Vincristine sulfate
Tocris Bioscience, part of Bio-Techne | Catalog # 1257
Disrupts microtubules
Product Description
Vincristine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.Product Specifications
Molecular Weight
923.04
Formula
C46H56N4O10.H2SO4
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
22-Oxovincaleukoblastine
CAS Number
2068-78-2
PubChem ID
249332
InChI Key
AQTQHPDCURKLKT-JKDPCDLQSA-N
SMILES
OS(O)(=O)=O.[H][C@@]23N(C=O)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions
for Vincristine sulfate
The following data is based on the product molecular weight 923.04
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.08 mL | 5.42 mL | 10.83 mL |
| 5 mM | 0.22 mL | 1.08 mL | 2.17 mL |
| 10 mM | 0.11 mL | 0.54 mL | 1.08 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Takano Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol.Res.Pract. 1993 PMID: 8321748
- Wang The effect of antimicrotubule agents on signal transduction pathways of apoptosis. Cancer Chemother.Pharmacol. 1999 PMID: 10501907
- Jordan Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 1985 PMID: 3986806
Product Specific Notices for Vincristine sulfate
For research use only
⚠ WARNING: This product can expose you to chemicals including Vincristine sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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