RAGE antagonist peptide

Name: RAGE antagonist peptide
Brand: Tocris Bioscience
SKU: 6259
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 6259

Citations (2)

(1)

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Key Product Details

Description:	RAGE antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1272.56

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Biological Activity for RAGE antagonist peptide

RAGE antagonist peptide is a receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and RAGE-mediated NF-κB activity in human PDAC cell lines. Inhibits effects of TDI exposure in BALB/c mice.

Technical Data for RAGE antagonist peptide

M. Wt	1272.56
Formula	C₅₇H₁₀₁N₁₃O₁₇S
Single Letter Sequence	ELKVLMEKEL (Modifications: Glu-1 = N-terminal Ac, Leu-10 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1092460-91-7
PubChem ID	127021052
InChi Key	UPCWJIBXKJZZLN-YZLORNOTNA-N
Smiles	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RAGE antagonist peptide

Solubility

Soluble to 1mg/ml in water

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References for RAGE antagonist peptide

References are publications that support the biological activity of the product.

Yao The receptor for advanced glycation end products is required for beta -catenin stabilization in a chemical-induced asthma model. Br.J.Pharmacol. 2016 PMID: 27332707
Arumugam S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin.Cancer.Res. 2012 PMID: 22718861

Citations for RAGE antagonist peptide (2)

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Citations are publications that use Bio-Techne products. Selected citations for RAGE antagonist peptide include:

Thom et al. (2023) Blood-Borne Microparticles Are an Inflammatory Stimulus in Type 2 Diabetes Mellitus Immunohorizons. 7:71
PMID: 36645851
Uderhardt et al. (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 177:541
PMID: 30955887

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Customer Reviews for RAGE antagonist peptide (1)

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Good inhibitor

Name: Stefan Uderhardt

Species: Mouse

Assay Type: In Vivo

Cell Line/Tissue: phagocyte

H20 dilution 10 μM

PMID: PMID: 30955887

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Product Documents for RAGE antagonist peptide

COA

Certificate of Analysis

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