SU 5402

Catalog # 3300 | Tocris Bioscience a Bio-Techne Brand

Potent FGFR and VEGFR inhibitor

Key Product Details

Description:	Potent FGFR and VEGFR inhibitor
Chemical Name:	2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
Purity:	≥95% (HPLC)
Molecular Weight:	296.32

View Full Technical Details for SU 5402

Biological Activity for SU 5402

SU 5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC₅₀ values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo. Also attenuates integrin β4-induced differentiation of neural stem cells. Supports mESC self-renewal.

For more information about how SU 5402 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs

Technical Data for SU 5402

M. Wt	296.32
Formula	C₁₇H₁₆N₂O₃
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	215543-92-3
PubChem ID	5289418
InChi Key	JNDVEAXZWJIOKB-JYRVWZFOSA-N
Smiles	CC1=CNC(\C=C(C2=CC=CC=C2N3)/C3=O)=C1CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SU 5402

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	29.63	100

Preparing Stock Solutions for SU 5402

The following data is based on the product molecular weight 296.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.37 mL	16.87 mL	33.75 mL
5 mM	0.67 mL	3.37 mL	6.75 mL
10 mM	0.34 mL	1.69 mL	3.37 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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References for SU 5402

References are publications that support the biological activity of the product.

Su Neural stem cell differentiation is mediated by integrin beta4 in vitro. Int.J.Biochem.Cell Biol. 2009 PMID: 18834954
Buehr Capture of authentic embryonic stem cells from rat blastocysts. Cell 2008 PMID: 19109897
Tanaka FGF-induced vesicular release of sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 2005 PMID: 15889083
Paterson Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma. Br.J.Haematol. 2004 PMID: 14871245
Sun Design, synthesis and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF and PDGF receptor tyrosine kinases. J.Med.Chem. 1999 PMID: 10602697

Citations for SU 5402 (18)

Showing 1 - 10 of 18 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SU 5402 include:

Gibb et al. (2018) Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development. Development. 145
PMID: 30355727
Rodrigues (2017) Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells. PNAS. 114(12):3139
PMID: 28270602
Yan et al. (2017) Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Sci Rep. 7:45796
PMID: 28378824
Yang et al. (2017) Establishment of mouse expanded potential stem cells. Nature. 550:393
PMID: 29019987
Li et al. (2016) FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation. Diabetes. 65:96
PMID: 26420862
Cunningham et al. (2015) Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis. PLoS One. 10:e0137894
PMID: 26368825
Benzina et al. (2015) A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. PLoS One. 72:3559
PMID: 25894690
Neugebauer and Yost (2014) FGF signaling is required for brain left-right asymmetry and brain midline formation. Dev Biol. 386:123
PMID: 24333178
Dai et al. (2014) Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. Cell Death Differ. 21:568
PMID: 24336047
Bernet et al. (2014) p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Dev Biol. 20:265
PMID: 24531379
Dean et al. (2014) Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. Stem Cell Res Ther. 9:20
PMID: 25212830
Chen (2014) The development of zebrafish tendon and ligament progenitors. Development. 141:2035
PMID: 24803652
Hashiguchi and Mullins (2013) Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Development. 140:1970
PMID: 23536566
Clanton et al. (2013) Fgf signaling governs cell fate in the zebrafish pineal complex. Development. 140:323
PMID: 23250206
Borroto-Escuela et al. (2012) The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity. J Neurosci. 32:6295
PMID: 22553035
Rankin et al. (2012) Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. Cell Mol Life Sci. 139:3010
PMID: 22791896
Tan et al. (2011) Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4. Nat Med. 6:e17124
PMID: 21359200
Sato et al. (2011) FGF8 signaling is chemotactic for cardiac neural crest cells. Neural Dev. 354:18
PMID: 21419761

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Showing 1 - 10 of 18 citations Showing All

Product Documents for SU 5402

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.