ML 120B dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4899

Novel IKK2-selective inhibitor
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Key Product Details

Description

Novel IKK2-selective inhibitor

View all IkB Kinase Inhibitors »

Product Description

ML 120B dihydrochloride is a novel, ATP-competitive IKK2-selective inhibitor (IC50 = 60 nM at 50 μM ATP). Exhibits no inhibition at IKK1 (EC50 >100 μM), IKKε (EC50 >100 μM) or a panel of 28 other kinases (EC50 >50 μM). Exhibits antitumor activity in lymphoma-bearing SCID mice. Demonstrates synergistic cytotoxic effects with vincristine (Cat. No. 1257).

Product Specifications

Molecular Weight

439.72

Formula

C19H15ClN4O2.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride

CAS Number

1782573-78-7

PubChem ID

90488985

InChI Key

AWKOVWFBTRXQLW-UHFFFAOYSA-N

SMILES

ClC1=C(OC)C(NC(C4=CC=CN=C4C)=O)=C2C(C(C=CN=C3)=C3N2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.2 5 with gentle warming
DMSO 8.79 20

Preparing Stock Solutions for ML 120B dihydrochloride

The following data is based on the product molecular weight 439.72

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.37 mL 56.85 mL 113.71 mL
1 mM 2.27 mL 11.37 mL 22.74 mL
2 mM 1.14 mL 5.69 mL 11.37 mL
10 mM 0.23 mL 1.14 mL 2.27 mL

Calculators

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Product Documents for ML 120B dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 120B dihydrochloride

For research use only

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