BMS 345541

Name: BMS 345541
Brand: Tocris Bioscience
SKU: 4806
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4806

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Citations (15)

COA / SDS

Selective allosteric inhibitor of IKK; anti-inflammatory

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Technical Data
Citations & Reviews

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective allosteric inhibitor of IKK; anti-inflammatory

View all IkB Kinase Inhibitors »

Product Description

BMS 345541 is a selective allosteric inhibitor of IKK (IC₅₀ values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

Product Specifications

Molecular Weight

291.78

Formula

C₁₄H₁₇N₅.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N¹-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride

CAS Number

547757-23-3

PubChem ID

9926054

InChI Key

MIDKPVLYXNLFGZ-UHFFFAOYSA-N

SMILES

NCCNC1=NC3=C(C=C(C)C=C3)N2C1=NC=C2C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	29.18	100
	DMSO	29.18	100

Preparing Stock Solutions for BMS 345541

The following data is based on the product molecular weight 291.78

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.43 mL	17.14 mL	34.27 mL
5 mM	0.69 mL	3.43 mL	6.85 mL
10 mM	0.34 mL	1.71 mL	3.43 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Burke BMS-345541 is a highly selective inhibitor of IκB kinase that binds at an allosteric site of the enzyme and blocks NF- κB-dependent transcription in mice. J.Biol.Chem. 2003 PMID: 12403772
De Silva Inhibition of choriodecidual cytokine production and inflammatory gene expression by selective IκB kinase (IKK) inhibitors. Br.J.Pharmacol. 2010 PMID: 20649582
Pattoli Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IκB kinase through suppression of metalloproteinase expression. J.Pharmacol.Exp.Ther. 2005 PMID: 16009742