMID: 17010940
• Chen et al. (2006) Identification of phosphatases for Smad in the BMP/DPP pathway. Sci Rep. 20:648
  PMID: 16510868
• Ninomiya et al. (2006) Transforming growth factor-β signaling enhances transdifferentiation of macrophages into smooth muscle-like cells. Mol Cell Biol. 29:269
  PMID: 16778334
• Ho et al. (2006) Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo. Dev Biol. 295:730
  PMID: 16684517
• Anumanthan et al. (2005) Restoration of TGF-beta signalling reduces tumorigenicity in human lung cancer cells. Br J Cancer. 93:1157
  PMID: 16251876
• Mimura et al. (2005) Tra.Mab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma. Clin Cancer Res. 11:4898
  PMID: 16000588
• König et al. (2005) TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J Cell Biol. 168:1077
  PMID: 15781474
• Chen et al. (2005) Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/act.-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease. Am J Pathol. 167:1699
  PMID: 16314481

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• (6)

• Effective inhibition of TGFb family receptors

  Name: Paul Humphreys
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: hESCs/Tc28a2s
  I have used SB431542 for both selective inhibition of TGFb family receptors in TGFb activity assays and to drive differentiation of pluripotent stem cells towards mesodermal tissues.Concentration: 1nM working
  If possible perform titration of SB431542 with TGFb signalling output depending upon cell type or application.
  

• Differentiation to cortical neurons

  Name: Julieta O'Flaherty
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: Induced pluripotent stem cells
  I routinely use this product to differentiate human induced pluripotent stem cells into cortical neurons. I use it at 10uM. Once reconstituted, I would only store it for a maximum of one month in -80C
  Keep at -80C for a maximum of 1 month
  

• Inhibition of pSmad 2/3 in a human epithelial cell line

  Name: Anonymous
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: A549
  Tested a human lung epithelial cell line pretreated with SB431542 at either 10, 1 or 0.1uM for 30 min and then added TGFb1 at 5ng/ml in two different matrices. Incubated 24hr and then lysed cells to look at pSmad 2/3 levels by immunoassay

• iPSC differentiation

  Name: Stephanie Hsiao
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: iPSC
  Differentiation of human iPSCs into hematopoietic progenitor cells
  iPSC culture medium with 4 uM SB431542
  

• For hPSC culture

  Name: Anonymous
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: Human PSC
  For hPSC culture, final concentration 10 μM.
  Make 100µl aliquots and keep them at −20 °C for up to 6 months.
  PMID: PMID, 27841875
  

• 3D cultures

  Name: Anonymous
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: iPS cells
  Worked consistently in generation of cerebral organoids from human iPS cells

• Dífferentiation of iPSC into neural progentor cells

  Name: Vladimir Milenkovic
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: iPSC
  Human induced pluripotent stem cells (iPSCs) were differentiated into neural progenitor cells (NPCs) as described in Chambers et al. 2009 (PMID: 19252484.) SB431542 was used at 20uM. Differentiated NPCs were then immunostained using PAX6 monoclonal Ab, and we had over 80% of PAX6 positive cells.
  

• Works really well as a TGF-beta receptor Inhibitor

  Name: Anonymous
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: Breast Cancer Cells
  I used it as a TGF-beta receptor Inhibitor in Breast cancer Cells to study the impact of blocking TGF-beta pathway on EMT. I used the concentration 5uM and it works really well.

• endothelial differentiation

  Name: Anonymous
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: stem cells differentiated endothelial cells
  Stems cells undergoing differentiation to endothelial cells utilize addition of SB 431542. FLK+ve cells cultured with SB 431542 revealed colonies of endothelial cells (arrows)
  

• Works great.

  Name: Anonymous
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: Induced pluripotent stem cells
  I used this product for differentiation of iPSCs into dopaminergic neurons according to the protocol published in Kriks et al, 2011.I used the concentration 10uM and it works really well.

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