Lac-Phe

Name: Lac-Phe
Brand: Tocris Bioscience
SKU: 7942

Tocris Bioscience, part of Bio-Techne | Catalog # 7942

COA / SDS

Metabolite generated by cytosol nonspecific dipeptidase (CNDP2) during intense exercise

Key Product Details

Description:	Metabolite generated by cytosol nonspecific dipeptidase (CNDP2) during intense exercise
Chemical Name:	N-[(2S)-2-Hydroxy-1-oxopropyl]-L-phenylalanine
Purity:	≥95% (HPLC)
Molecular Weight:	237.26

View Full Technical Details for Lac-Phe

Technical Data
Citations

Biological Activity for Lac-Phe

Lac-Phe is a metabolite generated from lactate and phenylalanine by cytosolic non-specific dipeptidase (CNDP2) during intense exercise. Lac-Phe reduces food intake in diet-induced obese mice without affecting movement or energy expenditure. When administrated chronically, Lac-Phe decreases adiposity and body weight and improves glucose homeostasis.

Technical Data for Lac-Phe

M. Wt	237.26
Formula	C₁₂H₁₅NO₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	183241-73-8
PubChem ID	11075454
InChi Key	IIRJJZHHNGABMQ-WPRPVWTQSA-N
Smiles	C[C@H](O)C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lac-Phe

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.73	100

Preparing Stock Solutions for Lac-Phe

The following data is based on the product molecular weight 237.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.21 mL	21.07 mL	42.15 mL
5 mM	0.84 mL	4.21 mL	8.43 mL
10 mM	0.42 mL	2.11 mL	4.21 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

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References for Lac-Phe

References are publications that support the biological activity of the product.

Li An exercise-inducible metabolite that suppresses feeding and obesity. Nature 2022 PMID: 35705806