ML 120B dihydrochloride

Name: ML 120B dihydrochloride
Brand: Tocris Bioscience
SKU: 4899
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4899

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Key Product Details

Description:	Novel IKK2-selective inhibitor
Chemical Name:	N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	439.72

View Full Technical Details for ML 120B dihydrochloride

Biological Activity for ML 120B dihydrochloride

ML 120B dihydrochloride is a novel, ATP-competitive IKK2-selective inhibitor (IC₅₀ = 60 nM at 50 μM ATP). Exhibits no inhibition at IKK1 (EC₅₀ >100 μM), IKKε (EC₅₀ >100 μM) or a panel of 28 other kinases (EC₅₀ >50 μM). Exhibits antitumor activity in lymphoma-bearing SCID mice. Demonstrates synergistic cytotoxic effects with vincristine (Cat. No. 1257).

Compound Libraries for ML 120B dihydrochloride

ML 120B dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 120B dihydrochloride

M. Wt	439.72
Formula	C₁₉H₁₅ClN₄O₂.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1782573-78-7
PubChem ID	90488985
InChi Key	AWKOVWFBTRXQLW-UHFFFAOYSA-N
Smiles	ClC1=C(OC)C(NC(C4=CC=CN=C4C)=O)=C2C(C(C=CN=C3)=C3N2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 120B dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	8.79	20
	water	2.2	5 with gentle warming

Preparing Stock Solutions for ML 120B dihydrochloride

The following data is based on the product molecular weight 439.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.37 mL	56.85 mL	113.71 mL
1 mM	2.27 mL	11.37 mL	22.74 mL
2 mM	1.14 mL	5.69 mL	11.37 mL
10 mM	0.23 mL	1.14 mL	2.27 mL

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Reconstitution Calculator

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References for ML 120B dihydrochloride

References are publications that support the biological activity of the product.

Al-Katib I-kappa-kinase-2 (IKK-2) inhibition potentiates vincri. cytotoxicity in non-Hodgkin's lymphoma. Mol.Cancer 2010 PMID: 20809973
Catley Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol.Pharmacol. 2006 PMID: 16687566
Nagashima Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta. Blood 2006 PMID: 16439676

Citations for ML 120B dihydrochloride

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ML 120B inhibits LPS-induced TNFa expression

Name: Anonymous

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: Macrophages

RAW macrophages were incubated with 1 μM ML 120B for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with ML 120B.

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