Cediranib

Name: Cediranib
Brand: Tocris Bioscience
SKU: 7454

Tocris Bioscience, part of Bio-Techne | Catalog # 7454

Citations (1)

COA / SDS

Potent inhibitor of VEGFR, PDGFR and FGFR

Key Product Details

Description:	Potent inhibitor of VEGFR, PDGFR and FGFR
Chemical Name:	4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline
Purity:	≥98% (HPLC)
Molecular Weight:	450.51

View Full Technical Details for Cediranib

Technical Data
Citations

Biological Activity for Cediranib

Cediranib is a highly potent and ATP-competitive inhibitor of VEGFR2 (IC₅₀ = <1 nM). Cediranib also potently inhibits PDGFR1, VEGFR3, VEGFR1, c-Kit, PDGFR2 and FGFR1 (IC₅₀ values are 2, 3, 5, 5, 26 and 36 nM, respectively), and inhibits CSF-1R, Src, and Abl (IC₅₀ values are 110, 130 and 260 nM, respectively). Cediranib induces hypoxia, prevents VEGF-induced angiogenesis and suppresses homology-directed DNA repair (HDR) factors BRCA1/2 and RAD51. Cediranib decreases cell motility, proliferation and cell viability. Cediranib is active in vivo.

Compound Libraries for Cediranib

Cediranib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Cediranib

M. Wt	450.51
Formula	C₂₅H₂₇FN₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	288383-20-0
PubChem ID	9933475
InChi Key	XXJWYDDUDKYVKI-UHFFFAOYSA-N
Smiles	FC1=C(OC2=NC=NC=3C=C(OCCCN4CCCC4)C(OC)=CC23)C=CC=5NC(=CC15)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cediranib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.05	100
	ethanol	45.05	100

Preparing Stock Solutions for Cediranib

The following data is based on the product molecular weight 450.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.10 mL	22.20 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for Cediranib

References are publications that support the biological activity of the product.

Kaplan Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51. Sci.Transl.Med. 2019 PMID: 31092693
Momeny Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells Eur.J.Pharmacol. 2020 PMID: 32593665
Wedge AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res. 2005 PMID: 15899831