IP7e
Tocris Bioscience, part of Bio-Techne | Catalog # 5699
Potent Nurr1 activator
Key Product Details
Description
Potent Nurr1 activator
Product Description
IP7e is a potent Nurr1 activator (EC50 = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.Product Specifications
Molecular Weight
390.43
Formula
C23H22N2O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one
CAS Number
500164-74-9
PubChem ID
9908426
InChI Key
YCAACZFPADQMAR-UHFFFAOYSA-N
SMILES
CN1C(C2=CC=C(COCCOC)C=C2)=CC3=C(C(C4=CC=CC=C4)=NO3)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.04 | 100 | |
| Ethanol | 7.81 | 20 with gentle warming |
Preparing Stock Solutions
for IP7e
The following data is based on the product molecular weight 390.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.56 mL | 12.81 mL | 25.61 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Montarolo Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One 2014 PMID: 25265488
- Hintermann Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg.Med.Chem.Lett. 2007 PMID: 17035009
Product Specific Notices for IP7e
For research use only
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