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TGF-beta Receptor Inhibitors Small Molecule
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2939/10
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Key Product Details

Description: Selective inhibitor of TGF-βRI, ALK4 and ALK7
Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity: ≥98% (HPLC)
Molecular Weight: 421.52

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Citations (77)

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Customer Reviews (10)

4.8 out of 5
10 customer ratings
5 stars
80%
4 stars
20%
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  • Works perfectly
    Name: Toni Johansson
    Species: Human
    Assay Type: In Vitro
    To grow primary basal cells
    A 83-01 Serum 2939
  • Works well with liver organoids
    Name: Gautam Kok
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Liver organoids
    Used in expansion medium for culturing liver organoids
    A 83-01 Serum 2939
  • It worked good
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: iPSC
    Reprogramming media comprises of 3 μM CHIR99021 and 0.5 μM A-83-01.
    The cells were then maintained in RM 15 days with fresh media every other day
    A 83-01 Serum 2939
  • For TGFB inhibition
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Neural Stem Cells
    Cells are treated with 1 mM A83-01 to inhibit canonical TGFB signaling
    A 83-01 Serum 2939
  • Neural Induction Conditions
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: H9
    2 μM A83–01
    A 83-01 Serum 2939
  • To start reprogramming, cultures were switched to reprogramming medium (ES medium supplemented with 1 mM A83-01)
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: ipsc
    To start reprogramming, cultures were switched to reprogramming medium (ES medium supplemented with 10 mM Parnate, 3 mM Chir99021, 1 mM A83-01, and 10 mM Forskolin)
    A 83-01 Serum 2939
  • good for cell culture
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: ipsc
    add to cell culture to do 3d culture
    A 83-01 Serum 2939
  • works great for TGFB inhibition
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    used it to grow primary basal cells
  • for growing cells
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    used it to grow human airway basal cells
  • A 83-01 Inhibit TGFb1-activated Cellular Fibrosis in Human Mϋller Cells
    Name: Ying Yu
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Mϋller cells
    Human MOI-M1 Mϋller cells seeded in tissue culture (TC)-treated plastic plate (BD). Serum starvation by DMEM medium supplemented with 1% FBS for 24h. Pretreated Human Mϋller cell with A83-01 at 0, 0.25, 0.5, 1 and 2uM for 2h. Then added 0-10 ng/mL TGFb1 for 48h. Picro-Sirius red staining, elution, and OD 540nm measurement for the fibrosis

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