Forskolin

Tocris Bioscience, part of Bio-Techne | Catalog # 1099

Adenylyl cyclase activator
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Key Product Details

Description

Adenylyl cyclase activator

Alternative Names

Coleonol,Colforsin

View all Adenylyl Cyclase Activators »

Product Description

Forskolin, or coleonol, is a cell-permeable, potent, reversible and rapid activator of adenylyl cyclase, an enzyme that converts ATP to cAMP and pyrophosphate (EC50 = 0.5 μM). In combination with other compounds, forskolin enables chemical reprogramming of mouse embryonic fibroblasts to pluripotent stem cells, without genetic factors (protocol available). In combination with IBMX (Cat. No. 2845), forskolin induces neural differentiation of mesenchymal stem cells by downregulating neuron restrictive silencer factor. In a rat model of Huntington's disease-like neurodegeneration, forskolin also exhibits neuroprotective effects. Hypotensive and vasodilatory agent.

Water-soluble analog, NKH 477 (Cat. No. 1603), and Forskolin synthesized to Ancillary Material Grade also available.

For more information about how Forskolin may be used, see our protocols: Transdifferentiating Fibroblasts into Neurons, Reprogramming Mouse Embryonic Fibroblasts (MEFs) into Skeletal Muscle Progenitors, Highly Efficient Generation of Chemically Induced Pluripotent Stem Cells (CiPSCs) from Mouse Embryonic Fibroblasts (MEFs).

Scientific Data Images for Forskolin

Adult Stem Cell-derived Liver Organoids

Application of Forskolin in Culture and Characterization of Adult Stem Cell-derived Liver Organoids.

Adult stem cell-derived liver organoids were cultured using Forskolin, Y-27632 dihydrochloride (Catalog # 1254), HEPES (Catalog # 3173), A 83-01 (Catalog # 2939), N-Acetylcysteine (Catalog # 7874), along with other reagents used in the human liver organoid culture protocol. After 3 days, liver organoid expansion medium was added for 7-10 days, followed by liver organoid differentiation medium, which includes HEPES (Catalog # 3173), Nicotinamide (Catalog # 4106), N-Acetylcysteine (Catalog # 7874), A 83-01 (Catalog # 2939), along with other reagents. Differentiated human liver organoids were stained using a (A) Human Serum Albumin Antibody (Catalog # MAB1455; red) and a (B) Human HNF-3 beta /FoxA2 Antibody (Catalog # AF2400; red) and counterstained with DAPI (Catalog # 5748; blue).

Product Specifications

Molecular Weight

410.51

Formula

C22H34O7

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one

CAS Number

66575-29-9

PubChem ID

47936

InChI Key

OHCQJHSOBUTRHG-KGGHGJDLSA-N

SMILES

C=C[C@](C3)(C)O[C@]2(C)[C@@H](OC(C)=O)[C@@H](O)[C@@]1([H])C(C)(C)CC[C@H](O)[C@@](C)1[C@](O)2C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.26 25
Ethanol 4.11 10

Preparing Stock Solutions for Forskolin

The following data is based on the product molecular weight 410.51

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.74 mL 48.72 mL 97.44 mL
1.25 mM 1.95 mL 9.74 mL 19.49 mL
2.5 mM 0.97 mL 4.87 mL 9.74 mL
12.5 mM 0.19 mL 0.97 mL 1.95 mL

Calculators

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Reconstitution Calculator

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Product Documents for Forskolin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Forskolin

For research use only

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