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FGF Receptor Inhibitors: Small Molecules and Peptides

FGF activity is mediated by a family of type I transmembrane tyrosine kinases, which undergo dimerization and autophosphorylation after ligand binding. Five distinct genes encode closely related FGF receptors, FGF R1 through 5. FGF Rs contain three Ig-like domains and a stretch of acidic residues between the first and second Ig-like domains. FGF R1, 2, 3, and -4 have a cytoplasmic split tyrosine-kinase domain, but FGF R5 does not. Multiple forms of FGF R1, 2, and 3 are generated by alternative splicing

9 results for "FGF Receptor Inhibitors Small Molecules and Peptides" in Products

FGF Receptor Inhibitors: Small Molecules and Peptides

FGF activity is mediated by a family of type I transmembrane tyrosine kinases, which undergo dimerization and autophosphorylation after ligand binding. Five distinct genes encode closely related FGF receptors, FGF R1 through 5. FGF Rs contain three Ig-like domains and a stretch of acidic residues between the first and second Ig-like domains. FGF R1, 2, 3, and -4 have a cytoplasmic split tyrosine-kinase domain, but FGF R5 does not. Multiple forms of FGF R1, 2, and 3 are generated by alternative splicing

9 results for "FGF Receptor Inhibitors Small Molecules and Peptides" in Products

Potent FGFR and VEGFR inhibitor

Potent VEGFR, PDGFR and FGFR inhibitor

Potent, irreversible FGFR inhibitor

Selective FGFR inhibitor

FGFR1 and -3 inhibitor

PDGFR, VEGFR and FGFR inhibitor

Potent inhibitor of VEGFR, PDGFR and FGFR

Potent multi-kinase and pan-Bcr-Abl inhibitor

Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1

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