Cediranib

Name: Cediranib
Brand: Tocris Bioscience
SKU: 7454

Tocris Bioscience a Bio-Techne Brand

Catalog # 7454

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Potent inhibitor of VEGFR, PDGFR and FGFR
Chemical Name:	4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline
Purity:	≥98% (HPLC)
Molecular Weight:	450.51

View Full Technical Details for Cediranib

Biological Activity for Cediranib

Cediranib is a highly potent and ATP-competitive inhibitor of VEGFR2 (IC₅₀ = 50 values are 2, 3, 5, 5, 26 and 36 nM, respectively), and inhibits CSF-1R, Src, and Abl (IC₅₀ values are 110, 130 and 260 nM, respectively). Cediranib induces hypoxia, prevents VEGF-induced angiogenesis and suppresses homology-directed DNA repair (HDR) factors BRCA1/2 and RAD51. Cediranib decreases cell motility, proliferation and cell viability. Cediranib is active in vivo.

Compound Libraries for Cediranib

Cediranib is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Cediranib

M. Wt	450.51
Formula	C₂₅H₂₇FN₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	288383-20-0
PubChem ID	9933475
InChi Key	XXJWYDDUDKYVKI-UHFFFAOYSA-N
Smiles	FC1=C(OC2=NC=NC=3C=C(OCCCN4CCCC4)C(OC)=CC23)C=CC=5NC(=CC15)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cediranib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.05	100
	ethanol	45.05	100

Preparing Stock Solutions for Cediranib

The following data is based on the product molecular weight 450.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.10 mL	22.20 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Cediranib

References are publications that support the biological activity of the product.

Momeny Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells Eur.J.Pharmacol. 2020 PMID: 32593665
Kaplan Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51. Sci.Transl.Med. 2019 PMID: 31092693
Wedge AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res. 2005 PMID: 15899831

Citations for Cediranib

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.