Skip to main content

NFkB/IkB Inhibitors Products

NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.

Show More

31 results for "NFkB/IkB Inhibitors" in Products

NFkB/IkB Inhibitors Products

NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.

Show More

31 results for "NFkB/IkB Inhibitors" in Products

Proteasome and calpain inhibitor. Inhibits NF-κB activation

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1

Potent, selective inhibitor of IKKβ

Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation

Potent farnesyl diphosphate (FPP) synthase inhibitor

E2 ubiquitin (Ub) conjugating enzymes inhibitor

Inhibits TNF-induced NF-κB activation

Irreversible inhibitor of TNF-α-induced IκBα phosphorylation

Specific inhibitor of NF-κB activation

NF-κB and AP-1 dual inhibitor

Selective IKKα and IKKβ inhibitor

Selective allosteric inhibitor of IKK; anti-inflammatory

Selective inhibitor of TBK

IKKβ inhibitor; attenuates NF-κB-induced gene expression

Selective inhibitor of IKK

Inhibitor of NF-κB activation; anti-inflammatory

Inhibits NF-κB activation

Novel IKK2-selective inhibitor

Inhibitor of IKKβ; also exhibits antibacterial activity

Potent and selective IKKβ inhibitor

Inhibits TNF-α-induced NF-κB activation

Blocks NF-κB activation; also anti-inflammatory and antioxidant

Potent and selective IKKε inhibitor

RAGE antagonist

Results Per Page
5 10 25 50
/ 2