Vincristine sulfate

Name: Vincristine sulfate
Brand: Tocris Bioscience
SKU: 1257
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1257

Citations (9)

(1)

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Key Product Details

Description:	Disrupts microtubules
Chemical Name:	22-Oxovincaleukoblastine
Purity:	≥96% (HPLC)
Molecular Weight:	923.04

View Full Technical Details for Vincristine sulfate

Biological Activity for Vincristine sulfate

Vincristine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.

Technical Data for Vincristine sulfate

M. Wt	923.04
Formula	C₄₆H₅₆N₄O₁₀.H₂SO₄
Storage	Store at -20°C
Purity	≥96% (HPLC)
CAS Number	2068-78-2
PubChem ID	249332
InChi Key	AQTQHPDCURKLKT-JKDPCDLQSA-N
Smiles	OS(O)(=O)=O.[H][C@@]23N(C=O)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Vincristine sulfate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for Vincristine sulfate

The following data is based on the product molecular weight 923.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.08 mL	5.42 mL	10.83 mL
5 mM	0.22 mL	1.08 mL	2.17 mL
10 mM	0.11 mL	0.54 mL	1.08 mL
50 mM	0.02 mL	0.11 mL	0.22 mL

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References for Vincristine sulfate

References are publications that support the biological activity of the product.

Wang The effect of antimicrotubule agents on signal transduction pathways of apoptosis. Cancer Chemother.Pharmacol. 1999 PMID: 10501907
Takano Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol.Res.Pract. 1993 PMID: 8321748
Jordan Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 1985 PMID: 3986806

Citations for Vincristine sulfate (9)

Showing 1 - 9 of 9 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Vincristine sulfate include:

Mabe et al. (2018) Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. J Clin Invest. 128:4413
PMID: 30148456
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther. 16(6):1021
PMID: 28265007
Torres et al. (2016) Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells. Oncotarget. 7:67373
PMID: 27634913
Stojcheva et al. (2016) MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM. Oncotarget. 7:12937
PMID: 26887050
Goldman et al. (2015) Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition. Nat Commun. 6:6139
PMID: 25669750
Kathawala et al. (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget. 6:510
PMID: 25402202
Knutson et al. (2014) Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One. 9:e111840
PMID: 25493630
Kathawala et al. (2014) Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study. Mol Cancer Ther. 13:714
PMID: 24431074
Heinemann et al. (2011) Synergistic effects of oncolytic reovirus and doce. chemotherapy in prostate cancer. Sci Rep. 11:221
PMID: 21645351

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Customer Reviews for Vincristine sulfate (1)

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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: Human epidermal carcinoma cell line

Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.

PMID: 28265007

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Product Documents for Vincristine sulfate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Vincristine sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov