SU 5402
Tocris Bioscience, part of Bio-Techne | Catalog # 3300
Potent FGFR and VEGFR inhibitor
Key Product Details
Description
Potent FGFR and VEGFR inhibitor
Alternative Names
PF-02969207,PNU-0290908
Product Description
SU 5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo. Also attenuates integrin β4-induced differentiation of neural stem cells. Supports mESC self-renewal. Can be used in a small molecule cocktail to generate cortical neurons from hiPSCs (see our protocol below).For more information about how SU 5402 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs
Product Specifications
Molecular Weight
296.32
Formula
C17H16N2O3
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
CAS Number
215543-92-3
PubChem ID
5289418
InChI Key
JNDVEAXZWJIOKB-JYRVWZFOSA-N
SMILES
CC1=CNC(\C=C(C2=CC=CC=C2N3)/C3=O)=C1CCC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.63 | 100 |
Preparing Stock Solutions
for SU 5402
The following data is based on the product molecular weight 296.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.87 mL | 33.75 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Buehr Capture of authentic embryonic stem cells from rat blastocysts. Cell 2008 PMID: 19109897
- Su Neural stem cell differentiation is mediated by integrin beta4 in vitro. Int.J.Biochem.Cell Biol. 2009 PMID: 18834954
- Paterson Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma. Br.J.Haematol. 2004 PMID: 14871245
- Tanaka FGF-induced vesicular release of sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 2005 PMID: 15889083
- Sun Design, synthesis and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF and PDGF receptor tyrosine kinases. J.Med.Chem. 1999 PMID: 10602697
Product Specific Notices for SU 5402
For research use only
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