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cGMP Small Molecules as Ancillary Materials

Stem cells offer great potential for use as therapies in regenerative medicine. They can be used to generate cells to replace lost or unhealthy cells in a wide range of conditions including trauma, diabetes and Parkinson’s disease. The small molecules used as ancillary materials in the generation of stem cell therapies are required to be safe, reliable, consistent and quality-assured in order to ensure the safety of the stem cell therapy. Our GMP Small Molecules, manufactured according to cGMP guidelines, provide this assurance.

Available GMP Small Molecules

Product Name

Catalog #


CHIR 99021


GSK-3 Inhibitor; WNT pathway activator. Enables reprogramming of human somatic cells into iPSCs

SB 431542


TGF Beta 1 (TGF-β1), ALK4 and ALK7 Inhibitor. Replaces SOX2 in reprogramming of fibroblasts to iPSCs

XAV 939


Tankyrase Inhibitor; inhibits WNT signaling. Promotes cardiomyocyte differentiation from ESCs



Selective ROCK Inhibitor. Increases survival of ESCs and
iPSCs undergoing cryopreservation

View More GMP Products

GMP Protein Bottles

GMP Proteins

Our large range of GMP proteins, including cytokines and growth factors, is backed by our dedication to providing cell therapy manufacturers with a consistent, safe, and traceable supply of reagents.

StemXVivo Media Bottle

GMP Culture Media

All components of ex vivo cell manufacturing need to be controlled, traceable, and scalable, including media and serum. Our GMP media production facility provides off-the-shelf and custom media for the further manufacture of immune and stem cell therapies.


GMP Small Molecule Resources

Brochure: Pioneering Cell & Gene Therapy Solutions

Our brochure provides an overview of the innovative products and services available from Bio-Techne to help further your cell and gene therapy research. 

Poster: Stem Cell Workflow Using Small Molecules

Our Stem Cell Workflow poster summarizes how small molecules have been used in protocols across the stem cell workflow, and highlights some of the key advantages of using small molecules. 

Protocols: Key Stem Cell Protocol Highlights

Our Stem Cell Protocol snapshots highlight how small molecules may be used in place of or alongside proteins in cell culture, reprogramming and differentiation procedures. 

Background Information