GSK 319347A
Tocris Bioscience, part of Bio-Techne | Catalog # 5672
Potent and selective IKKε inhibitor
Key Product Details
Description
Potent and selective IKKε inhibitor
Product Description
GSK 319347A is a potent and selective IKKε inhibitor (pIC50 = 7.4). Exhibits >100-fold selectivity for IKKε over IKKα IKKβ, and a range of other kinases.Product Specifications
Molecular Weight
469.53
Formula
C22H19N3O5S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile
CAS Number
862812-98-4
PubChem ID
11626927
InChI Key
LDTAHRLHGHFHKP-UHFFFAOYSA-N
SMILES
CS(C1=CC=CC=C1COC2=C(C#N)SC(N3C4=CC(OC)=C(OC)C=C4N=C3)=C2)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.95 | 100 |
Preparing Stock Solutions
for GSK 319347A
The following data is based on the product molecular weight 469.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.65 mL | 21.30 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bamborough 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase. Bioorg.Med.Chem.Lett. 2006 PMID: 16997559
Product Specific Notices for GSK 319347A
For research use only
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