BMS 345541

Name: BMS 345541
Brand: Tocris Bioscience
SKU: 4806
Rating: 5 (2 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4806

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(2)

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Key Product Details

Description:	Selective allosteric inhibitor of IKK; anti-inflammatory
Chemical Name:	N¹-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	291.78

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Biological Activity for BMS 345541

BMS 345541 is a selective allosteric inhibitor of IKK (IC₅₀ values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

Compound Libraries for BMS 345541

BMS 345541 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BMS 345541

M. Wt	291.78
Formula	C₁₄H₁₇N₅.HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	547757-23-3
PubChem ID	9926054
InChi Key	MIDKPVLYXNLFGZ-UHFFFAOYSA-N
Smiles	NCCNC1=NC3=C(C=C(C)C=C3)N2C1=NC=C2C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 345541

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	29.18	100
	DMSO	29.18	100

Preparing Stock Solutions for BMS 345541

The following data is based on the product molecular weight 291.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.43 mL	17.14 mL	34.27 mL
5 mM	0.69 mL	3.43 mL	6.85 mL
10 mM	0.34 mL	1.71 mL	3.43 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

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References for BMS 345541

References are publications that support the biological activity of the product.

De Silva Inhibition of choriodecidual cytokine production and inflammatory gene expression by selective IκB kinase (IKK) inhibitors. Br.J.Pharmacol. 2010 PMID: 20649582
Pattoli Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IκB kinase through suppression of metalloproteinase expression. J.Pharmacol.Exp.Ther. 2005 PMID: 16009742
Burke BMS-345541 is a highly selective inhibitor of IκB kinase that binds at an allosteric site of the enzyme and blocks NF- κB-dependent transcription in mice. J.Biol.Chem. 2003 PMID: 12403772

Citations for BMS 345541 (1)

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Citations are publications that use Bio-Techne products. Selected citations for BMS 345541 include:

Reho et al. (2019) Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species. J Am Heart Assoc. 8:e010662
PMID: 31020916

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Customer Reviews for BMS 345541 (2)

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BMS 345541 (Cat. No. 4806) in 3 D cultures

Name: Clara Lubeseder-Martellato

Species: Mouse

Assay Type: Ex Vivo

Cell Line/Tissue: Acini

BMS 345541 was added to pancreatic acinar 3-dimensional cultures and differentiation of the cultures was monitored for 3 to 4 days. The concentration ranged between 1 and 10 uM.
Great, easy to store

Name: Brian Englar

Species: Human

Assay Type: Ex Vivo

Cell Line/Tissue: MDA-231

This IKK inhibitor worked in our evaluation of TAK1 in MDA-231 cells. We compared the ability of this inhibitor to induce TNf mediated death to a TAK1 inhibitor.

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Product Documents for BMS 345541

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.