Covidcil-19

Name: Covidcil-19
Brand: Tocris Bioscience
SKU: 7485

Tocris Bioscience, part of Bio-Techne | Catalog # 7485

COA / SDS

Binds to SARS-CoV-2 frameshifting element and reduces frameshifting efficiency

Key Product Details

Description:	Binds to SARS-CoV-2 frameshifting element and reduces frameshifting efficiency
Chemical Name:	3-[[4-(Methylamino)-2-quinazolinyl]amino]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	294.31

View Full Technical Details for Covidcil-19

Technical Data
Citations

Biological Activity for Covidcil-19

Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (K_d = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.

Technical Data for Covidcil-19

M. Wt	294.31
Formula	C₁₆H₁₄N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1225177-95-6
PubChem ID	52108194
InChi Key	ATKIOCNKZKNVQS-UHFFFAOYSA-N
Smiles	CNC1=NC(NC2=CC(C(O)=O)=CC=C2)=NC3=C1C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Covidcil-19

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.94	10

Preparing Stock Solutions for Covidcil-19

The following data is based on the product molecular weight 294.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.98 mL	169.89 mL	339.78 mL
0.5 mM	6.80 mL	33.98 mL	67.96 mL
1 mM	3.40 mL	16.99 mL	33.98 mL
5 mM	0.68 mL	3.40 mL	6.80 mL

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Reconstitution Calculator

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References for Covidcil-19

References are publications that support the biological activity of the product.

Giorgio New chemical modalities enabling specific RNA targeting and degradation: application to SARS-CoV-2 RNA. ACS Cent.Sci. 2020 PMID: 33140031
Haniff Targeting the SARS-CoV-2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders. ACS Cent.Sci. 2020 PMID: 33140033