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29 results for "DNA, RNA and Protein Synthesis Compounds" in Products

DNA, RNA and Protein Synthesis Compounds Products

RNA, DNA and protein synthesis are fundamental processes necessary for all life.

RNA synthesis (transcription) begins by uncoiling a section of DNA that will be used as the template. RNA polymerase binds to a promoter sequence and initiates separation of the DNA double helix. Complementary ribonucleotides align and RNA polymerase catalyzes their polymerization. The newly synthesized RNA strand undergoes post-transcriptional processing before it leaves the nucleus.

Protein synthesis ...

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Non-selective protein kinase inhibitor

Alternate Names: AM-2282
Chemical Name: [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Purity: ≥98% (HPLC)
(2)

Selective orthosteric inhibitor of the BRCA2-RAD51 interaction

Chemical Name: N-(2-((2S,4R)-2-(((S)-1-(2-Chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-hydroxypyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide
Purity: ≥98% (HPLC)
Selective orthosteric inhibitor of the BRCA2-RAD51 interaction

RNA conformation probe; reagent for COMRADES RNA platform

Alternate Names: psoralen-triethylene glycol azide
Chemical Name: 3-(13-Azido-5,8,11-trioxa-2-azatridec-1-yl)-2,5,9-trimethyl-7H-furo[3,2-g][1]benzopyran-7-one
Purity: ≥98% (HPLC)
RNA conformation probe; reagent for COMRADES RNA platform

Thymidine analog for labeling DNA; can be linked to a fluorophore by click chemistry

Chemical Name: 5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Purity: ≥95% (HPLC)
Thymidine analog for labeling DNA; can be linked to a fluorophore by click chemistry

Reagent for RNA SHAPE-MaP experiments in vivo; cell permeable

Chemical Name: (2-Aminopyridin-3-yl)(1H-imidazol-1-yl)methanone
Reagent for RNA SHAPE-MaP experiments in vivo; cell permeable

Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation

Alternate Names: CP 62993
Chemical Name: 13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
Purity: ≥98% (HPLC)
Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation

Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response

Chemical Name: 1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Purity: ≥98% (HPLC)
Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response

Selective SMN2 gene splicing modifier

Chemical Name: 7-(4,7-Diazaspiro[2.5]oct-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
Purity: ≥98% (HPLC)
Selective SMN2 gene splicing modifier

Alkylating agent; chemotherapeutic

Chemical Name: 2-[bis(2-Chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
Purity: ≥98% (HPLC)
Alkylating agent; chemotherapeutic

Uridine analog, used for labeling RNA synthesis

Chemical Name: 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpyrimidine-2,4(1H,3H)-dione
Purity: ≥98% (HPLC)
Uridine analog, used for labeling RNA synthesis

Molecular glue; pre-mRNA splicing modulator

Chemical Name: N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
Purity: ≥98% (HPLC)
Molecular glue; pre-mRNA splicing modulator

Potent HTT pre-RNA splicing modulator

Chemical Name: 5-[(3R)-3-(Cyclopropylamino)-1-pyrrolidinyl]-N-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-pyrazinecarboxamide
Purity: ≥98% (HPLC)
Potent HTT pre-RNA splicing modulator.

Photoreactive uridine analog for RNA sequencing

Chemical Name: 4-Thiouridine
Purity: ≥98% (HPLC)
Photoreactive uridine analog for RNA sequencing

Reagent for RNA SHAPE-MaP chemistry

Alternate Names: 1-Methyl-7-nitroisatoic anhydride
Chemical Name: 1-Methyl-7-nitro-2H-3,1-benzoxazine-2,4(1H)-dione
Purity: ≥95% (HPLC)
Reagent for RNA SHAPE-MaP chemistry

Chemoproteomic reagent, clickable electrophilic purine for RNA binding profiling in live cells

Chemical Name: 2,6-Dichloro-7-(2-propyn-1-yl)-7H-purine
Purity: ≥98% (HPLC)
Chemoproteomic reagent, clickable electrophilic purine for RNA binding profiling in live cells

IKBKAP pre-mRNA splicing modulator

Chemical Name: 2-Chloro-N-(2-furanylmethyl)-7H-purin-6-amine
Purity: ≥98% (HPLC)
IKBKAP pre-mRNA splicing modulator

Reagent for modifying RNA at 2'-OH position, for SHAPE-MAP experiments

Chemical Name: 3-((1H-1,2,4-Triazol-1-yl)sulfonyl)pyridine
Purity: ≥95% (HPLC)
Reagent for modifying RNA at 2'-OH position, for SHAPE-MAP experiments

Hypoxia-activated DNA alkylating agent prodrug

Chemical Name: (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate
Applications: AdAct
Purity: ≥98% (HPLC)
Hypoxia-activated DNA alkylating agent prodrug

HIV RNA splicing modulator

Chemical Name: 8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
Purity: ≥98% (HPLC)
HIV RNA splicing modulator

Synthetic thymidine analog; used for cell proliferation assays

Chemical Name: 5-Bromo-2-deoxyuridine
Purity: ≥98% (HPLC)
Synthetic thymidine analog; used for cell proliferation assays

eIF4A inhibitor

Chemical Name: 2-(5-(4-Butylphenyl)furan-2-yl)-6-nitroquinoline-4-carboxylic acid
Applications: CellVia
Purity: ≥98% (HPLC)
eIF4A inhibitor

Potent and selective herpes simplex virus (HSV) helicase primase inhibitor

Chemical Name: N-[5-(Aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)benzeneacetamide
Purity: ≥98% (HPLC)
Potent and selective herpes simplex virus (HSV) helicase primase inhibitor

Metabolite generated by cytosol nonspecific dipeptidase (CNDP2) during intense exercise

Chemical Name: N-[(2S)-2-Hydroxy-1-oxopropyl]-L-phenylalanine
Purity: ≥95% (HPLC)
Metabolite generated by cytosol nonspecific dipeptidase (CNDP2) during intense exercise

TERT activator

Chemical Name: N-(3-Chloro-4-fluorophenyl)-4-fluoro-3,5-dimethylbenzenesulfonamide
Purity: ≥98% (HPLC)
TERT activator

Binds to SARS-CoV-2 frameshifting element and reduces frameshifting efficiency

Chemical Name: 3-[[4-(Methylamino)-2-quinazolinyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Binds to SARS-CoV-2 frameshifting element and reduces frameshifting efficiency
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