CHDI 113
Tocris Bioscience, part of Bio-Techne | Catalog # 8063
Potent HTT pre-RNA splicing modulator
Key Product Details
Description
Potent HTT pre-RNA splicing modulator
Product Description
CHDI 113 is a potent huntingtin (HTT) pre-mRNA splicing modulator (EC50 = 66 nM). It lowers HTT protein in both human Huntington's disease (HD) stem cells and in the brain of BACHD (bacterial artificial chromosome-mediated transgenic) mouse model. CHDI 113 is brain penetrant and orally bioavailable.Licensing Information
Sold under license from CHDI FoundationProduct Specifications
Molecular Weight
395.44
Formula
C20H22FN7O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-[(3R)-3-(Cyclopropylamino)-1-pyrrolidinyl]-N-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-pyrazinecarboxamide
CAS Number
2743336-70-9
PubChem ID
166508076
InChI Key
VPWHAEPYJSEFEH-CQSZACIVSA-N
SMILES
FC1=CC(NC(C2=NC=C(N3C[C@@H](CC3)NC4CC4)N=C2)=O)=CN5C1=NC(C)=C5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.54 | 100 |
Preparing Stock Solutions
for CHDI 113
The following data is based on the product molecular weight 395.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.64 mL | 25.29 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Liu Identification and optimization of RNA-splicing modulators as Huntingtin protein-lowering agents for the treatment of Huntington's disease. J.Med.Chem. 2023 PMID: 37712656
Product Specific Notices for CHDI 113
For research use only
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