Caffeic acid phenethyl ester

Name: Caffeic acid phenethyl ester
Brand: tocris
SKU: 2743

Catalog # 2743

Citations (11)

Datasheet / COA / SDS

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Key Product Details

Description:	Specific inhibitor of NF-κB activation
Alternative Names:	CAPE
Chemical Name:	3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	284.31

View Full Technical Details for Caffeic acid phenethyl ester

Biological Activity

Caffeic acid phenethyl ester is an antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF-κB activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.

Technical Data

M. Wt	284.31
Formula	C₁₇H₁₆O₄
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	104594-70-9
PubChem ID	5281787
InChi Key	SWUARLUWKZWEBQ-VQHVLOKHSA-N
Smiles	OC1=C(O)C=C(/C=C/C(OCCC2=CC=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.43	100
	ethanol	28.43	100

Preparing Stock Solutions

The following data is based on the product molecular weight 284.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.52 mL	17.59 mL	35.17 mL
5 mM	0.70 mL	3.52 mL	7.03 mL
10 mM	0.35 mL	1.76 mL	3.52 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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References

References are publications that support the biological activity of the product.

Sud'ina Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 1993 PMID: 7689063
Fitzpatrick Caffeic acid phenethyl ester, an inhibitor of nuclear factor-κB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J.Pharmacol.Exp.Ther. 2001 PMID: 11714876
Natarajan Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB. Proc.Natl.Acad.Sci.USA

Citations (11)

Showing 1 - 10 of 11 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Caffeic acid phenethyl ester include:

Tawara et al. (2019) HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1β. Oncotarget. 10:2068
PMID: 31007849
Messerschmidt et al. (2019) Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis. 25:329
PMID: 31341381
Kleiner et al. (2018) Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 24:647
PMID: 30310263
Ciarlo et al. (2017) A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. Elife. 6
PMID: 28832322
Mia and Bank (2016) The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis. PLoS Pathog. 363:775
PMID: 26453399
Ong et al. (2015) Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis. Mol Vis. 11:e1004917
PMID: 25996154
Brosig et al. (2015) Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA. Mol Vis. 21:1000
PMID: 26330750
Hollborn et al. (2015) Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. Cell Biosci. 21:360
PMID: 25878490
Munegowda and Hu (2015) Transient blocking of NK cell function with small molecule inhibitors for helper dependant adenoviral vector-mediated gene delivery. J Exp Clin Cancer Res. 5:29
PMID: 26085921
Pysz et al. (2014) Differential regulation of cyclin D1 expression by protein kinase C α and ε signaling in intestinal epithelial cells. J Biol Chem. 289:22268
PMID: 24914206
Zhu et al. (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. Front Cell Neurosci. 31:31
PMID: 22463935

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Showing 1 - 10 of 11 citations Showing All

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COA

Certificate of Analysis

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Caffeic acid phenethyl ester

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Biological Activity

Technical Data

Solubility

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Reconstitution Calculator

References

Citations (11)

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COA

Certificate of Analysis

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