NFkB/IkB Inhibitors

Irreversible inhibitor of TNF-α-induced IκBα phosphorylation

Proteasome and calpain inhibitor. Inhibits NF-κB activation

Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation

Potent, selective inhibitor of IKKβ

Novel IKK2-selective inhibitor

NF-κB and AP-1 dual inhibitor

Specific inhibitor of NF-κB activation

Selective IKKα and IKKβ inhibitor

Selective inhibitor of IKK

Inhibits TNF-α-induced NF-κB activation

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1

Potent farnesyl diphosphate (FPP) synthase inhibitor

Selective allosteric inhibitor of IKK; anti-inflammatory

High affinity antagonist of RAGE

Inhibitor of IKKβ; also exhibits antibacterial activity

Anti-inflammatory, antioxidant and free radical scavenger

Potent and selective IKKβ inhibitor

Selective inhibitor of TBK

Potent Nurr1 activator

Potent and selective IKKε inhibitor

Nurr1 activator; inhibits NF-κB-dependent gene expression

Potent NIK inhibitor

TRAF6-Ubc13 interaction inhibitor