Nintedanib

Name: Nintedanib
Brand: Tocris Bioscience
SKU: 7049

Tocris Bioscience, part of Bio-Techne | Catalog # 7049

Citations (5)

COA / SDS

Potent VEGFR, PDGFR and FGFR inhibitor

Key Product Details

Description:	Potent VEGFR, PDGFR and FGFR inhibitor
Chemical Name:	Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate
Purity:	≥98%
Molecular Weight:	539.64

View Full Technical Details for Nintedanib

Technical Data
Citations

Biological Activity for Nintedanib

Nintedanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC₅₀ values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC₅₀ values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.

Technical Data for Nintedanib

M. Wt	539.64
Formula	C₃₁H₃₃N₅O₄
Storage	Store at -20°C
Purity	≥98%
CAS Number	656247-17-5
PubChem ID	135423438
InChi Key	XZXHXSATPCNXJR-ZIADKAODSA-N
Smiles	COC(=O)C1=CC=C2C(NC(=O)\C2=C(/NC2=CC=C(C=C2)N(C)C(=O)CN2CCN(C)CC2)C2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nintedanib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	1.08	2 with gentle warming

Preparing Stock Solutions for Nintedanib

The following data is based on the product molecular weight 539.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	92.65 mL	463.27 mL	926.54 mL
0.1 mM	18.53 mL	92.65 mL	185.31 mL
0.2 mM	9.27 mL	46.33 mL	92.65 mL
1 mM	1.85 mL	9.27 mL	18.53 mL

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References for Nintedanib

References are publications that support the biological activity of the product.

Hilberg BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 2008 PMID: 18559524