Key Product Details
Description: | Adenylyl cyclase activator |
Chemical Name: | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 410.51 |
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Citations for Forskolin (86)
Citations are publications that use Bio-Techne products. Selected citations for Forskolin include:
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Post et al.
(2020)
Snake venom gland organoids
Cell.
180:233
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Delpiano et al.
(2019)
Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells.
Front Pharmacol.
9:1462
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Sachs et al.
(2019)
Long-term expanding human airway organoids for disease modeling.
EMBO J.
38
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Jewell et al.
(2019)
GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.
Elife.
8
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Saito et al.
(2019)
Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.
Cell Rep.
27:1265
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Franchini et al.
(2019)
Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition.
iScience.
19:927
PMID: 31518901 -
French et al.
(2019)
Dual-Mode FRET and BRET Sensors for Detecting cAMP Dynamics.
ACS Omega.
4:15504
PMID: 31572851 -
Schnúr et al.
(2019)
Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia.
Sci Rep.
9:12706
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Segal et al.
(2019)
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Nat Commun.
10:3350
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Garcia et al.
(2019)
Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
Front Neurosci.
13:669
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Chiu et al.
(2019)
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Cell Rep.
28:332
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Cordonier et al.
(2019)
Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 Expression.
J Endocr Soc.
3:1246
PMID: 31214662 -
Liu et al.
(2018)
CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency.
Cell Stem Cell..
22:252
PMID: 29358044 -
Tozzi et al.
(2018)
DA D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson�s disease.
Cell Death Dis.
9(2):204
PMID: 29434188 -
Burdyga et al.
(2018)
Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
Proc Natl Acad Sci U S A..
115(28):E6497
PMID: 29941564 -
Patra et al.
(2018)
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Nat Cell Biol.
20:811
PMID: 29941929 -
Costa et al.
(2018)
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome.
Front Mol Neurosci.
11:353
PMID: 30333723 -
Ford et al.
(2018)
A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.
Dev Cell.
47:509
PMID: 30458140 -
Mo et al.
(2018)
MBD1 Contributes to the Genesis of Acute Pain and Neuropathic Pain by Epigenetic Silencing of Oprm1 and Kcna2 Genes in Primary Sensory Neurons.
J Neurosci.
38:9883
PMID: 30266739 -
Noh et al.
(2018)
Specific autophagy and ESCRT components participate in the unconventional secretion of CFTR.
Autophagy.
14:1761
PMID: 29969945 -
Gauster et al.
(2018)
Downregulation of p53 drives autophagy during human trophoblast differentiation.
Cell Mol Life Sci.
75:1839
PMID: 29080089 -
Luo
(2017)
β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
Scientific Reports.
7:39905
PMID: 28051147 -
Li et al.
(2017)
Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression.
Theranostics.
7:4671
PMID: 29187895 -
Demeautis et al.
(2017)
Multiplexing PKA and ERK12 kinases FRET biosensors in living cells using single excitation wavelength dual colour FLIM.
Sci Rep.
7:41026
PMID: 28106114 -
Al-Taei et al.
(2017)
Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer.
Oncoimmunology.
6:e1268308
PMID: 28344879 -
Burgueño et al.
(2017)
A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses.
Sci Rep.
7:15389
PMID: 29133887 -
Yang et al.
(2017)
Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
Cell.
169:243
PMID: 28388409 -
Chan et al.
(2016)
ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of Ins signaling in an Alzheimer's disease mouse model.
Cell.
6:26119
PMID: 27189808 -
Avanzato et al.
(2016)
Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling
Scientific Reports.
6:32602
PMID: 27586846 -
Pattabiraman et al.
(2016)
Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability.
Science.
351:aad3680
PMID: 26941323 -
Havekes et al.
(2016)
Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
J Neurosci.
36:8936
PMID: 27559174 -
Aguileta et al.
(2016)
A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress.
Cell Death Differ.
23:1670
PMID: 27341185 -
Brzosko et al.
(2015)
Retroactive modulation of spike timing-dependent plasticity by DA.
Elife.
4
PMID: 26516682 -
Elliott et al.
(2015)
Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
Am J Physiol Endocrinol Metab.
308:E130
PMID: 25406263 -
Muñoz-Llancao et al.
(2015)
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
Biochim Biophys Acta.
35:11315
PMID: 26269639 -
Parnell et al.
(2015)
Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
Mol Metab.
1853:1749
PMID: 25913012 -
Li et al.
(2015)
Increased biogenesis of glucagon-containing secretory granules and glucagon secretion in BIG3-knockout mice.
Mol Pharmacol.
4:246
PMID: 25737957 -
Emery et al.
(2015)
Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological Signaling through a Secr. Family Gs-Coupled G Protein-Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform.
J Cell Mol Med.
87:928
PMID: 25769305 -
Jansen et al.
(2015)
Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
Stem Cell Reports.
19:210
PMID: 25266063 -
Cooke et al.
(2015)
Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
Cell Death Dis.
172:593
PMID: 24697554 -
Baron et al.
(2015)
The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
Sci Rep.
6:e1629
PMID: 25654762 -
Ang et al.
(2015)
The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes.
Ann Clin Transl Neurol.
5:8134
PMID: 25633224 -
Walker et al.
(2015)
A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.
Nat Commun.
2:595
PMID: 26125036 -
Siuda et al.
(2015)
Optodynamic simulation of β-adrenergic receptor signalling.
Eneuro.
6:8480
PMID: 26412387 -
Polito et al.
(2015)
Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
J Neurosci.
2
PMID: 26465004 -
Zhu et al.
(2015)
Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
Pharmacol Res Perspect.
35:621
PMID: 25589756 -
Presley et al.
(2015)
Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
Biochem Pharmacol.
3:e00159
PMID: 26196013 -
Brust et al.
(2015)
New functional activity of aripipr. revealed: Robust antagonism of D2 DA receptor-stimulated Gβγ signaling.
Cell Rep.
93:85
PMID: 25449598 -
Ben-Simon et al.
(2015)
A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
Pflugers Arch.
12:396
PMID: 26166572 -
Broadbent et al.
(2015)
The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.
Sci Rep.
467:1783
PMID: 25277268 -
Belgacem and Borodinsky
(2015)
Inversion of Sonic hedgehog action on its canonical pathway by electrical activity.
Eur J Neurosci.
112:4140
PMID: 25829542 -
Moon et al.
(2015)
Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.
J Biol Chem.
290:11246
PMID: 25762723 -
Muthusamy et al.
(2014)
A method to identify and isolate pluripotent human stem cells and mouse epiblast stem cells using lipid body-associated retinyl ester fluorescence.
Stem Cell Reports.
3:169
PMID: 25068130 -
Adelfinger et al.
(2014)
GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization.
Biochem Pharmacol.
91:369
PMID: 25065880 -
Waheed et al.
(2014)
Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner.
Br J Pharmacol.
171:2659
PMID: 24116661 -
Chou et al.
(2014)
Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells.
PLoS One.
9:e99432
PMID: 24918932 -
Vandame et al.
(2014)
The spatio-temporal dynamics of PKA activity profile during mitosis and its correlation to chromosome segregation.
Cell Cycle.
13:3232
PMID: 25485503 -
Shelton et al.
(2014)
Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells.
Br J Pharmacol.
3:516
PMID: 25241748 -
Felizola et al.
(2014)
PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
Glia.
52:159
PMID: 24403568 -
Yang et al.
(2014)
PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.
J Biol Chem.
66:83
PMID: 24225179 -
Jia et al.
(2013)
Age-dependent regulation of synaptic connections by DA D2 receptors.
Nat Neurosci.
16:1627
PMID: 24121738 -
Pale et al.
(2013)
Cyclic AMP stimulates neurite outgrowth of lamprey reticulospinal neurons without substantially altering their biophysical properties.
Neuroscience.
245:74
PMID: 23603516 -
Wiseman et al.
(2013)
Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.
J Biol Chem.
288:17803
PMID: 23640883 -
Ehrlich et al.
(2013)
Prostaglandin E receptor EP1 forms a complex with DA D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.
Mol Pharmacol.
84:476
PMID: 23842570 -
Sohn et al.
(2013)
Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
J Mol Endocrinol.
152:612
PMID: 23374353 -
Tao et al.
(2013)
cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia.
Br J Pharmacol.
8:e71441
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Lee et al.
(2012)
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Nature.
492:123
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Mitra et al.
(2012)
Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity.
Nat Neurosci.
15:250
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Korboukh et al.
(2012)
Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.
J Med Chem.
55:6467
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Tran et al.
(2012)
Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors.
Assay Drug Dev Technol.
10:37
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Bolognini et al.
(2012)
AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.
Br J Pharmacol.
165:2561
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Hook et al.
(2012)
DArgic modulation of ganglion-cell photoreceptors in rat.
J Neurosci.
35:507
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Kaufman et al.
(2012)
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
J Neurosci.
32:3992
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Horváth et al.
(2012)
A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury.
J Neurosci.
165:2462
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Chen et al.
(2011)
Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium.
J Biol Chem.
286:13502
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Benito et al.
(2011)
cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression.
J Neurosci.
31:18237
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Althaus et al.
(2011)
Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells.
Am J Respir Cell Mol Biol.
44:53
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Garavaglia et al.
(2010)
Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
BMC Neurosci.
11:7
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Buznikov et al.
(2010)
A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
Dev Neurosci.
32:1
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Schapitz et al.
(2010)
Neuroligin 1 is dynamically exchanged at postsynaptic sites.
J Neurosci.
30:12733
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Goffin et al.
(2010)
DA-dependent tuning of striatal inhibitory synaptogenesis.
PLoS One.
30:2935
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Bonetti and Surace
(2010)
Mouse embryonic retina delivers information controlling cortical neurogenesis.
J Mol Cell Cardiol.
5:e15211
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Roscioni et al.
(2009)
PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells.
Respir Res.
10:88
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Byrnes et al.
(2009)
Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity.
J Clin Invest.
57:550
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Rao et al.
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Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.
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Identification of a novel human eicosanoid receptor coupled to G(i/o).
J Biol Chem.
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There are no citations that match your criteria.
Customer Reviews for Forskolin (6)
Customer Images
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Species: HumanAssay Type: In VitroCell Line/Tissue: Liver organoidsCulturing liver organoids - used to swell the organoids
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Species: HumanAssay Type: In VitroCell Line/Tissue: JurkatJurkat cells were treated with different concentration of Forskolin for 15 minutes and the cAMP was measured (the cAMP levels are reversely correlated with Luminescent values.)
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Species: RatAssay Type: In VitroCell Line/Tissue: Sprague-Dawley rats primary neuronal10 μM for 30min
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Species: MouseAssay Type: In VitroCell Line/Tissue: ipsTo start reprogramming, cultures were switched to reprogramming medium (ES medium supplemented with 10 mM Parnate, 3 mM Chir99021, 1 mM A83-01, and 10 mM Forskolin)
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Species: HumanAssay Type: In VitroCell Line/Tissue: HEK293HEK293 cells transfected with cAMP FRET sensor, Epac-S(H187) were perfused in normal tyrode solution and excited alternately at 430 nm and fluorescence was captured at 470 and 535 nm. Forskolin (10 µM) was added at 1 min to activate adenylyl cyclase and increase intracellular cAMP, which is detected as an increase in 470/535 fluorescence ratio.
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Species: RatForskolin activates adenylyl cyclase and increases intracellular cAMP. We used at 10 microM in cultured astrocytes to increase intracellular cAMP level.
There are no reviews that match your criteria.