Key Product Details
Description: | Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive |
Chemical Name: | (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 360.4 |
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Citations for Triptolide (7)
Citations are publications that use Bio-Techne products. Selected citations for Triptolide include:
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Shao et al.
(2019)
Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing.
Elife.
8
PMID: 31021316 -
Tettey et al.
(2019)
A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing.
Cell Rep.
27:3770
PMID: 31242411 -
Bowry et al.
(2018)
BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication.
Cell Rep.
25:2061
PMID: 30463005 -
Liao and Mizzen
(2017)
Site-specific regulation of histone H1 phosphorylation in pluripotent cell differentiation.
Epigenetics Chromatin.
10:29
PMID: 28539972 -
Zhao et al.
(2015)
Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.
Sci Rep.
5:7647
PMID: 25558795 -
Filone et al.
(2014)
The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.
PLoS Pathog.
10:e1003904
PMID: 24516381 -
Vollmer et al.
(2012)
Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1).
J Biol Chem.
287:35212
PMID: 22898817
There are no citations that match your criteria.
Customer Reviews for Triptolide (1)
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Species: HumanAssay Type: In VitroCell Line/Tissue: U2OStriptolide (1 μM)I used short treatments with the transcription inhibitors triptolide. These inhibited ongoing RNA synthesis and increased replication fork speeds specifically in the presence of JQ1
There are no reviews that match your criteria.