

E3 Ligases + Targeted Protein Degradation
E3 Ligases + Targeted Protein Degradation
- Single-subunit E3 Ligases
- Multi-subunit E3 Complexes including Neddylated Cullins
- E3 Activity Kits
- E3 Inhibitors
- PROTACs® and Targeted Protein Degradation
There are over 600 genes that code for E3 ligases in the human genome. E3 ligases typically confer target specificity for ubiquitination in addition to the enzymatic role of adding ubiquitin. Several E3 ligases have become popular components used with small molecule degraders in the promising field of targeted protein degradation (TPD).

Proteasome
Proteasome
The proteasome is the primary way cells degrade proteins. This mutiprotein complex containing multiple proteases forms a tube-like structure where proteins are degraded as they pass through. Bioactive, purified proteasomes are ideal for studying in vitro degradation of a protein of interest.

Accessory Proteins and TUBEs
Accessory Proteins and TUBEs
- Accessory Proteins
- TUBEs (Tandem Ubiquitin Binding Entities)
Accessory proteins are kinases and heat shock proteins that act as E3 ligase cofactors and proteins involved in aggresomal disorders such as Tau and alpha-Synuclein. TUBEs stand for Tandem Ubiquitin Binding Entities, useful for the isolation and identification of ubiquitinated molecules.
Background Information
R&D Systems Ubiquitin Proteasome Group, formerly known as Boston Biochem, has over 20 years of experience developing products for studying ubiquitin proteasome biology. Our experience in protein expression, purification, and assay development, coupled with our close relationship with the ubiquitin proteasome system research community, has allowed us to build the most comprehensive portfolio of tools for ubiquitin research. Our catalog includes the highest quality ubiquitin and ubiquitin-like proteins, E1, E2, and E3 enzymes, deubiquitinating enzymes, and multienzyme complexes, including neddylated cullins for targeted protein degradation (TPD) assays. As the field continues to evolve, we remain dedicated to providing ubiquitin proteasome researchers with the tools that are needed to accelerate both basic protein degradation research and drug discovery efforts. If there is a reagent that you can’t find on our website, please contact us and our Custom Protein Services team will work with you to develop a customized product that meets your needs.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.