LNT 1
Tocris Bioscience, part of Bio-Techne | Catalog # 6510
Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
Key Product Details
Description
Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
Product Description
LNT 1 is a potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.Product Specifications
Molecular Weight
332.33
Formula
C15H12N2O5S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS Number
824983-91-7
PubChem ID
11652865
InChI Key
MXQGCMQXTPTJJT-UHFFFAOYSA-N
SMILES
ON1C(N(C2=C(C1=O)SC=C2)CC3COC4=CC=CC=C4O3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.62 | 50 |
Preparing Stock Solutions
for LNT 1
The following data is based on the product molecular weight 332.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.02 mL | 30.09 mL | 60.18 mL |
| 2.5 mM | 1.20 mL | 6.02 mL | 12.04 mL |
| 5 mM | 0.60 mL | 3.01 mL | 6.02 mL |
| 25 mM | 0.12 mL | 0.60 mL | 1.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ward Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One 2017 PMID: 28628639
- Exell Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat.Chem.Bio. 2016 PMID: 27526030
Product Specific Notices for LNT 1
For research use only
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