Key Product Details
Description: | Potent, selective inhibitor of IKKβ |
Chemical Name: | 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide |
Purity: | ≥97% (HPLC) |
Molecular Weight: | 279.29 |
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Citations for TPCA-1 (8)
Citations are publications that use Bio-Techne products. Selected citations for TPCA-1 include:
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Betancur
(2017)
A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer.
Nat Commun.
8:14802
PMID: 28378740 -
O'Sullivan et al.
(2016)
Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions inhuman astrocytes.
Journal of Neuroinflammation.
13:189
PMID: 27549131 -
Pescatore et al.
(2016)
NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II.
Cell Death & Disease.
7:e2346
PMID: 27560715 -
Gaddipati et al.
(2015)
IKK2 Inhibition Using TPCA-1-Loaded PLGA Microparticles Attenuates Laser-Induced Choroidal Neovascularization and Macrophage Recruitment.
PLoS One.
10:e0121185
PMID: 25803615 -
Cataldi et al.
(2015)
Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1.
Virology.
485:340
PMID: 26331681 -
Yi et al.
(2014)
Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels.
J Biol Chem.
289:10853
PMID: 24570002 -
Lu et al.
(2014)
IKK2 inhibition attenuates laser-induced choroidal neovascularization.
Open Biol.
9:e87530
PMID: 24489934 -
Rauert et al.
(2011)
TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms.
Cell Death Dis.
2:e194
PMID: 21850048
There are no citations that match your criteria.