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NFkB/IkB Inhibitors Products

NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.

34 results for "NFkB/IkB Inhibitors" in Products

NFkB/IkB Inhibitors Products

NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.

34 results for "NFkB/IkB Inhibitors" in Products

Proteasome and calpain inhibitor. Inhibits NF-κB activation

Irreversible inhibitor of TNF-α-induced IκBα phosphorylation

RAGE antagonist

Inhibits TNF-induced NF-κB activation

NF-κB and AP-1 dual inhibitor

Selective inhibitor of TBK

Inhibitor of NF-κB activation; anti-inflammatory

Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation

Anti-inflammatory, antioxidant and free radical scavenger

Specific inhibitor of NF-κB activation

Potent Nurr1 activator

PTEN inhibitor; induces necroptosis; anti-inflammatory

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

E2 ubiquitin (Ub) conjugating enzymes inhibitor

Novel IKK2-selective inhibitor

Selective allosteric inhibitor of IKK; anti-inflammatory

Selective inhibitor of IKK

Inhibits NOD1-induced NF-κB activation

Inhibitor of IKKβ; also exhibits antibacterial activity

Inhibits TNF-α-induced NF-κB activation

Nurr1 activator; inhibits NF-κB-dependent gene expression

IKKβ inhibitor; attenuates NF-κB-induced gene expression

Potent and selective IKKε inhibitor

Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ

Blocks NF-κB activation; also anti-inflammatory and antioxidant

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