Triptolide

Product Description

Triptolide inhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC₅₀ = 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Triptolide blocks RNA synthesis in HeLa cells (IC₅₀ = 62 nM); exhibits potent antiproliferative activity in 60 cancer cell lines (average IC₅₀ = 12 nM) and induces apoptosis by blocking TNF-α-mediated c-IAP1 and c-IAP2 induction. Also displays immunosuppressive and anti-inflammatory activity.

Solubility

Preparing Stock Solutions for Triptolide

The following data is based on the product molecular weight 360.40

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.87 mL	69.37 mL	138.73 mL
1 mM	2.77 mL	13.87 mL	27.75 mL
2 mM	1.39 mL	6.94 mL	13.87 mL
10 mM	0.28 mL	1.39 mL	2.77 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lee PG490 (Triptolide) cooperates with tumor necrosis factor-α to induce apoptosis in tumor cells. J.Biol.Chem. 1999 PMID: 10224110
• Titov XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat.Chem.Biol. 2011 PMID: 21278739
• Qui Immunosuppressant PG490 (Triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-κB transcriptional activation. J.Biol.Chem. 1999 PMID: 10224109