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NFkB/IkB Inhibitors: Small Molecules and Peptides
NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.
34 results for "NFkB/IkB Inhibitors Small Molecules and Peptides" in Products
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NFkB/IkB Inhibitors: Small Molecules and Peptides
NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.
34 results for "NFkB/IkB Inhibitors Small Molecules and Peptides" in Products
Proteasome and calpain inhibitor. Inhibits NF-κB activation
| Alternate Names : | Z-LLL-al, Z-Leu-Leu-Leu-CHO |
| Chemical Name : | N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
| Purity : | ≥95% (HPLC) |
Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
| Alternate Names : | Bay 11-7083 |
| Chemical Name : | (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile |
| Purity : | ≥99% (HPLC) |
RAGE antagonist
| Purity : | ≥95% (HPLC) |
Inhibits TNF-induced NF-κB activation
| Chemical Name : | 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol |
| Purity : | ≥98% (HPLC) |
NF-κB and AP-1 dual inhibitor
| Chemical Name : | N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
| Purity : | ≥99% (HPLC) |
Selective inhibitor of TBK
| Chemical Name : | 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid |
| Purity : | ≥99% (HPLC) |
Inhibitor of NF-κB activation; anti-inflammatory
| Chemical Name : | (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one |
| Purity : | ≥98% (HPLC) |
Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation
| Alternate Names : | (-)-Arctigenin |
| Chemical Name : | (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone |
| Purity : | ≥98% (HPLC) |
Anti-inflammatory, antioxidant and free radical scavenger
| Alternate Names : | 3',4',5,7-Tetrahydroxyflavone |
| Chemical Name : | 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one |
| Purity : | ≥98% (HPLC) |
Specific inhibitor of NF-κB activation
| Alternate Names : | CAPE |
| Chemical Name : | 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester |
| Purity : | ≥98% (HPLC) |
Catalog #:
5699
Potent Nurr1 activator
| Chemical Name : | 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one |
| Purity : | ≥98% (HPLC) |
Catalog #:
6829
PTEN inhibitor; induces necroptosis; anti-inflammatory
| Chemical Name : | 5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione |
| Purity : | ≥98% (HPLC) |
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
| Chemical Name : | (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one |
| Purity : | ≥98% (HPLC) |
E2 ubiquitin (Ub) conjugating enzymes inhibitor
| Alternate Names : | Bay 11-7082 |
| Chemical Name : | (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile |
| Purity : | ≥99% (HPLC) |
Novel IKK2-selective inhibitor
| Chemical Name : | N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride |
| Purity : | ≥98% (HPLC) |
Selective allosteric inhibitor of IKK; anti-inflammatory
| Chemical Name : | N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride |
| Purity : | ≥99% (HPLC) |
Selective inhibitor of IKK
| Chemical Name : | N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride |
| Purity : | ≥98% (HPLC) |
Catalog #:
4354
Inhibits NOD1-induced NF-κB activation
| Chemical Name : | 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine |
| Purity : | ≥99% (HPLC) |
Inhibitor of IKKβ; also exhibits antibacterial activity
| Chemical Name : | N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide |
| Purity : | ≥99% (HPLC) |
Inhibits TNF-α-induced NF-κB activation
| Chemical Name : | (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid |
| Purity : | ≥99% (HPLC) |
Catalog #:
5821
Nurr1 activator; inhibits NF-κB-dependent gene expression
| Chemical Name : | 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole] |
| Purity : | ≥98% (HPLC) |
IKKβ inhibitor; attenuates NF-κB-induced gene expression
| Chemical Name : | 4-Amino-[2',3'-bithiophene]-5-carboxamide |
| Purity : | ≥98% (HPLC) |
Catalog #:
5672
Potent and selective IKKε inhibitor
| Chemical Name : | 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile |
| Purity : | ≥98% (HPLC) |
Catalog #:
6646
Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ
| Chemical Name : | 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester |
Blocks NF-κB activation; also anti-inflammatory and antioxidant
| Chemical Name : | 5,3'-Diallyl-2,4'-dihydroxybiphenyl |
| Purity : | ≥98% (HPLC) |
