Celastrol
Tocris Bioscience, part of Bio-Techne | Catalog # 3203
Inhibits TNF-α-induced NF-κB activation
Key Product Details
Description
Inhibits TNF-α-induced NF-κB activation
Product Description
Celastrol is an antioxidant, anti-inflammatory, antitumor and neuroprotective agent. Inhibits lipid peroxidation in mitochondria, TNF-α-induced NFκB activation, peroxidase activity of peroxiredoxin 1 (IC50 = 0.29 μM), and topoisomerase II activity in vitro (IC50 = 7.41 μM). Celastrol treatment inhibits the growth of PC-3 tumors in mice.Product Specifications
Molecular Weight
450.61
Formula
C29H38O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
CAS Number
34157-83-0
PubChem ID
122724
InChI Key
KQJSQWZMSAGSHN-JJWQIEBTSA-N
SMILES
O=C2C(O)=C(C)C1=CC=C([C@](CC[C@]5(C)[C@]([H])4C[C@](C)([C@@](O)=O)CC5)(C)[C@@]4(C)CC3)[C@]3(C)C1=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.06 | 100 | |
| Ethanol | 33.8 | 75 |
Preparing Stock Solutions
for Celastrol
The following data is based on the product molecular weight 450.61
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.10 mL | 22.19 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.44 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yang Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 PMID: 16651429
- Xu Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal Transduct.Target Ther. 2023 PMID: 36732502
- Sethi Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood 2007 PMID: 17110449
- Sassa The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem.Biophys.Res.Comms. 1990 PMID: 2241977
- Nagase Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci.Biotechnol.Biochem. 2003 PMID: 14519971
Product Specific Notices for Celastrol
For research use only
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