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FGF Receptor Inhibitors Products

FGF activity is mediated by a family of type I transmembrane tyrosine kinases, which undergo dimerization and autophosphorylation after ligand binding. Five distinct genes encode closely related FGF receptors, FGF R1 through 5. FGF Rs contain three Ig-like domains and a stretch of acidic residues between the first and second Ig-like domains. FGF R1, 2, 3, and -4 have a cytoplasmic split tyrosine-kinase domain, but FGF R5 does not. Multiple forms of FGF R1, 2, and 3 are generated by alternative splicing

9 results for "FGF Receptor Inhibitors" in Products

FGF Receptor Inhibitors Products

FGF activity is mediated by a family of type I transmembrane tyrosine kinases, which undergo dimerization and autophosphorylation after ligand binding. Five distinct genes encode closely related FGF receptors, FGF R1 through 5. FGF Rs contain three Ig-like domains and a stretch of acidic residues between the first and second Ig-like domains. FGF R1, 2, 3, and -4 have a cytoplasmic split tyrosine-kinase domain, but FGF R5 does not. Multiple forms of FGF R1, 2, and 3 are generated by alternative splicing

9 results for "FGF Receptor Inhibitors" in Products

Potent FGFR and VEGFR inhibitor

Potent VEGFR, PDGFR and FGFR inhibitor

Potent, irreversible FGFR inhibitor

Selective FGFR inhibitor

FGFR1 and -3 inhibitor

PDGFR, VEGFR and FGFR inhibitor

Potent inhibitor of VEGFR, PDGFR and FGFR

Potent multi-kinase and pan-Bcr-Abl inhibitor

Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1

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