Amlexanox

Product Description

Amlexanox is a selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε (IC₅₀ values are ~1-2 μM). Displays no effect on IKKα or IKKβ at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro.

Solubility

Preparing Stock Solutions for Amlexanox

The following data is based on the product molecular weight 298.29

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.35 mL	16.76 mL	33.52 mL
5 mM	0.67 mL	3.35 mL	6.70 mL
10 mM	0.34 mL	1.68 mL	3.35 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Okada Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amle. Biochem.J. 2003 PMID: 12803546
• Makino Mechanism of action of an antiallergic agent, amle. (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase. Int.Arch.Allergy Appl.Immunol. 1987 PMID: 2433225
• Reilly An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice. Nat.Med. 2012 PMID: 23396211