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SB 431542

Cat.No. 1614 - SB 431542 | C22H16N4O3 | CAS No. 301836-41-9

Key Product Details

Description: Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity: ≥99% (HPLC)

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Citations (257)

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Customer Reviews

5 out of 5
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  • For hPSC culture
    Name: Anonymous | 30th Jun 2020
    Species: Human
    Assay Type: In Vitro
    For hPSC culture, final concentration 10 μM.
  • Dífferentiation of iPSC into neural progentor cells
    Name: Vladimir Milenkovic | 15th Jan 2020
    Species: Human
    Assay Type: In Vitro
    Human induced pluripotent stem cells (iPSCs) were differentiated into neural progenitor cells (NPCs) as described in Chambers et al. 2009 (PMID: 19252484.) SB431542 was used at 20uM. Differentiated NPCs were then immunostained using PAX6 monoclonal Ab, and we had over 80% of PAX6 positive cells.
  • endothelial differentiation
    Name: Anonymous | 1st May 2018
    Species: Human
    Assay Type: In Vitro
    Stems cells undergoing differentiation to endothelial cells utilize addition of SB 431542. FLK+ve cells cultured with SB 431542 revealed colonies of endothelial cells (arrows)
  • Works great.
    Name: Anonymous | 4th Jan 2018
    Species: Human
    Assay Type: In Vitro
    I used this product for differentiation of iPSCs into dopaminergic neurons according to the protocol published in Kriks et al, 2011.I used the concentration 10uM and it works really well.

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