DNA, RNA and Protein Synthesis Compounds

Non-selective protein kinase inhibitor

Synthetic thymidine analog; used for cell proliferation assays

Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response

Reagent for RNA SHAPE-MaP chemistry

Molecular glue; pre-mRNA splicing modulator

Photoreactive uridine analog for RNA sequencing

Selective orthosteric inhibitor of the BRCA2-RAD51 interaction

Hypoxia-activated DNA alkylating agent prodrug

Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation

Alkylating agent; chemotherapeutic

Potent and selective DYRK1A inhibitor

HIV RNA splicing modulator

RNA conformation probe; reagent for COMRADES RNA platform

Modulator of alternative polyadenylation; inhibits rod photoreceptor gene expression via Nr2e3

Uridine analog, used for labeling RNA synthesis

Thymidine analog for labeling DNA; can be linked to a fluorophore by click chemistry

Potent and selective herpes simplex virus (HSV) helicase primase inhibitor

Binds to SARS-CoV-2 frameshifting element and reduces frameshifting efficiency

IKBKAP pre-mRNA splicing modulator

eIF4A inhibitor

Auxin antagonist of TIR1/AFB receptors; also OsTIR1 inhibitor in auxin-inducible degron (AID) system

Selective SMN2 gene splicing modifier

Metabolite generated by cytosol nonspecific dipeptidase (CNDP2) during intense exercise

Reagent for modifying RNA at 2'-OH position, for SHAPE-MAP experiments

Potent HTT pre-RNA splicing modulator