CEP

Name: CEP
Brand: Tocris Bioscience
SKU: 8108

Tocris Bioscience, part of Bio-Techne | Catalog # 8108

COA / SDS

Chemoproteomic reagent, clickable electrophilic purine for RNA binding profiling in live cells

Key Product Details

Description:	Chemoproteomic reagent, clickable electrophilic purine for RNA binding profiling in live cells
Chemical Name:	2,6-Dichloro-7-(2-propyn-1-yl)-7H-purine
Purity:	≥98% (HPLC)
Molecular Weight:	227.05

View Full Technical Details for CEP

Technical Data
Citations

Biological Activity for CEP

CEP is a chemoproteomic reagent. It is a clickable electrophilic purine used to directly quantify protein-RNA interactions on proteins through photoaffinity competition with 4-thiouridine (4SU)-labeled RNA in cells. It is a cysteine reactive probe used in photo-activatable-competition and chemoproteomic enrichment (PACCE) method for global quantification of protein-RNA interactions in living cells.

Technical Data for CEP

M. Wt	227.05
Formula	C₈H₄Cl₂N₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1838570-66-3
PubChem ID	155590179
InChi Key	DQZMJDUCMIRFBJ-UHFFFAOYSA-N
Smiles	ClC1=NC(N=CN2CC#C)=C2C(Cl)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CEP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	22.7	100
	ethanol	2.27	10 with gentle warming

Preparing Stock Solutions for CEP

The following data is based on the product molecular weight 227.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.40 mL	22.02 mL	44.04 mL
5 mM	0.88 mL	4.40 mL	8.81 mL
10 mM	0.44 mL	2.20 mL	4.40 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

Molarity Calculator

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Reconstitution Calculator

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References for CEP

References are publications that support the biological activity of the product.

Heindel Chemoproteomic capture of RNA binding activity in living cells. Nat.Commun. 2023 PMID: 37805600

CEP