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R&D Systems Proteins for Coronavirus Research

R&D Systems, a Bio-Techne brand, offers a wide selection of bioactive recombinant proteins for COVID-19 research, including the U.K., South African, and Brazilian variant Spike proteins. As the COVID-19 pandemic evolves and new mutant variants are identified, we are striving to provide researchers with the tools they need in the fight against coronavirus. We now offer over 100 different Spike proteins including the receptor binding domain (RBD), S1, S2, and full ectodomain Spike proteins from SARS-CoV-2 to SARS and MERS coronaviruses and more. For human ACE-2, His-tagged, Fc chimera, and Avi-tag options are available as well has ACE-2 from 8 other species. Every protein we manufacture for coronavirus research is produced and purified in-house and is rigorously tested for bioactivity and lot-to-lot consistency.

New SARS-CoV-2 Variants

The emergence and widespread domination of the Delta variant has bolstered COVID-19 causing an increase in new cases and higher mortality. Now, the Omicron variant is beginning to outcompete Delta, spreading at an unprecedented pace and raising questions about transmissibility and vaccine efficacy. At Bio-Techne, we are working hard to develop the vital research tools required for studying Omicron including quality
Spike proteins and antibodies to enable scientists to quickly advance their research.

Spike and ACE-2 Products:

Artistic image of spike protein on the surface of SARS-CoV-2 virus

Spike Proteins

Quality spike proteins that you can rely on with high ACE-2 binding and lot-to-lot consistency. Browse our selection of over 100 different spike proteins from SARS-CoV-2, SARS, MERS, and other coronaviruses.

Artistic image of mutant spike protein on the surface of SARS-CoV-2 variant of concern

Spike Mutant Proteins

Multiple mutant spike proteins are now available covering the major variants of concern, UK variant, South African variant, and Brazilian variant.

Artistic image of ACE-2 protein on a cell surface


Bioactive human ACE-2 protein with documented enzymatic activity and binding to the SARS-CoV-2 spike protein. His tagged and Fc chimera human ACE-2 as well as ACE-2 from 9 different species available.

Additional Coronavirus Resources

Coronavirus FAQs 290x200

Coronavirus FAQs

Have questions about our Spike proteins? Our protein technical team answers frequently asked questions about our coronavirus proteins.

Anthony Person Ph.D.

New Research Tools to Help the Fight Against SARS-CoV-2 Webinar

In this webinar, Bio-Techne scientists are joined by Joep Beumer, from the Hans Clevers lab at the Hubrecht Institute, to discuss different aspects of COVID-19 research including the use of intestinal organoids to model SARS-CoV-2 infection.

Annegret Boge Ph.D. 290x200

Improved COVID-19 Research with Bio-Techne Automated Platforms Webinar

Watch this webinar to learn how the automated platforms from our ProteinSimple brand can be utilized for COVID-19 basic research and serological assay development.