CHIR 99021

Name: CHIR 99021
Brand: Tocris Bioscience
SKU: TB4423-GMP

Tocris Bioscience a Bio-Techne Brand

Catalog # TB4423-GMP

Citations (1)

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Key Product Details

Description:	CHIR 99021 synthesized to cGMP guidelines
Chemical Name:	6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Purity:	≥99%
Molecular Weight:	465.34

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Biological Activity for CHIR 99021

CHIR 99021 synthesized to cGMP guidelines. Suitable for use as an ancillary reagent in the further manufacturing of cell therapies.

For more information about how CHIR 99021 may be used, please see our protocols: Transdifferentiating Fibroblasts into Neurons, Culturing Transcriptomically Distinct Pluripotent mESCs, Converting Fibroblasts into Cardiomyocytes (9C Cocktail), Human iPSC-derived Myoblasts, Reprogramming MEFs into Skeletal Muscle Progenitors, Highly Efficient Generation of CiPSCs from MEFs, Generation of Kidney Organoids from hPSCs.

Research use only CHIR 99021 also available.

Current Good Manufacturing Practice (cGMP) is a harmonized set of guidelines that when implemented will ensure safe, reliable, consistent and quality-assured products. The Tocris range of cGMP small molecules is manufactured following relevant sections of ICH Q7 guidelines. Our highly skilled team has full control over the cGMP process, meaning we can ensure: a quality-assured manufacturing system, batch-to-batch consistency, consistent supply, traceability from starting material to final product, and animal-free production. Find out more about the Tocris range of cGMP compounds.

Technical Data for CHIR 99021

M. Wt	465.34
Formula	C₂₂H₁₈Cl₂N₈
Storage	Store at -20°C (± 5°C)
Purity	≥99%
CAS Number	252917-06-9
InChi Key	FHYUGAJXYORMHI-UHFFFAOYSA-N
Smiles	ClC(C=C1Cl)=CC=C1C2=NC(NCCNC3=CC=C(C#N)C=N3)=NC=C2C4=NC=C(C)N4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

This product is intended for research use or further manufacturing only.

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Citations for CHIR 99021 (1)

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Citations are publications that use Bio-Techne products. Selected citations for CHIR 99021 include:

Nguyen et al. (2019) Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells. Stem Cells Int. 2019:3298432
PMID: 31191670

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Product Documents for CHIR 99021

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.