TAC
Tocris Bioscience, part of Bio-Techne | Catalog # 8825
TERT activator
Product Description
TAC is a telomerase reverse transcriptase (TERT) activator. TAC upregulates TERT gene transcription via the MEK/ERK/AP-1 cascade. In primary human cells and naturally aged mice, TAC enhances telomere synthesis, reduces tissue aging markers, cellular senescence, and inflammatory cytokines. In the brain, TAC induces neurogenesis, reduces neuroinflammation, and preserves cognitive function.Product Specifications
Molecular Weight
331.76
Formula
C14H12ClF2NO2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(3-Chloro-4-fluorophenyl)-4-fluoro-3,5-dimethylbenzenesulfonamide
CAS Number
666699-46-3
PubChem ID
2805068
InChI Key
JVUSVLUQMXGABO-UHFFFAOYSA-N
SMILES
O=S(NC1=CC=C(C(Cl)=C1)F)(C2=CC(C)=C(F)C(C)=C2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.18 | 100 | |
| Ethanol | 33.18 | 100 |
Preparing Stock Solutions
for TAC
The following data is based on the product molecular weight 331.76
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.07 mL | 30.14 mL |
| 5 mM | 0.60 mL | 3.01 mL | 6.03 mL |
| 10 mM | 0.30 mL | 1.51 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shim TERT activation targets DNA methylation and multiple aging hallmarks. Cell 2024 PMID: 38908367
Product Specific Notices for TAC
For research use only
Loading...
Loading...