Arctigenin

Name: Arctigenin
Brand: tocris
SKU: 1777

Catalog # 1777

Citations (2)

Datasheet / COA / SDS

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Key Product Details

Description:	Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation
Alternative Names:	(-)-Arctigenin
Chemical Name:	(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
Purity:	≥98% (HPLC)
Molecular Weight:	372.42

View Full Technical Details for Arctigenin

Biological Activity

Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC₅₀ = 10 nM). Inhibits HIV-1 replication in vitro. Also potently inhibits MKK1 (MEK1) (IC₅₀ = 0.5 nM) and provides neuroprotection by binding to kainate receptors.

Compound Libraries

Arctigenin is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	372.42
Formula	C₂₁H₂₄O₆
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	7770-78-7
PubChem ID	64981
InChi Key	NQWVSMVXKMHKTF-JKSUJKDBSA-N
Smiles	OC(C=C3)=C(OC)C=C3C[C@@H](C(OC2)=O)[C@H]2CC1=CC(OC)=C(OC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	9.31	25 with gentle warming
	DMSO	37.24	100

Preparing Stock Solutions

The following data is based on the product molecular weight 372.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.43 mL	26.85 mL
5 mM	0.54 mL	2.69 mL	5.37 mL
10 mM	0.27 mL	1.34 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References

References are publications that support the biological activity of the product.

Cho Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation. Int.Immunopharmacol. 2002 PMID: 11789661
Jang Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor. J.Neurosci.Res. 2002 PMID: 11948668
Schroder Differential in vitro anti-HIV activity of natural lignans. Z.Naturforsch.C. 1990 PMID: 1965681
Cho Arctigenin, a potent inhibitor of MKK1, inhibits lipopolysaccharide (LPS)-inducible nitric oxide synthase expression through inhibition of I-κBα phosphorylation and of p65 nuclear translocation. Exp.Biol.Abstr.

Citations (2)

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Citations are publications that use Bio-Techne products. Selected citations for Arctigenin include:

Rycaj et al. (2016) Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells. Oncotarget. 7:14220
PMID: 26871947
Ogungbe et al. (2014) (-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β. J Chem Inf Model. 54:3051
PMID: 25383984

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Product Documents

COA

Certificate of Analysis

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Arctigenin

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References

Citations (2)

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