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R&D Systems Proteins for Coronavirus Research

R&D Systems, a Bio-Techne brand, offers a wide selection of bioactive recombinant proteins for COVID-19 research, including the U.K., South African, and Brazilian variant Spike proteins. As the COVID-19 pandemic evolves and new mutant variants are identified, we are striving to provide researchers with the tools they need in the fight against coronavirus. We now offer over 100 different Spike proteins including the receptor binding domain (RBD), S1, S2, and full ectodomain Spike proteins from SARS-CoV-2 to SARS and MERS coronaviruses and more. For human ACE-2, His-tagged, Fc chimera, and Avi-tag options are available as well has ACE-2 from 8 other species. Every protein we manufacture for coronavirus research is produced and purified in-house and is rigorously tested for bioactivity and lot-to-lot consistency.

New SARS-CoV-2 Variants

The emergence of the U.K. (B.1.1.7), South African (B.1.351), and Brazilian (P.1) variants across the globe has heightened our level of concern about SARS-CoV-2’s ability to evolve into a more infectious and deadly virus. As the SARS-CoV-2 virus mutates and new variants of concern are identified, we are quickly developing the latest mutant proteins to enable scientists to advance their research and stay ahead in this ever-changing COVID-19 landscape.

SARS-CoV-2 coronavirus virion particles with highlighted mutant spike proteins

Spike and ACE-2 Products:

Spike Proteins

Quality spike proteins that you can rely on with high ACE-2 binding and lot-to-lot consistency. Browse our selection of over 100 different spike proteins from SARS-CoV-2, SARS, MERS, and other coronaviruses.

Spike Mutant Proteins

Multiple mutant spike proteins are now available covering the major variants of concern, UK variant, South African variant, and Brazilian variant.


Bioactive human ACE-2 protein with documented enzymatic activity and binding to the SARS-CoV-2 spike protein. His tagged and Fc chimera human ACE-2 as well as ACE-2 from 9 different species available.

Additional Coronavirus Resources

Coronavirus FAQs

Have questions about our Spike proteins? Our protein technical team answers frequently asked questions about our coronavirus proteins.

New Research Tools to Help the Fight Against SARS-CoV-2 Webinar

In this webinar, Bio-Techne scientists are joined by Joep Beumer, from the Hans Clevers lab at the Hubrecht Institute, to discuss different aspects of COVID-19 research including the use of intestinal organoids to model SARS-CoV-2 infection.

Improved COVID-19 Research with Bio-Techne Automated Platforms Webinar

Watch this webinar to learn how the automated platforms from our ProteinSimple brand can be utilized for COVID-19 basic research and serological assay development.