SB 202190

Name: SB 202190
Brand: Tocris Bioscience
SKU: 1264
Rating: 3 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1264

Citations (36)

(1)

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Key Product Details

Description:	Potent, selective inhibitor of p38 MAPK
Chemical Name:	4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
Purity:	≥99% (HPLC)
Molecular Weight:	331.35

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Biological Activity for SB 202190

SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (K_d = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC₅₀ = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Inhibits Yamanaka factor reprogramming of human fibroblasts to iPSCs. SB 202190 improves the self-renewal ability of neuronal stem cells from NPC1-deficient mice.

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries for SB 202190

SB 202190 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 202190

M. Wt	331.35
Formula	C₂₀H₁₄N₃OF
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	152121-30-7
PubChem ID	16759148
InChi Key	YKRNPHOBDOUQTG-UHFFFAOYSA-N
Smiles	OC1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 202190

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.13	100

Preparing Stock Solutions for SB 202190

The following data is based on the product molecular weight 331.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.09 mL	30.18 mL
5 mM	0.60 mL	3.02 mL	6.04 mL
10 mM	0.30 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for SB 202190

References are publications that support the biological activity of the product.

Neganova A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs. Sci.Rep. 2017 PMID: 28155868
Sato SnapShot: Growing Organoids from Stem Cells. Cell 2015 PMID: 26091044
Bartfeld In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 2015 PMID: 25307862
Karthaus Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell 2014 PMID: 25201529
Gafni Derivation of novel human ground state naive pluripotent stem cells. Nature 2013 PMID: 24172903
Sato Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology 2011 PMID: 21889923
Yang NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling. Stem Cells 2006 PMID: 16099992
Davies Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 2000 PMID: 10998351
Frantz The activation of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding. Biochemistry 1998 PMID: 9753474
Nemoto Induction of apoptosis by SB 202190 through inhibition of p38β mitogen-activated protein kinase. J.Biol.Chem. 1998 PMID: 9632706
Jiang Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). J.Biol.Chem. 1996 PMID: 8663524

Citations for SB 202190 (36)

Showing 1 - 10 of 36 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SB 202190 include:

Schiff et al. (2019) P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy. Commun Biol. 2:162
PMID: 31069271
Ranganathan et al. (2019) Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model. Infect Immun. 87
PMID: 30642900
Kang et al. (2018) Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys. Cell Rep. 25:2563
PMID: 30485820
Nadeem (2017) IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression. Cytokine. 97:14
PMID: 28570931
Zhou (2017) TNFα induces tolerant production of CXC chemokines in colorectal cancer HCT116 cells via A20 inhibition of ERK signaling. Int Immunopharmacol. 54(296)
PMID: 29175508
Pervolaraki et al. (2017) Type I and Type III IF.s Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut. Front Immunol. 8:459
PMID: 28484457
Molina et al. (2017) p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation. Development. 144:2270
PMID: 28507001
Wong et al. (2016) Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK. J Neuroinflammation. 13:251
PMID: 27663973
Zhang et al. (2015) Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia. PLoS One. 5:16548
PMID: 26549644
Oliveira et al. (2015) The role of Na+/K+-ATPase during chick skeletal myogenesis. J Neurosci. 10:e0120940
PMID: 25775465
Page et al. (2015) Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II. Biomaterials. 64:33
PMID: 26115412
Tichet et al. (2015) Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis. Nat Commun. 6:6993
PMID: 25925867
Toutounchian et al. (2014) Modulation of radiation injury response in retinal endothelial cells by quinic acid derivative KZ-41 involves p38 MAPK. PLoS One. 9:e100210
PMID: 24956278
Babu et al. (2014) TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer. 14:113
PMID: 24555435
Nicastro et al. (2013) 3,3'-diindolylmethane rapidly and selectively inhibits hepatocyte growth factor/c-Met signaling in breast cancer cells. J Nutr Biochem. 24:1882
PMID: 23968581
Xia et al. (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 14:638
PMID: 23792643
Kleinewietfeld et al. (2013) Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Sci Rep. 496:518
PMID: 23467095
Morse et al. (2013) Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol. 14:17
PMID: 23497702
Akhmetshina et al. (2012) Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. J Biol Chem. 3:735
PMID: 22415826
Zhu et al. (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. Am J Physiol Lung Cell Mol Physiol. 31:31
PMID: 22463935
Shaw and Lloyd (2012) Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide. Nature. 84:155
PMID: 22683469
Turpeinen et al. (2011) Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase. J Neurosci. 2011:127587
PMID: 21547253
Medici et al. (2011) Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling. J Exp Clin Cancer Res. 437:515
PMID: 21585337
Ye et al. (2011) Dermatophagoides pteronyssinus 2 regulates nerve growth factor release to induce airway inflammation via a reactive oxygen species-dependent pathway. Am J Physiol Regul Integr Comp Physiol. 300:L216
PMID: 21097523
Morse et al. (2011) Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target. PLoS One. 6:e25643
PMID: 22003401
Makhortova et al. (2011) A screen for regulators of survival of motor neuron protein levels. Nat Chem Biol. 7:544
PMID: 21685895
Wong et al. (2010) Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circ Res. 107:984
PMID: 20724703
Riedl et al. (2009) Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. Nat Commun. 29:13377
PMID: 19846725
Doulatov et al. (2009) PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes Dev. 23:2076
PMID: 19723763
Guillemot and Citi (2006) Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA. Mol Biol Cell. 17:3569
PMID: 16723500
Rajnicek et al. (2006) Temporally and spatially coordinated roles for Rho, Rac, Cdc42 and their effectors in growth cone guidance by a physiological electric field. J Cell Sci. 119:1723
PMID: 16595546
Ma et al. (2005) Oxygen-sensitive {δ}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection. Mediators Inflamm. 280:16208
PMID: 15687501
Bellik et al. (2005) Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia. Br J Pharmacol. 146:568
PMID: 16086034
Montero et al. (2004) Calcineurin-independent inhibition of mitochondrial Ca²⁺ uptake by cyclosporin A. Br J Pharmacol. 141:263
PMID: 14691054
Gallagher et al. (2004) Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1. Biochem J. 24:4859
PMID: 15152046
Atherton et al. (2003) IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol. 285:L730
PMID: 12794003

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Works, but don't store 6 months greater

Name: Scott Scarneo

Species: Human

Assay Type: Ex Vivo

Cell Line/Tissue: MDA-231

Stored ok, seemed to lose potency over time at -20 aliquots.

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